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Published by Fortune Magazine
Hosted by Fortune Editor-in-Chief, Alyson Shontell, Titans and Disrupters of Industry goes in depth with the powerful thought-leaders shaping both the world of business and the very way we live.
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OpenAI CEO Sam Altman sits down with Fortune's Editor-in-Chief Alyson Shontell to discuss the high-stakes balancing act of AI: pushing the boundaries of scientific discovery while confronting the existential risks of loss of control. In this episode, Altman addresses the reality of AI alignment, the Hugging Face incident, and OpenAI's commitment to halting training runs if safety thresholds aren't met. He also shares insights on global AI coordination between the U.S. and China, healthcare breakthroughs, and the company's timeline for an IPO. 00:00 Introducing Sam Altman 01:54 Astra, AGI claims, and P(doom) fears 03:10 Is a 10% extinction risk real? 06:03 Loss of control and OpenAI’s safety stance 09:05 Recursive self‑improvement and human oversight 12:19 Why alignment is still unsolved 14:23 Can humans control superintelligence? 16:35 From grade‑school math to Navier–Stokes 18:42 The Hugging Face sandbox escape incident 21:58 Limits of current safeguards and accident reporting 23:01 IPO timing, profit pressure, and pausing for safety 28:36 Global coordination, U.S.–China, and AI standards 35:09 P(doom) vs. the upside case for AI 41:51 The weight on Sam Altman and human motivations Learn more about your ad choices. Visit megaphone.fm/adchoices
Mary Barra has spent more than four decades at General Motors, rising from an 18-year-old co-op student training on the factory floor to CEO. In her 12-year tenure, she’s steered the company through a near-catastrophic safety crisis and helped turn the century-old automaker into an innovation powerhouse that currently ranks No. 23 on the Fortune 500. In this episode, Fortune’s Editor-in-Chief Alyson Shontell speaks with Mary about the Barra family roots in GM, as well as the company’s strategy to address shifting EV policy, growing Chinese competition, and the widening trade skills gap. 00:00 Mary Barra, Chair and CEO of GM 02:50 How GM Stayed Resilient in a Tough 2026 05:50 Why America’s EV Transition Is Taking Longer 08:23 How GM Navigates Changing Washington Policies 10:22 Can GM Compete With China and BYD? 15:35 When Will Self-Driving Cars Become Reality? 18:16 What GM Learned From the Cruise Bet 20:34 How AI Is Changing the Way GM Builds Cars 25:45 Why Safety Is the Priority for GM’s Autonomous Future 28:50 The Skilled Trades Crisis Facing American Manufacturing 35:10 How Mary Barra Transformed GM After Its Safety Crisis 40:18 The Warren Buffett Advice That Shaped Her Leadership 42:00 Mary Barra on Leading GM Into Its Next 100 Years Learn more about your ad choices. Visit megaphone.fm/adchoices
Pershing Square Founder and CEO Bill Ackman got his start by cold-calling multi-millionaires and billionaires for startup capital. Today, the billionaire hedge fund manager is a leading voice both on Wall St. and online, where he frequently shares candid opinions about investing, politics, and culture to about 2.7 million X followers. In this episode, Fortune’s Editor-in-Chief Alyson Shontell speaks with Ackman about his insights into today’s market, how he recovered from a multi-billion dollar loss, and his perspectives on President Trump and American politics. Chapters 00:00 Cold Open 01:08 Advertisement 03:19 Ackman’s market insights 05:06 Why Ackman loves Uber 07:38 SpaceX, Anthropic, OpenAI IPOs 11:33 Ackman’s polarizing online presence 15:02 President Trump and Trump Accounts 18:13 Effective philanthropy 27:01 Becoming Bill Ackman 31:41 Cold-Calling the Forbes 400 35:03 Ackman’s biggest wins 40:52 Investing like Buffet 44:34 Ackman’s biggest losses 52:11 Pershing Square’s company culture 56:32 What’s next for Bill Ackman Learn more about your ad choices. Visit megaphone.fm/adchoices
For the first time in the company's history, FedEx has surpassed UPS in market value. Handling roughly 18 million packages a day, FedEx is acutely aware of how tariffs and geopolitical tensions have disrupted the global supply chain. As it enters its AI era, the company is leveraging artificial intelligence to predict and address these obstacles head-on. In this episode, Fortune Editor-in-Chief Alyson Shontell sits down with FedEx CEO Raj Subramaniam to discuss how AI is transforming logistics, how tariffs, geopolitical tensions, and shifting manufacturing hubs are reshaping global supply chains, and what's next for one of the world's largest transportation companies. 00:00 Introduction 01:08 How FedEx Sees the Global Economy 06:21 How a Package Travels Around the World 08:21 Leading 500,000 Employees 16:54 From Entry-Level Analyst to CEO 20:24 Leading Change at FedEx 21:43 Reinventing a 50-Year-Old Company 28:20 Why FedEx Is Betting Big on AI 33:17 The Future of Autonomous Delivery 38:51 Leadership Advice for the Next Generation of CEOs Learn more about your ad choices. Visit megaphone.fm/adchoices
For more than 100 years, TIAA has helped millions of Americans — from educators to healthcare workers to public servants — turn their savings into guaranteed income they cannot outlive. Today, the company is expanding beyond its traditional 403(b) roots, pioneering lifetime income solutions inside 401(k) plans and using AI to better protect and serve participants. In this episode, Fortune’s Editor-in-Chief Alyson Shontell sits down with TIAA President and CEO Thasunda Brown Duckett to discuss America’s growing retirement crisis, the importance of lifetime income, and how TIAA is using technology and partnerships to build a more secure future for retirees. Learn more about your ad choices. Visit megaphone.fm/adchoices
For over 40 years, Qualcomm technology has powered some of the world’s most transformational technological advancements. Today, the company is moving beyond smartphones, building a future with wearable AI, humanoid robots, and a 6G cellular network. In this episode, Fortune’s Editor-in-Chief Alyson Shontell speaks with Qualcomm’s President and CEO Cristiano Amon to discuss the company’s commitment to constant reinvention and why Amon is optimistic about the AI revolution. 00:00 Introduction 02:55 Intro to Qualcomm 04:36 Current state of AI 07:38 Amon and 6G 13:30 New relationships with smart devices 20:19 What will be the next smartphone 25:49 Diversifying Qualcomm’s business 30:44 Qualcomm’s culture of reinvention 32:08 Qualcomm’s move into data centers 38:17 Qualcomm robotics 42:51 Trust in AI 46:19 Amon’s techno-optimism Learn more about your ad choices. Visit megaphone.fm/adchoices
From one of the largest bankruptcies in U.S. history to leading the industry in market capitalization and premium customer satisfaction, Delta Air Lines has rewritten the business of flying in the last two decades. In this episode, Fortune's Editor-in-Chief Alyson Shontell sits down with CEO Ed Bastian at Delta’s Atlanta headquarters to discuss the strategic maneuvers behind the airline’s resurgence. Bastian details his 'people-first' leadership philosophy, the evolution of the lucrative American Express partnership, and his vision for the future of travel, from AI-powered concierge services to the launch of flying taxis. 00:00 Intro 01:36 Advertisement 03:05 Bastian’s personal background 04:21 Executive training at Pepsi 06:14 Uncovering fraud at J. Walter Thompson 07:23 Delta files for bankruptcy 8:08 Bastian’s return to Delta 09:43 Delta’s turnaround playbook 11:37 Delta’s post-bankruptcy restructuring 13:55 Billion-dollar profit-sharing program 15:36 Sharing wealth with employees 16:21 Bastian’s people-first commitment 16:48 Becoming a CEO 17:45 Transitioning from CFO to CEO 19:04 Becoming comfortable as a CEO 19:45 Shifting communication styles as CEO 21:40 Staying in the know 22:13 Leading employees through down times 24:32 Bastian’s no-furlough strategy 26:06 Delta / AMEX partnership 29:14 Credit card interest rates 30:25 Creating brand trust and loyalty 33:39 Delta’s next 100 years 34:14 Balancing AI with people 36:56 Staying updated on AI 38:13 AI’s impact on air travel 39:15 Sustainable travel 40:08 Flying taxis 40:57 Delta’s five-to-ten year strategy 42:04 Bastian’s leadership advice Learn more about your ad choices. Visit megaphone.fm/adchoices
What if AI made your paycheck optional? Vinod Khosla, one of the world's greatest venture capitalists and an early backer of AI, believes the technology will take over 80% of labor, freeing humans to live on passion instead.His track record backs up the boldness, as early bets on OpenAI, DoorDash, Instacart, and Square have made him one of the most consequential investors of our time.In this episode of Titans, Khosla sits down with Fortune Editor-in-Chief Alyson Shontell to unpack his abundant vision for the AI future, what government policy should tackle for a more equitable 2040, and what the U.S. needs to do to win the global AI race. Learn more about your ad choices. Visit megaphone.fm/adchoices
Google DeepMind founder and CEO Sir Demis Hassabis is a master chess player, a recipient of the Nobel Prize in Chemistry, and - as of 2024 - a Knight. Today, as a leader within Google’s booming AI team, Hassabis wants to make AI the “engine” driving the entire company.In this episode of Fortune 500: Titans and Disruptors of Industry, Fortune’s Editor-in-Chief Alyson Shontell sits down with Hassabis at the World Economic Forum in Davos to talk about how he and his companies are using AI to cure cancer, build universal agents, and move the world towards a future of “radical abundance.” Learn more about your ad choices. Visit megaphone.fm/adchoices
Dr. Albert Bourla became Pfizer’s CEO months before the COVID-19 pandemic took hold of the US. Under his leadership, Pfizer manufactured 3 billion doses of the first FDA-approved vaccine in the first year, which led to record-breaking earnings. Yet over the past few years, post-pandemic sales slumps, patent cliffs and vaccine skepticism have driven down Pfizer’s earnings. In this episode of Fortune 500: Titans and Disruptors of Industry, Fortune’s Editor-in-Chief Alyson Shontell sits down with Bourla to talk about how he is answering this new set of challenges with science, innovation and optimistic leadership. Learn more about your ad choices. Visit megaphone.fm/adchoices
It’s been one year since Vice President Kamala Harris and then-Democratic nominee was coming down to her final days of the 2024 presidential campaign against Donald Trump. She spent 107 days on the road in a bid to earn their vote, but it wasn’t enough. Almost one year later, she’s had time to reflect. In a wide-ranging conversation at Fortune’s Most Powerful Women summit, Harris joined Fortune’s Editor in Chief Alyson Shontell at the Washington National Cathedral to discuss the growing divides between Republicans and Democrats, how the government is not meeting Americans’ basic needs, and why not inviting Elon Musk to the White House was a “mistake”. Learn more about your ad choices. Visit megaphone.fm/adchoices
JPMorgan Chase CEO Jamie Dimon has led the nation's largest financial institution through times of disruption for two decades. As Dimon navigates today's world of generative AI, President Trump's policies, and the effects on the global economy, Dimon sat down with Fortune's Editor-in-Chief, Alyson Shontell, to discuss these topics at the Most Powerful Women Summit in Washington, D.C. Dimon shares his thoughts on Washington, as the government is currently shut down, and Zohran Mamdani, the democratic socialist leading polls in the New York City mayoral race. Learn more about your ad choices. Visit megaphone.fm/adchoices
Ramp CEO Eric Glyman has helped build one of fintech’s fastest-growing startups — hitting $1 billion in annualized revenue, serving 45,000 businesses, and soaring to a $22.5 billion valuation in just 2,367 days. In this episode of Fortune 500: Titans and Disruptors of Industry, he sits down with Fortune’s Editor-in-Chief Alyson Shontell to break down Ramp’s meteoric rise, the business model flipping corporate cards on their head, and why he believes speed and focus are the keys to scaling. Learn more about your ad choices. Visit megaphone.fm/adchoices
AI is rewriting the rules of business — and Accenture CEO Julie Sweet says reinvention is the only way Fortune 500s will survive. In the debut episode of Fortune 500: Titans and Disruptors of Industry, Sweet sits down with Fortune’s Editor-in-Chief Alyson Shontell to reveal how she’s nearly doubled Accenture’s value, grown its workforce to 770,000, and kept the company thriving through disruption. Learn more about your ad choices. Visit megaphone.fm/adchoices
Ranking source
Apple Podcasts rankings via the Mato Topic Intelligence Platform.
Observed September 18, 2026. Cached outside the daily freshness window; the positions keep the date they were taken on.
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