Nick Norwitz MD PhD - Metabolic Health & Longevity

In this conversation with Mike Mutzel, MS from the High Intensity Health channel, we dive into some of the most interesting 2025 heart health studies. We explored the gut-heart axis, how body fat can alter blood vessel function and touch on oxidative stress, inflammation, the microbiome, protein, hormones and how they all relate to heart health. If you are interested in cardiovascular health nutrition, and metabolism, this one is for you!Chapter*Call our service line at 815-STAY-CUR (815-782-9287) or visit https://askchapter.org/staycurious*Learn more about the data, here: https://staycuriousmetabolism.substack.com/p/life-or-death-in-the-fine-print-the?r=40ekz2 Mike’s YouTube Channel: https://www.youtube.com/user/highintensityhealth For Deeper Dive’s into the Content Discussed:*Referenced Videos:Paper 1: Imidazole Propionate and Heart Health https://youtu.be/P7CZvAnB53E Autophagy and Depression https://youtu.be/MCCb5VkckU0 Paper 2: Aging, Phenylacetic Acid and Heart Health https://youtu.be/H0OaXcIobgM Young Blood and Longevity https://youtu.be/lTMjmHKc2Ys Paper 3: Myeloperoxidase, Obesity and Heart Health https://youtu.be/inTK-9DCxf0 *Other Referenced Content:Homovanillic Acid, Microbiome and Depression https://staycuriousmetabolism.substack.com/p/the-microbiomemood-link-a-three-ingredient?r=40ekz2 Dogs and health https://staycuriousmetabolism.substack.com/p/the-science-of-dogs-and-better-health?r=40ekz2 Leptin, Salt and Blood Pressure https://staycuriousmetabolism.substack.com/p/salt-vs-fat-rethinking-the-root-causes?r=40ekz2 Four Types of Diabetes (The Cliffhanger!): https://staycuriousmetabolism.substack.com/p/types-four-of-diabetes-what-new-technologies?r=40ekz2 Chapters:00:00 – Dipping into 2025 Heart Health Studies2:25 – The Shift in Heart Health Focus Beyond ApoB and LDL8:03 – Imidazole Propionate and Heart Health – And Internet Confusion22:15 – Chapter: Healthcare and Longevity 24:02 – Gut Health, Heart Health, Aging and Phenylacetic Acid 26:50 – Mechanisms to Improve Gut Metabolism and Lower Phenylacetic Acid37:45 – How Fat Tissue and Myeloperoxidase Impact Vascular Health43:23 – Final Reflections: A Systems View of Metabolic Health*Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan’s contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don’t directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your options.#metabolichealth #mikemutzel #nicknorwitz #2025healthstudies #inflammation #phenylaceticacid #apob #hearthealth #lipidstudies #guthealth #sleepandmetabolism #insulinresistance #myeloperoxidase #autophagy #longevityscience #nutritionalbiochemistry #healthoptimization #functionalmedicine #healthscience #chronicinflammation #cardiovascularrisk #biomarkers #longevityresearch #metabolicmarkers #functionalmedicine #healthscience #chronicinflammation #cardiovascularrisk #biomarkers #longevityresearch #metabolicmarkers #staycurious Learn more about your ad choices. Visit megaphone.fm/adchoices

For more nuances and references, see the associated Newsletter: https://staycuriousmetabolism.substack.com/p/can-we-trap-a-microbial-toxin-to?r=40ekz2 Winnow Microplastic Binding Probiotic, Affiliate Link (15% off): https://www.winnowlabs.com/STAYCURIOUSMicroplastics and Cardiovascular Disease, Letter: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2 A new study has uncovered a surprising metabolic villain — D-lactate, the molecular twin of the lactate that fuels your muscles. Unlike L-lactate, D-lactate builds up in people with obesity and contributes to insulin resistance, fatty liver, and metabolic dysfunction. But scientists have now found a way to trap this molecule in the gut, potentially opening the door to a brand-new class of metabolic therapies. In this video, Nick Norwitz MD PhD explains the study, its implications for human health, and how certain probiotics and homemade yogurts could help reduce D-lactate levels naturally.Chapters:0:00 – The Evil Twin of Lactate: New Research Explained1:18 – L-Lactate vs D-Lactate: Why the Difference Matters2:43 – Elevated D-Lactate in Obesity: The Hidden Connection3:18 – How D-Lactate Worsens Blood Sugar and Metabolic Health4:00 – Gut Microbes: The Source of D-Lactate6:30 – The D-Lactate Trap: How Scientists Made Mice Poop It Out9:11 – What This Discovery Means for Metabolic Research9:42 – Practical Takeaways: What You Can Do Right Now#Lactate # microbiome #metabolichealth #fatloss #insulinsensitivity #diabetes #obesity #weightloss #educationa #staycurious #inflammation #yogurt #guthealth #biochemistry #metabolism #glucosecontrol #bloodsugar #fattyliver #insulinresistance #healthscience #nutritionresearch #probiotics #gutmicrobiome #scienceexplained #wellnessscience #hormones #metabolicsyndrome Learn more about your ad choices. Visit megaphone.fm/adchoices

Link: https://pubmed.ncbi.nlm.nih.gov/29317623/Newer Video (April 2024): https://youtu.be/pr93EsEV2bM?si=AEcnv1jlUoEWF-e1 Learn more about your ad choices. Visit megaphone.fm/adchoices

For references and a written breakdown, see the associated newsletter: https://staycuriousmetabolism.substack.com/p/weve-been-prescribing-statins-wrong?r=40ekz2 For a consolidated resource on prior StayCurious Heart Health Content, check out our Heart Health Map! https://open.substack.com/pub/staycuriousmetabolism/p/the-intricate-metabolic-web-of-heart?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=trueStatins are among the most prescribed and profitable drugs in the world, but new research is forcing us to rethink what they actually do — and for whom. In this video, Dr. Nick Norwitz MD PhD breaks down the latest data showing that statins only reduce cardiovascular risk in people with existing heart disease, while showing little or no benefit for those without.Nick walks through, not one, but 4 major studies and explains why LDL cholesterol and ApoB aren’t the whole story, how coronary imaging (CAC or CTA scans) provide better risk prediction, and why the real root causes — like insulin resistance and mitochondrial dysfunction — often get ignored. This isn’t about conspiracy or fear — it’s about context. Good medicine isn’t black or white — it’s nuanced, transparent, and collaborative.Chapters0:00 – Intro: Statins as a Misunderstood Tool1:46 – Paper 1, Statins Don’t Benefit Those Without Heart Disease3:43 – Imaging Beats LDL and ApoB for Risk Stratification4:26 – Paper 2, If Your Heart is Clear, Does LDL Cholesterol Matter?5:33 – Reviewing the Pros and Cons of Statins6:43 – Paper 3, Statins Harm Mitochondria and Muscles7:55 – Paper 4, Statins Slash GLP-1 Levels9:00 – The Essential Social Dynamics of Statins You Need to Know11:15 – Conclusion, The Right Tool for the Right Job#Statins #HeartHealth #Cholesterol #LDL #ApoB #InsulinResistance #MetabolicHealth #Mitochondria #Type2Diabetes #CardiovascularHealth #Medicine #Pharmaceuticals #GLP1 #CoQ10 #StayCurious #NickNorwitz #Educational #ScienceCommunication #CriticalThinking #HealthResearch #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices

Shawn Baker Tweet: https://x.com/SBakerMD/status/1728878646793003085?s=20Nick Tweet: https://x.com/nicknorwitz/status/1729122883564171274?s=200:12: Data “leak”0:50: Who am I? (For those who don’t know me)1:54: Lean Mass Hyper-Responders2:56: What (design and hypothesis)5:15: Why am I doing this?7:13 – 9:40: “How” (Lipid Energy Model)Other details and Final commentsLipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/LMHR, first paper: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext JCL LMHR editorial: https://www.lipidjournal.com/article/S1933-2874(22)00295-1/fulltextLMHR, low saturated fat case report: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048595/ Learn more about your ad choices. Visit megaphone.fm/adchoices

Microplastics and Cardiovascular Disease Letter: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2 Winnow Affiliate Link (15% off): https://www.winnowlabs.com/STAYCURIOUSWinnow is a first-in-class probiotic that binds microplastics to provide a microplastic shield from your inside. See the letter above for more details.Inulin StayCurious Newsletter: https://staycuriousmetabolism.substack.com/p/the-fiber-that-fights-fat-how-inulin?r=40ekz2 Inulin Video: https://youtu.be/blNLHsww_Qs Andrew Koutnik, Interview 1: https://youtu.be/2doAS18X9kA Andrew Koutnik, Interview 2: https://youtu.be/-vdol1TSxoc Andrew Koutnik, Interview 3: https://youtu.be/NrZlvtWIgBAIn this episode, Dr Andrew Koutnik and I dive deep into the science of fiber, keto, and more – focusing on two influential 2025 papers. First, we unpack the a new study revealing how a specific type of fiber can “immunize” the body against fructose by reshaping the microbiome, protecting the liver, reducing de novo lipogenesis, and boosting glutathione production. This isn’t “more fiber is better”—it’s precision nutrition.Then we break down the keto mouse study that was widely discuss for claiming ketogenic diets cause fatty liver and glucose intolerance. We explain why this particular mouse model leads to misleading results, and how diet design specifics dramatically change outcomes. When viewed through these lenses, the scare headlines collapse.We also explore how to think critically about nutrition science, why animal studies can both illuminate and mislead, how individuals can apply evidence with nuance, and why personal experimentation—combined with skepticism and curiosity—leads to better metabolic outcomes. If you're trying to understand fiber, fructose, ketogenic diets, diabetes, or simply want to make better decisions about your own metabolic health, this conversation provides clarity and actionable insight.Chapters:0:00 – Intro: Welcome Back Dr Andrew Koutnik PhD1:40 – The Coolest Fiber Paper Ever!21:19 – Probiotic That Binds Plastics22:52 – Keto Mouse Myths: A Shady Study Skews the Truth30:01 – Andrew Reflects on his Diary of a CEO Appearance 43:01 – Do Credentials Teach Curiosity, or Crush Them?#NickNorwitz #AndrewKoutnik #MetabolicHealth #NutritionScience #Inulin #FiberScience #Microbiome #GutHealth #Fructose #HFCS #LiverHealth #NAFLD #Metabolism #InsulinResistance #KetogenicDiet #KetoScience #LowCarb #Type1Diabetes #PrecisionNutrition #LongevityScience #Healthspan #ScientificDebunk #DietStudies #EvidenceBasedNutrition #ScienceExplainer #StayCurious #Glutathione #Mitochondria #DeNovoLipogenesis #MicrobiomeResearch Learn more about your ad choices. Visit megaphone.fm/adchoices

JRE #2069, Spotify: https://open.spotify.com/episode/6BVcDMKLN820nNXYSPcbwvOreo experiment, Video: https://youtu.be/GHALacs44I8?si=Oec-0YqamBj5dO1XOreo experiment, Tweet: https://x.com/nicknorwitz/status/1729122883564171274?s=20Carnivore, Harvard Study: https://pubmed.ncbi.nlm.nih.gov/34934897/LMHR study: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltextLipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/ Learn more about your ad choices. Visit megaphone.fm/adchoices

For references, extra nuances and my Lp(a) protocol, see this letter: https://staycuriousmetabolism.substack.com/p/why-lpa-may-not-be-as-dangerous-as?r=40ekz2 Relevant Prior VideosLp(a) Background Video: https://youtu.be/iVwDJqJiTEY Lp(a) and Vitamin C Video: https://youtu.be/3rbJnKnhg3s MPO Video: https://youtu.be/inTK-9DCxf0 Lipoprotein(a), or Lp(a), is one of the most feared genetic risk factors for heart disease. But new 2025 data tell a far more hopeful story.In this video, I break down a large, long-term study showing that Lp(a)-related cardiovascular risk depends heavily on metabolic context, especially waist-to-hip ratio — a simple marker of visceral fat. Shockingly, in people with low waist-to-hip ratios, even high Lp(a) levels were not associated with increased heart disease risk.We walk through the data, the graphs, the mechanisms (clotting, inflammation, oxidative stress), and the practical takeaways.Genes are not destiny. Metabolic health changes the story.Chapters0:00 – I Have Lp(a)… Oh No!1:47 – New Study on Waist-to-Hip Ratio and Lp(a)2:47 – High Lp(a) But Low WHR… Low Risk!3:31 – Look At This Graph! 4:28 – And Now Look at These Graphs!5:45 – Your Waist-to-Hip Ratio Goals7:23 – Mechanisms: Why Would Waist-to-Hip Ratio Matter for Lp(a) Risk?10:11 – Teasing the Protocol… See More at StayCurious Metabolism11:00 – Summarizing Key Points#LpA #HeartHealth #CardiovascularDisease #Genetics #MetabolicHealth #VisceralFat#WaistToHipRatio #Atherosclerosis #Inflammation #OxidativeStress #PrecisionHealth#Longevity #HealthScience #PreventiveCardiology #NickNorwitz #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices

Peter and Derek: https://www.youtube.com/watch?v=sl0LrPYZoTYLipid Energy Model: https://pubmed.ncbi.nlm.nih.gov/35629964/LMHR, first paper: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltext JCL LMHR editorial: https://www.lipidjournal.com/article/S1933-2874(22)00295-1/fulltextLMHR, low saturated fat case report: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048595/ Learn more about your ad choices. Visit megaphone.fm/adchoices

For all references and even deeper nuances, check out the StayCurious Metabolism letter: https://staycuriousmetabolism.substack.com/p/can-visceral-fat-cause-depression?r=40ekz2 Chapter*Call our service line at 815-STAY-CUR (815-782-9287) *Learn more about the data, here: https://staycuriousmetabolism.substack.com/p/life-or-death-in-the-fine-print-the?r=40ekz2 Visceral Fat Randomized Controlled Trial Video: https://youtu.be/lDeegZ1wtAIDescription:Most people think of fat as extra weight—something cosmetic or something to “burn off.” But new science is showing something far more profound: visceral fat is an endocrine organ that sends biochemical messages across the entire body, including directly into the brain. And those messages can change mood, increase stress sensitivity, and even promote depression.In this video, we break down a brand-new study revealing how visceral fat releases tiny molecular packages called extracellular vesicles. Inside those vesicles is a specific microRNA—a signal that can cross the blood-brain barrier, impair neurons in the hippocampus, lower BDNF, and induce depression-like behavior in animal models. This emerging research provides a mechanistic explanation for why obesity and depression are so tightly linked, why mood disorders often worsen with metabolic disease, and why improving metabolic health may improve mental health. Finally, we explore what you can do today—how reducing visceral fat may lower miR-145-5p, improve brain resilience, and break the vicious metabolic–mood loop. Your metabolism and your mind are not separate systems. They are one.Chapters:0:00 – Visceral Fat: More Than Storage1:03 – Can Fat Cause Depression? New Biology2:26 – The Obesity–Depression Loop3:32 – Mechanism: How Visceral Fat Sends Signals to the Brain5:07 – miR-145-5p: The Molecular “Letter” Driving Depression9:19 – What You Can Do: Reducing Visceral Fat to Protect Brain Health#visceralfat #depression #metabolichealth #extracellularvesicles #microRNA #brainhealth #inflammation #mentalhealth #obesityresearch #healthscience #NickNorwitz #StayCuriousMetabolism*Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan’s contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don’t directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your options. Learn more about your ad choices. Visit megaphone.fm/adchoices

Link: https://jn.nutrition.org/article/S0022-3166(23)72806-X/fulltexthttps://authors.elsevier.com/sd/article/S0022-3166(23)72806-X Learn more about your ad choices. Visit megaphone.fm/adchoices

Dom D’Agostino Part 1 Interview: https://youtu.be/ksV9f4jSbLQ Creatine Letter: https://staycuriousmetabolism.substack.com/p/creatine-explained-how-one-molecule?r=40ekz2 Sardine Diet Letter: https://staycuriousmetabolism.substack.com/p/sardine-fasting-the-ultimate-health?r=40ekz2 Sardine Diet Video: https://youtu.be/_Th54GWd8WY Lived to 117 Letter: https://staycuriousmetabolism.substack.com/p/the-oldest-woman-117-had-high-cholesterol?r=40ekz2 Lived to 117 Video: https://youtu.be/U7UY8ZPKNlM Stress Makes Sugar Letter: https://staycuriousmetabolism.substack.com/p/stress-makes-sugar-literally-this?r=40ekz2 Stress Makes Sugar Video: https://youtu.be/7ekVEYlKFfE This interview with Professor Dom D’Agostino is one of the most information-dense conversations I’ve had on the channel. We dive into the real science behind melatonin — why it doesn’t suppress your hormones and why its neuroprotective effects might matter more than its sleep benefits. We explore creatine far beyond muscle performance, including its impact on brain energy and cognitive resilience, and how to take it without the GI issues many people experience.We also break down the surprising biology of a verified 117-year-old woman, what her data reveals about longevity, and why factors like mindset, mitochondria, and microbiome may matter more than any single biomarker. And finally, we tackle sardine fasting — why it may be the most elite, nutrient-dense, muscle-sparing fasting protocol available. If you want cutting-edge science translated into practical strategies for metabolic health, brain health, and longevity, this is the episode to watch.Chapters 0:00 – Welcome Back Professor D’Agostino 1:34 – Does Melatonin Suppress Your Hormones?6:27 – Real Benefits of Melatonin8:00 – Creatine for Brain Health10:24 – How to Reduce GI Upset from Creatine14:04 – How Did This Woman Live to 117?30:00 – Sardine Fasting: The Most Elite Form of Fasting#melatonin #creatine #sardines #sardinediet #fasting #longevity #brainhealth #metabolichealth #neuroprotection #omega3 #NickNorwitz #DomDAgostino #StayCurious #nutritionresearch #healthscience #biohacking #antiaging #ketodiet #ketosis #healthoptimization #supplements #exercisephysiology #functionalnutrition #lowcarb #cholesterol #labresults #epigenetics #mitochondria #inflammation #mentalclarity #superfoods #metabolismboost #wellnessjourney #lifespan #healthylonglife Learn more about your ad choices. Visit megaphone.fm/adchoices

Link to paper: https://www.frontiersin.org/articles/10.3389/fendo.2023.1326768/fullAdrian Soto Mota MD PhD Tweet: https://x.com/AdrianSotoMota/status/1737733204734579062?s=20 Learn more about your ad choices. Visit megaphone.fm/adchoices

For all references and even deeper nuances, check out the StayCurious Metabolism letter: https://staycuriousmetabolism.substack.com/p/the-true-story-of-the-cookie-that?r=40ekz2 Oreo vs Statin Paper: https://pubmed.ncbi.nlm.nih.gov/38276308/Lipid Energy Model Paper: https://pubmed.ncbi.nlm.nih.gov/35629964/ What if Oreo cookies could lower cholesterol faster — and more powerfully — than a multi-billion-dollar statin drug? That’s the question I set out to test in a 5-month controlled self-experiment I ran as a Harvard Medical School student. And the results were so shocking they were eventually published in peer-reviewed literature.This video shares the full story — why my LDL cholesterol skyrocketed into the 500s after going ketogenic, the physiology behind the lean-mass hyper-responder phenomenon, and how adding 12 Oreo cookies per day dropped my LDL twice as much as high-dose statin therapy and in one-third of the time.But this isn’t just about cookies…This is a video about challenging assumptions, testing mechanisms, provoking curiosity, and using a viral headline to shine light on a deeply misunderstood physiological phenomenon.Chapters0:00 – I Used Oreo Cookies to Lower My LDL 1:06 – Why My Cholesterol Skyrocketed in the First Place 4:43 – The True Mechanism Behind the LDL Rocket ship7:53 – Why Oreos vs Statin Worked So Well11:00 – What Does this Oreo Cookie Cholesterol Drop Really Mean?12:33 – What is the Risk of High Cholesterol in People Like Me?14:08 – What We Now Know#cholesterol #LDL #hearthealth #metabolism #LMHR #lipidenergymodel #LEM #exercise #ApoB #cardiovasculardisease #obesity #staycurious #VLDL #triglycerides #metabolichealth #educational #metabolichealth #cholesterol #LDL #statins #ketodiet #lipidenergymodel #leanmasshyperresponder #metabolichealth #healthscience #ApoB #nutritionresearch #NickNorwitz #StayCurious #cardiovascularhealth #scienceeducation #cholesterolmyth Learn more about your ad choices. Visit megaphone.fm/adchoices

Prior Response video: https://youtu.be/ILuEO7Jc8TY?si=RCPFWtRDC09Pst5sLMHR CCTA study drop: https://youtu.be/IMkDwtJVeB0?si=yx-zbFnfkLNtZeuLOreovsStatin leak video: https://youtu.be/GHALacs44I8?si=9IOAgZTl3sMnVg6LPeter Libby Review: https://www.nature.com/articles/s41586-021-03392-8Norwitz et al 2021: https://cdn.nutrition.org/article/S2475-2991(22)00007-5/fulltextCooper et al 2023: https://www.frontiersin.org/articles/10.3389/fendo.2023.1326768/full Learn more about your ad choices. Visit megaphone.fm/adchoices

For references and a written breakdown, see the associated Stay Curious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/new-hope-for-alzheimers-can-apoe2?r=40ekz2 Lithium for Brain Health: https://staycuriousmetabolism.substack.com/p/lithium-and-alzheimers-the-harvard?r=40ekz2 Ketone Cleans the Brain, Video: https://youtu.be/oRaNzfHF_do Chapter*Call our service line at 815-STAY-CUR (815-782-9287) *Learn more about the data, here: https://staycuriousmetabolism.substack.com/p/life-or-death-in-the-fine-print-the?r=40ekz2 I carry two copies of APOE4 — the gene variant that increases Alzheimer’s risk 10–15-fold. For years, that terrified me. But emerging research provides hope. The study we will review suggests that adding APOE2 might quiet brain inflammation, reduce plaques, and help save neurons. In today’s video, I break down the research in simple terms and what this could mean for the future of Alzheimer’s therapy. Then I’ll share the evidence-based strategies that I personally use to protect my brain while we wait for next-generation gene therapies: lithium orotate, ketosis, omega-3s, and more.Chapters0:00 – Why I’m Determined to Prevent Alzheimer’s1:28 – An Incredible Picture of Neuroinflammation 2:06 – APOE2, APOE3, APOE4: What These Genes Really Mean3:54 – The Big Question: Is There an Antidote to APOE4?5:36 – APOE2 Therapy: Reduced Plaques and Silenced Neuroinflammation7:19 – Chapter: The Right Insurance Saves Money and Life-Years8:33 – My 3 Neuroprotection Essentials: Lithium, Ketosis and Omega-3s#alzheimersdisease #apoe4 #brainhealth #longevity #dementia #neuroscience #educational #staycurious #Alzheimers #BrainHealth #Neuroinflammation #CognitiveHealth #DementiaPrevention #APOE2 #Genetics #Longevity #Neuroscience #Metabolism #Ketosis #LithiumOrotate #Omega3 #HealthyBrainAging #StayCurious #Neuroprotection #Microglia #Amyloid #BrainOptimization*Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan’s contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don’t directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your options. Learn more about your ad choices. Visit megaphone.fm/adchoices

What I liked: I like the concept of 'bringing the viewer along with the science.' I agree with the fact that the SAD eating pattern is problematic and that it would be an improvement to eat a whole food-based diet. I also (very much) acknowledge there are non-health related issues about food that we should have adult discussions about.What I didn't like: (1) This series wasn't really about the twin study. Data were only presented, a bit, in the last of the 4 episodes. (2) The advertised foods (fake meat, fake cheese, fake eggs) are cast as similar/identical, but simply aren't, nor were they the basis of the participant's diets.(3) The data presented were, I think, not all that impressive. And some data presented in the documentary could not be found in the paper, e.g. body composition.For more on the topic of Data Misrepresentation, see our new paper: https://www.sciencedirect.com/science/article/pii/S002231662372806X?via%3Dihub Learn more about your ad choices. Visit megaphone.fm/adchoices

For a mini-masterclass in blood sugar control, see: https://staycuriousmetabolism.substack.com/p/7-ways-to-lower-blood-sugar-without?r=40ekz2 For the Stress Creates Sugar Letter: https://staycuriousmetabolism.substack.com/p/stress-makes-sugar-literally-this?r=40ekz2 Statin Slash GLP-1 Video: https://youtu.be/6NomrgjK1yQIn this interview, Dr. Nick Norwitz MD PhD sits down once again with Dr. Andrew Koutnik PhD to unpack several groundbreaking research papers, including how psychological stress can cause your liver to make sugar from scratch, how different carbs and fibers impact bodies differently depending on metabolic health, how potatoes can tell you if you’re insulin sensitive, and more. If you’ve ever wondered how stress, nutrition, and biology collide to shape your health, this conversation might change the way you think about your body—and your mind.Chapters:00:00 — The new stress-sugar discovery01:10 — How your brain signals your liver to make glucose04:30 — The real mechanism behind “stress-induced sugar spikes”07:00 — Andrew’s story: TED Talk stress sent glucose up 100 mg/dL10:20 — How sprinting saved him from a glucose crash12:00 — What this means for diabetics and the general population14:30 — Why meditation changes your biology (not just mindset)16:00 — How obesity amplifies stress’s metabolic effects17:00 — The ‘semi-myth’ of fiber protection in insulin resistance21:30 — Personalized nutrition and CGM insights24:00 — Potatoes vs Grapes test for insulin resistance27:00 — GLP-1 dysfunction, statins, and “new species of diabetes”38:00 — The future of metabolic precision medicine#Cortisol #Glucose #BrainHealth #LiverHealth #Type1Diabetes #Type2Diabetes #Hormones #NutritionScience #Mitochondria #HealthOptimization #Neuroscience #Endocrinology #MetabolicFlexibility #LowCarb #KetogenicDiet #FunctionalMedicine #ChronicStress #Biohacking #HealthResearch #ScienceCommunication #Educational #Informative #StayCurious Learn more about your ad choices. Visit megaphone.fm/adchoices

Link: https://pubmed.ncbi.nlm.nih.gov/38237807/0:00: intro 0:15: NEW paper!0:38: Low-Carb for various diseases0:57: LDL boogeyman1:17: Lean Mass Hyper-Responder #LMHR1:35: The BIG question2:11: Intro to NEW study, meta-analysis of RCTs2:46: BMI Results!4:43: Not the Saturated Fat!5:58: Lipid Energy Model 6:56: Conclusion Learn more about your ad choices. Visit megaphone.fm/adchoices

For more nuances and references, see the associated Newsletter: https://staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2 Winnow Microplastic Binding Probiotic, Affiliate Link (15% off): https://www.winnowlabs.com/STAYCURIOUSMost people think of plastic as an environmental problem—something that harms oceans, wildlife, and ecosystems. But emerging science is revealing something far more personal: microplastics don’t just pollute the planet— they may be poisoning your heart.A landmark study published in the New England Journal of Medicine found microplastics and nanoplastics embedded inside human arterial plaque. Even more alarming, patients with these particles inside their arteries had a 350% higher risk of heart attack, stroke, or death.This research suggests microplastics may drive cardiovascular disease through oxidative stress, inflammation, immune activation, and vascular damage. Under the microscope, jagged plastic fragments were found lodged inside macrophages—immune cells that normally clear debris—triggering inflammation and accelerating plaque instability.We also explore what you can do today—from reducing heat-exposed plastics, filtering water, and improving air quality, to emerging research on internal defense strategies aimed at binding microplastics before they’re absorbed. This isn’t fear. It’s empowerment. Knowledge isn’t meant to panic us—it’s meant to protect us. Stay curious.Chapters0:00 – Plastic Poisons the Heart. But There’s Good News!1:15 – Find More Information at StayCurious Metabolism 1:41 – A Landmark NEJM Study 2:42 – 350% Increased Risk of Heart Attack, Stroke and Death!4:15 – Microplastics Associate with Inflammation 5:02 – Microplastics Lodged in Macrophage Immune Cells6:41 – Comparison to LDL Cholesterol 8:15 – How to Reduce Your Exposure to Microplastics9:54 – A Probiotic That Shields You from Microplastics#microplastics #cardiovasculardisease #microbiome #hearthealth #heartdisease #NEJM #microplastics #hearthealth #cardiovasculardisease #nanoplastics #inflammation #science #longevity #metabolichealth #heartattack #stroke #healthscience #NickNorwitz #StayCuriousMetabolism Learn more about your ad choices. Visit megaphone.fm/adchoices