Each 15-minute podcast will provide an overview of the issue's contents and relevant news in the field of basic/translational cardiovascular biology followed by an in-depth discussion of a featured article. This discussion will pull opinions from the podcast hosts, editorial team, research leaders and authors – both the corresponding authors as well as the trainee(s). We will provide lively discussions that give the listener a behind the scenes look at how science gets done and the implications of these fascinating discoveries.
This month on Episode 86 of Discover CircRes , host Cindy St. Hilaire highlights articles featured in the July 6 and July 17th issues of Circulation Research . This Episode also features a discussion with BCVS Outstanding Early Career Investigator Award Finalists, Drs Noor Momin, Shibali Das, and Ivan Menendez-Montes. Article highlights: Kotla, et al. LATS1/2-CD38-SUOX Axis Drives Intraplaque Thrombosis Lin, et al. ATAD3A Gates Mito-Lysosome Contacts in AAD Wang, et al. Monocyte Dll4 Induces Systemic Inflammation Chattopadhyay , et al . S100A8/A9 Aggravate Atherosclerosis
This month on Episode 85 of Discover CircRes , host Cindy St. Hilaire highlights articles featured in the May 22 nd , June 5 th and June 19th issues of Circulation Research . This Episode also features a discussion with Professor Katrin Schäfer, Dr Rajinikanth Gogiraju, and Dr Beichen Sun, about their study, Chronic Erythrocyte NO Production Accelerates Atherosclerosis by Increasing SMC De Novo Lipogenesis. Article highlights: Larcher, et al. Cardiac Fibroblast Heterogeneity and Disease Huang, et al. Vascular Endothelial NOX1 Drives Obesity Atici, et al. Role of Sirtuin-1 in Murine Vasculitis Compendium on Lipoproteins and Cardiovascular Disease
This month on Episode 84 of Discover CircRes , host Cindy St. Hilaire highlights articles featured in the April 24th and May 8 th issue of Circulation Research . This Episode also features a discussion with Dr Mete Civelek and Dr Noah Perry about their study, Female-Biased Vascular Smooth Muscle Cell Gene Regulatory Networks Predict MYH9 as a Key Regulator of Fibrous Plaque Phenotype. Article highlights: Westhoff, et al. PTEN and PIP3 in AngII-Induced Cardiac Pathology Witmer, et al. Novel Mode of SCN5A-Mitochondrial Crosstalk Ghiringhelli, et al. Light-Controllable Humanized Bioengineered Atria Wang, et al. Exercise-Induced Cardiomyocyte EVs Deliver EPPIR
This month on Episode 83 of Discover CircRes , host Cindy St. Hilaire highlights articles featured in the March 27th and April 10th issue of Circulation Research . This Episode also features a discussion with Dr Martin Schwartz and Dr Hanqiang Deng about their study, FOXO1 Integrates Endothelial Hemodynamic, Inflammatory, and Metabolic Pathways in Atherosclerosis . Article highlights: Tadokoro, et al. CRISPR Base Editing of PKCα Rescues Heart Failure Joki, et al. PTH Affects Right Heart Hemodynamics Compendium on Migration of Mitochondria Beyond Cell Boundary
This month on Episode 82 of Discover CircRes , host Cindy St. Hilaire highlights articles featured in the February 27th and March 13th issue of Circulation Research . This Episode also features a discussion with Dr John Hall and Dr Ana Omoto from the University of Mississippi Medical Center about their study, Leptin Activates Brain-BAT-Heart Crosstalk to Promote Cardiac Protection. Article highlights: Sakkers, et al. Atherosclerotic Fibrous Plaques in Women Ruberto, et al. Mitochondrial Biogenesis and Heart Regeneration Simon-Chica, et al. Non-Myocytes Modulate Atrial Fibrillation Dynamics Zhao, et al. USP10 Inhibits cGAS-STING via MTX2
This month on Episode 81 of Discover CircRes , host Cindy St. Hilaire highlights articles featured in the January 30th and February 13th issue of Circulation Research . This Episode also features a discussion with Dr Claudia Goettsch and Nicolas Hense, about their study, 1-Phosphatidylinositol 3-Phosphate 5-Kinase Inhibition by Apilimod Promotes an Adipocyte-like Vascular Smooth Muscle Cell Phenotype and Prevents Arterial Calcification. Article highlights: Hu, et al. CircZBTB44 Inhibits Calcific Aortic Valve Disease Schemelei, et al. Olfr2 Aggravates AAA Formation Zhang, et al. Neratinib Protects Against Atherosclerosis Sun, et al. CD34+ Cells in Transplants
This month on Episode 80 of Discover CircRes , host Cindy St. Hilaire highlights articles featured in the January 2 nd and January 16 th issue of Circulation Research . This Episode also features a discussion with Dr Colin Evans and Dr You-Yang Zhao about their study, The Unexpected Protective Role of Thrombosis in Lung Injury via Endothelial ALOX15. Article highlights: Viskadourou, et al. Endothelial REST in Atherosclerosis Torre, et al. Silencing the Chronotropic Heart Rate Response Chen, et al. Histone Lactylation and Cardiac Hypertrophy Vázquez-Reyes, et al. Diurnal Neutrophil Function Drives Stroke Outcome
This month on Episode 79 of Discover CircRes , host Cindy St. Hilaire highlights articles featured in the December 5th issue of Circulation Research . This Episode also features a discussion with Dr Nobuaki Fukuma and Dr Emily Tsai from Columbia University Vagelos College of Physicians and Surgeons about their study, Cardiomyocyte GC1 Mediates Estrogenic Angiogenesis in Right Heart Remodeling. Article highlights: Hamilton, et al. RyR2 Hyperactivity Remodels Mitochondria Singhal, et al. TRIB3 Activation Impairs Efferocytosis Tsai, et al. YAP Induces Glycolysis to Drive Fibroinflammation
This month on Episode 78 of Discover CircRes , host Cindy St. Hilaire highlights articles featured in the October 24 th and November 7 th issues of Circulation Research . This Episode also features a discussion with Thomas Hund and Drew Nassal from the Ohio State University about their study, The βIV-Spectrin/STAT3 Complex Regulates the Orientation of Cardiac Hypertrophic Growth . Article highlights: Dhawan, et al. Macrophage DNases Clear Tissue NETs Pakkiriswami, et al. LV and RV Responses to Elevated Mitochondrial Ca 2+ Liu, et al. CCL21 Enhances Platelet Activation Morales, et al. Vascular Niches and Cardiac Aging
This month on Episode 76 of Discover CircRes , host Cindy St. Hilaire highlights articles featured in the August 29th and September 12th issues of Circulation Research . This Episode also features a discussion with Drs Swapnil Sonkusare and Mani Kuppusamy about their manuscript, Paracrine Smooth Muscle-to-Endothelial Signaling via TNF Elevates Blood Pressure in Obesity . Article highlights: Tombor, et al. Immunomodulatory Endothelial Cells After Heart Attack Du, et al. CAR-Ms Engineered In Vivo for Attenuating MIRI Pauza, et al. MC4R Activates Carotid Body in Hypertension Cai, et al. Lkb1 KO in PVAT Drives Aortic Aneurysm Formation
This month on Episode 75 of Discover CircRes , host Cindy St. Hilaire highlights articles featured in the August 1 st and August 15th issues of Circulation Research . This Episode also features a discussion with Abigail Ajanel, Dr Robbie Campbell and Dr Frederik Denorme about their study, Mitochondrial Calcium Uniporter Regulates ITAM-Dependent Platelet Activation. Article highlights: Lan, et al. TRIM16 Exacerbates Vascular Calcification Zhang, et al. HADHA Lactylation in Septic Myocardial Depression Li, et al. AR Links to CVMs Baudel, et al. Vascular Panx1 in Diabetic Hyperglycemia
This month on Episode 74 of Discover CircRes , host Cindy St. Hilaire highlights articles featured in the June 20 th and July 4 th issues of Circulation Research . This Episode also features a discussion with the finalists for the 2025 BCVS Outstanding Early Career Investigator Award. Article highlights: Kimura, et al. Novel Genetic Mouse Model of Aortic Dissection Getaneh, et al. Aspirin Non-Responsiveness in Preeclampsia Introduction to the Compendium on Cardiopulmonary Disease and Exercise: Molecular to Clinical Mechanisms
This month on Episode 73 of Discover CircRes , host Cindy St. Hilaire highlights articles featured in the May 23rd and June 6th issues of Circulation Research . This Episode also includes a discussion with Dr Jae Min Cho and Tzung Hsiai, about their study, Habitual Exercise Modulates Neuroimmune Interaction to Mitigate Aortic Stiffness. Article highlights: Interorgan Crosstalk in Heart Failure and Cardiometabolic Diseases: A Compendium He, et al. NEP in Placental EVs Triggers Hypertension in PE Dennis, et al. FoxO1-zDHHC4-CD36 S-Acylation Axis in Diabetes
This month on Episode 72 of Discover CircRes , host Cindy St. Hilaire highlights four articles featured in the April 25th and May 9th issues of Circulation Research . This Episode also includes a discussion with Dr Sarah Costantino and Dr Francesco Paneni from University Hospital Zurich about their study, Chromatin Rewiring by SETD2 Drives Lipotoxic Injury in Cardiometabolic HFpEF Article highlights: Laudette, et al. PCSK9 and Mitochondrial Cholesterol in Heart Yang, et al. Srsf3 Limits AS by Lengthening 3′ UTRs of mtARSs Li, et al. CircCDYL Contributes to Cardiac Hypertrophy Zhakeer, et al. T reg Cells Regulate Pulmonary Venous Remodeling
This month on Episode 71 of Discover CircRes , host Cindy St. Hilaire highlights three articles featured in the March 28 th and April 11 th issues of Circulation Research . This Episode also includes a discussion with Dr Magali Noval Rivas and Dr Prasant Jena from Cedars-Sinai Medical Center about their study, Intestinal Microbiota Contributes to the Development of Cardiovascular Inflammation and Vascular in Mice. Article highlights: Han, et al. PRL2 Dephosphorylates AMPKα2 in Heart Perelli, et al. TAX1BP3 and Arrhythmogenic Cardiomyopathy Lalaguna, et al. Overexpression of Wild Type TMEM43 Improves ARVC5 Liu, et al. NR4A1 Inhibits Platelet Function
This month on Episode 70 of Discover CircRes , host Cindy St. Hilaire highlights three articles featured in the February 28th issue of Circulation Research and the Compendium on Lifelong Care in Women: Applying a Sex- and Gender-Lens to Practice in the March 14 th issue. This Episode also includes a discussion with Dr Matt Rossman and Sanna Darvish from the University of Colorado, Boulder about their study, Preservation of Vascular Endothelial Function in Late Onset Postmenopausal Women . Article highlights: Huang, et al. Targeting CXCR3 in ICI-Mediated Myocarditis Ju, et al. RIC-Enhanced Efferocytosis on Stroke Recovery Halmos, et al. Cholesterol Efflux Pathways Control SMC Function Compendium on Lifelong Care in Women: Applying a Sex- and Gender-Lens to Practice
This month on Episode 69 of Discover CircRes , host Cindy St. Hilaire highlights four articles featured in the January 31st and February 14th issues of Circulation Research . This Episode also includes a discussion with Dr Frank Conlon and graduate student Ike Emerson about their study, X Chromosome-Linked MicroRNAs Regulate Sex Differences in Cardiac Physiology. Article highlights: Huang, et al. Vps4a Safeguards Plasma Membrane Integrity Liu, et al. PPM1B Deubiquitination Promotes Arterial Stiffness Muralitharan, et al. GPR41/43 and Blood Pressure Park, et al. Ferroptosis and Its Consequences in Preeclampsia
This month on Episode 68 of Discover CircRes , host Cindy St. Hilaire highlights four articles featured in the January 3 rd and January 17th issues of Circulation Research . This Episode also includes a discussion with Drs Gianluigi Condorelli and Marinos Kallikourdis about their study Autoimmune-like Mechanism in Heart Failure Enables Preventative Vaccine Therapy. Article highlights: Yoshida, et al. FAP Vaccine Improves Cardiac Fibrosis Johansen, et al. TCF21 and Cardiac Fibrosis Pabon, et al. Endothelial METAP1 in Preeclampsia Mutchler, et al. ET-3/ETBR, Immune Cells, and Kidney Lymphatics
This month on Episode 67 of Discover CircRes , host Cindy St. Hilaire highlights articles featured in the December 6th issues of Circulation Research . This Episode also includes a discussion with Drs Jesse Rowley and Shancy Jacob about their study, Mitofusin-2 Regulates Platelet Mitochondria and Function . Article highlights: Bardhan, et al. Sex Specific Roles of Microbiota in Hypertension Ma, et al. Kindlin-2 LLPS Controls Vascular Stability Wang, et al. CAR-Ms Alleviate Myocardial I/R Injury
