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The Nutritional Medicine Podcast is the official podcast of the Nutritional Medicine Institute (NMI), an educational, advocacy and research group committed to advancing the science and practice of nutritional medicine. The podcast features interviews with leading scientists, clinicians and advocates of nutritional medicine, including integrative, functional and lifestyle medicine-based approaches. Expert interviews are focused on the role of diet and nutrition, environment, behaviour and lifestyle as determinants of health. We explore science that informs the application of personalised lifestyle, dietary interventions and nutrient-based supplements in clinical practice. Your host is Benjamin Brown, Director of the Nutritional Medicine Institute and expert in personalised nutrition and lifestyle medicine. The contents of the NMI Podcast are for educational purposes and intended for health professionals. This information is not a substitution for standard medical care. Health professionals are solely responsible for the care and treatment provided to their own patients.
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Hormone metabolism is complex, assessment nuanced and management highly personalised, however Dr. Carrie Jones extraordinary expertise and unique, accessible approach has empowered and helped countless clinicians navigate this area. In this conversation Dr. Jones discuses hormone metabolism, testing and how to think about clinical care through the perspective of 'root cause' medicine, including nutritional, lifestyle and behavioural approaches across different life stages. About our guest: Carrie Jones, ND, FABNE, MPH, MSCP is an internationally recognized speaker, consultant, author and educator on women's health and hormones with over 20 years in the industry. Dubbed the "Queen of Hormones" in functional medicine, Dr. Jones is a Naturopathic Physician who completed a two-year residency focused on women's health and endocrinology. She earned her Master of Public Health (MPH), became one of the first to be board certified through the American Board of Naturopathic Endocrinology (FABNE), and is a Menopause Society Certified Practitioner (MSCP). She was the first Medical Director for Precision Analytical (the DUTCH Test), the first Head of Medical Education at Rupa Health (a Fullscript Company) and served on Under Armour's Human Performance Council. She regularly consults and educates for several women's health, supplement, and lab-focused companies. Dr. Jones co-hosted the highly popular Root Cause Medicine Podcast, which has over 10 million downloads and now hosts her own podcast, Hello Hormones. Guest websites and links: www.drcarriejones.com Selection of our guest's publications: https://www.drcarriejones.com/articles
Sometimes we are privileged enough to engage in conversations with sages that, through experience and time, have arrived at profound and novel realisations that challenge our world view. This is one of those conversations. Professor Mark L Wahlqvist has been involved in paradigm sifts in nutrition and medicine, including but not limited to the discovery of foods phytoestrogenic effects, the inflammatory basis of macrovascular disease, and the relationship between food patterns, dietary diversity and health outcomes. We explore his pioneering work and the larger themes of the interconnected relationship between human health, diet, regional ecosystems (eco nutrition) and cosmology (quantum nutrition). About our guest: Professor Wahlqvist was educated at Adelaide and Uppsala Universities. He is a Consultant Physician and has held chairs in Human Nutrition, Medicine, Epidemiology and Preventive Medicine at Melbourne's Deakin and Monash Universities. He has been Chair of Internal Medicine at Prince Henry's Hospital, then of the Monash Medical Centre in Melbourne, as well as Director of the APHNC (Asia Pacific Health & Nutrition Centre) at the MAI (Monash Asia Institute) and of the FAO Centre of Excellence in Food Safety at Monash University. He has also held appointments at the Karolinska Institute in Sweden, the University of Indonesia and Zhejiang University in China. He was President of the International Union of Nutritional Sciences (IUNS), Chair of the Australian Nutrition Foundation (Nutrition Australia), Foundation Chair of the WMCACA (Weight Management Code Administration Council of Australia), a Board member of ANZFA, the Australian and New Zealand Food Authority (now FSANZ), Foundation Chair of the Food Safety Council of Victoria, Chair of the Australian Academy of Science National Nutrition Committee, and Foundation Editor-in-Chief of the Asia Pacific Journal of Clinical Nutrition. His advisory board memberships have included the Harvest Plus program (International Food Policy Research Institute in Washington DC), the Riddet Food Research Institute at Massey University, New Zealand and the WHO Nutrition Advisory panel. He has been recognised with awards by the nutrition societies in Australia, Britain, the USA, Taiwan, Indonesia and China. He was awarded the Charlotta Medal by the Swedish Emigrants Research Institute and made an honorary Bataknese. Guest websites and links: https://www.researchgate.net/profile/Mark-Wahlqvist-3 Selection of our guest's publications: Gallegos D, Wattanapenpaiboon N, Wahlqvist ML. Food and Nutrition Sustainable Food and Health Systems (5 th Edition). 2026, Routledge. Wahlqvist ML, Wattanapenpaiboon N, Shuai M, Liu HY, Zhong L, Zheng JS. Quantum food and nutrition: Subatomic approaches to nourishment for health and well-being. Asia Pac J Clin Nutr. 2025 Feb;34(1):1-9. Wahlqvist ML. Imagining a habitable planet through food and health. Eur J Clin Nutr. 2021 Feb;75(2):219-229. Wahlqvist ML. Future food. Asia Pac J Clin Nutr. 2016 Dec;25(4):706-715. Wahlqvist ML. Ecosystem Health Disorders - changing perspectives in clinical medicine and nutrition. Asia Pac J Clin Nutr. 2014;23(1):1-15. Wahlqvist ML, Specht RL. Food variety and biodiversity: Econutrition. Asia Pac J Clin Nutr. 1998 Dec;7(3/4):314-9.
Chronic migraine is a debilitating, poorly understood and poorly managed illness due to limited clinical options. Dr. Kyle Bills is a neuroscientist and clinician specializing in migraine who has been involved in the characterisation of unique phenotypes related to glucose dysregulation that may help guide more effective, personalised treatments. The discussion includes his remarkable clinical research utilizing continuous blood glucose monitoring (CGM) and a ketogenic diet. About our guest: Dr. Kyle Bills, DC, PhD, is a neuroscientist and clinician specializing in migraine, brain injury, and addiction recovery. Dr. Bills serves as Associate Dean for Research and Associate Professor of Neuroscience at Noorda College of Osteopathic Medicine, where he helped build the institution from the ground up. His leadership includes launching the research program, establishing the Academic Research Clinic, developing a four-year student research curriculum, and helping the college achieve full accreditation. He founded and directs both the Migraine and Neurological Research Center and the Academic Research Clinic, leading a research lab of over 40 medical students studying chronic migraine, generalized anxiety disorder, substance use disorder, and glucose dysregulation. He earned his Ph.D. in Neuroscience from Brigham Young University and his Doctor of Chiropractic (D.C.) from Parker University in Dallas. His post-doctoral fellowship at BYU was funded by the National Institutes of Health (NCCIH), and his clinical training included work at the Dallas VA Medical Center. Dr. Bills also holds faculty appointments with BYU, Parker University, Roseman University, and Rocky Mountain University, where he has taught courses in physiology, neuroanatomy, neurobiology, neurology, and manual medicine. Guest websites and links: https://migraineandneurorehabcenter.com Selection of our guest's publications: Nelson CA, Reavely KW, Jennings MR, Burger BJ, Kim AC, Sant DW, Bills KB. Glucose dysregulation and glycemic phenotyping in chronic migraine. Front Neurol. 2026 Jan 14;16:1719724. Amendolara A, Magoffin WD, Naik AU, Sant D, Kriak J, Green B, Bills K. Chronic Migraine May Be Associated With Postprandial Hypoglycemia in Adult Men: A Case Series. Cureus. 2024 Feb 26;16(2):e54987. Hill A, Amendolara AB, Small C, Guzman SC, Pfister D, McFarland K, Settelmayer M, Baker S, Donnelly S, Payne A, Sant D, Kriak J, Bills KB. Metabolic Pathophysiology of Cortical Spreading Depression: A Review. Brain Sci. 2024 Oct 16;14(10):1026.
Long covid is a poorly understood and poorly studied illness that is associated with millions missing, that is millions of people suffering with little support or hope. A better understanding of the biology and complexity of long covid could lead to individualised treatments and is an important opportunity for the functional medicine model. Join Dr. Ciara Wright and hear about her own personal, research and clinical experience, which gives us hopefulness for better care and recovery. About our guest: Dr. Ciara Wright is a science researcher and Nutritional Therapist. With a background in medical laboratory sciences and biology, Ciara obtained her PhD in epithelial immunology and worked post-doctorally in diverse research fields such as stem cell science, gene therapy, microbiology and immunology. She published a number of translational science papers and mentored PhD students during this time. After studying with the Institute of Health Sciences, Ciara now also runs a busy Nutritional Therapy practice in Ireland. She specialises in fertility, immunology and complex fatigue conditions and is an expert in functional medicine testing for the management of chronic illness. Ciara keeps up to date with the latest research and manages her clinical team at Positive Nutrition, ensuring an evidence-based practice and the best supports for her patients. Ciara continues her research with several collaborators, including a clinical trial on nutritional intervention in NAFLD, publishing nutritional reviews and case reports, and contributing to a book chapter on nutritional interventions for male fertility. Ciara has delivered lectures and spoken at international medical conferences in Ireland, UK, Europe and Africa. Most recently, Ciara has overcome personal illness with Long Covid and Lyme disease. This experience has deepened her engagement with scientists and patient-led groups, helping to raise awareness and advance research into these complex conditions. She has published a case study on her own treatment and now collaborates with leading researchers in the field. As a way of giving back, she offers pro-bono support to severely affected chronically ill patients, while Positive Nutrition can offer some financial supports to provides access to functional medicine testing. Guest websites and links: https://positivenutrition.ie Selection of our guest's publications: Remote Self-Measurements of Waking Blood Lactate Correlate with Post-Exertional Malaise: Results From "The Acid Test" Prepublication 2026, Presenting at American Physical Therapy Association Combined Sections Meeting Feb 2026. Wright C, et al. Treatment of Long COVID With Enoxaparin. Cardiopulmonary Physical Therapy Journal 36(1):p 70-73, January 2025.
This remarkable conversation with Dr. Alex Richardson covers the development of her research that was some of the first to demonstrate the influence of food and nutrition on mood and behaviour. Dr. Richardson has been hugely influential in putting nutrition for mental health on the map, especially in areas such as dyslexia, dyspraxia, ADHD, depression and schizophrenia. From genetics, biochemistry, and nutrition to physiological and psychological functioning, we explore diverse themes relevant to everyone. About our guest: Dr Alex Richardson is a world-renowned researcher, educator, speaker and published author; and the Founder Trustee and Scientific Director of the UK-based charity, Food and Behaviour (FAB) Research. Based at the University of Oxford for 30 years, the impact of her 90+ peer-reviewed publications places Dr Richardson in the top 3% of academic researchers worldwide. In addition to her work for FAB, she is currently a Visiting Research Fellow at the University of Bournemouth, Research Consultant for the Centre of Nutrition and Behaviour at the Rotherham, Doncaster and South Humberside NHS Trust, and research collaborator with the Dept of Psychology at the University of Swansea. Alex is best known for her research into how nutrition (particularly fatty acids) can affect behaviour, learning and mood, as her pioneering clinical trials were the first to show that dietary supplementation with omega-3 (and omega-6) fats can improve behaviour and learning in children with dyslexia, dyspraxia, ADHD and related conditions; and that this approach may also help many other children without such diagnoses. She also published some of the earliest reports of successful nutritional approaches to both depression and schizophrenia in young adults, which have subsequently been confirmed and extended by others. Her work has always been highly inter-disciplinary and collaborative, involving several large-scale collaborative programmes that include studies of epidemiology, genetics, brain imaging, biochemistry and nutrition as well as physiological and psychological functioning. Her main interests centre on the role of nutrition in brain health, and its implications for behaviour, learning and mood, particularly in relation to: neurodevelopment, mental health, links between mental and physical health. Alex's research has also always been primarily aimed at developing new methods of identification and management that will have real practical benefit. In addition to her role as a founder director of FAB Research, she also helped to found the Dyslexia Research Trust, was a co-opted Trustee and Scientific Advisor to the Dyspraxia Foundation, served on the Biomedical Research Committee of Autism Unravelled, and liaised closely with the Hyperactive Children's Support Group, among many others. Guest websites and links: https://www.fabresearch.org Selection of our guest's publications: Montgomery P, Burton JR, Sewell RP, Spreckelsen TF, Richardson AJ. Fatty acids and sleep in UK children: subjective and pilot objective sleep results from the DOLAB study--a randomized controlled trial. J Sleep Res. 2014 Aug;23(4):364-88. Richardson AJ, Burton JR, Sewell RP, Spreckelsen TF, Montgomery P. Docosahexaenoic acid for reading, cognition and behavior in children aged 7-9 years: a randomized, controlled trial (the DOLAB Study). PLoS One. 2012;7(9):e43909. Richardson A. They Are What You Feed Them: How Food Can Improve Your Child's Behaviour, Learning and Mood. Harper. 2010. Cyhlarova E, Montgomery P, Ross MA, Richardson AJ. Niacin skin test response in dyslexia. Prostaglandins Leukot Essent Fatty Acids. 2007 Aug;77(2):123-8. Richardson AJ, Puri BK. A randomized double-blind, placebo-controlled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficulties. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Feb;26(2):233-9.
For over 30-years, Dr Greenblatt has been practicing, researching and educating health providers on the role of personalised nutrition in psychiatry and remains at the forefront of this important area. His new book Finally Hopeful: The Personalized, Whole-Body Plan to Find and Fix the Root Causes of Your Depression is a landmark contribution and will transform people's lives while highlighting the power of personalised, evidence-based nutrition practice to improve mental health care. Guest: Dr. James Greenblatt About our guest: James Greenblatt, MD, is a globally recognized pioneer in functional and integrative psychiatry with over 30 years of clinical experience. He has dedicated his career to transforming the treatment of mental health disorders through precision-based approaches that integrate laboratory testing, nutritional interventions, and root-cause analysis. Dr. Greenblatt earned his medical degree and completed a psychiatry residency at George Washington University, and pursued a Child and Adolescent Psychiatry fellowship at Johns Hopkins Medical School. A prolific author, Dr. Greenblatt has written nine books, including his newest title, Finally Hopeful: The Personalized, Whole-Body Plan to Find and Fix the Root Causes of Your Depression , and the bestseller Finally Focused: The Breakthrough Natural Treatment Plan for ADHD . He serves as an Assistant Clinical Professor of Psychiatry at Tufts University School of Medicine and Dartmouth College's Geisel School of Medicine. Previously, he served as Chief Medical Officer for Walden Behavioral Care/Monte Nido, a national mental health organization specializing in eating disorders. In 2019, Dr. Greenblatt founded Psychiatry Redefined , a leading platform for continuing education for clinicians in functional and integrative psychiatry, designed to bridge critical knowledge gaps for mental health professionals. Guest websites and links: https://www.jamesgreenblattmd.com https://www.psychiatryredefined.org/ Selection of our guest's publications: Greenblatt J, Gottlieb B. Finally Hopeful: The Personalized, Whole-Body Plan to Find and Fix the Root Causes of Your Depression. Penguin Random House. 2026. Greenblatt J, Dimino JC. Functional Medicine for Antidepressant Withdrawal. FriesenPress. 2022. Greenblatt J. Finally Focused: The Breakthrough Natural Treatment Plan for ADHD. Harmony. 2017.
Dr Miguel is a remarkable scientist in that he gracefully bridges the worlds of research, education, clinical practice, public outreach and compassion in his work. This interview explores topics relevant to the translation of science to real world relevance in an authentic, compassionate and humanistic way. We also explore his new book ADHD Body and Mind: A Compassionate Guide to Rewilding Your Nervous System with Neuroscience, Nutrition, and Gut-Brain Health. Guest: Dr. Miguel Toribio-Mateas About our guest: Dr. Miguel Toribio-Mateas is a clinical neuroscientist, applied microbiologist, and nutritionist with over 25 years of experience in healthcare, science, and technology. His research explores the microbiota-gut-brain axis, investigating how diet and lifestyle influence mood, cognition, and behaviour. With a doctorate in gut microbiome and mental health, his work has earned recognition, including the prestigious Santander Universities Work-Based Learning Award in 2016 and publication in peer-reviewed journals like the BMJ . Dr. Miguel has led transdisciplinary research projects, designing and overseeing clinical trials that examine the role of nutrition in psychiatric and neurodevelopmental conditions. He previously held a five-year research fellowship at London South Bank University, focusing on gut health's impact on cognitive function and mental wellbeing. Currently, he is part of a multi-centre team evaluating natural approaches to ADHD management and holds an Honorary Research Fellowship at Cardiff University's School of Psychology. Alongside his research, he is a lecturer in nutrition at the University of West London, where his work focuses on quality improvement in public health interventions and their interface with gut and brain health. He is has a self-compassionate guide to the neuroscience of ADHD, which will be published in April 2026 by Jessica Kingsley Publishers. Through his research, teaching, and writing, Dr. Miguel empowers individuals to make informed, evidence-based dietary choices that nurture both body and mind—always with the understanding that self-care is not about perfection, but about kindness and adaptability. Guest websites and links: https://drmiguelmateas.com https://www.instagram.com/drmiguelmateas Selection of our guest's publications: Toribio-Mateas M. ADHD Body and Mind: A Compassionate Guide to Rewilding Your Nervous System with Neuroscience, Nutrition, and Gut-Brain Health. Jessica Kingsley Publishers. 2026. Lawrence K, Fibert P, Toribio-Mateas M, Gregory AM, Hobbs J, Quadt F, Wright S, Cotter PD, Patel S, Myrissa K. Effects of kefir on symptoms, sleep, and gut microbiota in children with ADHD: a randomised controlled trial. BMC Psychiatry. 2025 Nov 24;25(1):1117. Toribio-Mateas M, Noble G. Making Room for Every Voice: Reimagining Person-Centred Care in the Neurosciences. Health Expect. 2025 Aug;28(4):e70350. Lawrence K, Fibert P, Hobbs J, Myrissa K, Toribio-Mateas MA, Quadt F, Cotter PD, Gregory AM. Randomised controlled trial of the effects of kefir on behaviour, sleep and the microbiome in children with ADHD: a study protocol. BMJ Open. 2023 Dec 7;13(12):e071063. Toribio-Mateas MA, Bester A, Klimenko N. Impact of Plant-Based Meat Alternatives on the Gut Microbiota of Consumers: A Real-World Study. Foods. 2021 Aug 30;10(9):2040. Shevlyakov A, Nikogosov D, Stewart LA, Toribio-Mateas M. Reference values for intake of six types of soluble and insoluble fibre in healthy UK inhabitants based on the UK Biobank data. Public Health Nutr. 2021 Jun 9:1-15. Toribio-Mateas M. Harnessing the Power of Microbiome Assessment Tools as Part of Neuroprotective Nutrition and Lifestyle Medicine Interventions. Microorganisms. 2018 Apr 25;6(2):35.
Who literally wrote the book on nutritional medicine? Dr Alan Gaby. In this interview, Dr Gaby talks about his pioneering work that ultimately resulted in the publication of what is arguably the most important reference text in the field: Nutritional Medicine, Third Edition 2023. In addition, he discusses nutritional therapies that are clinically very useful but broadly overlooked including potassium magnesium aspartate for fatigue, r iboflavin for migraine prevention and identifying hidden food allergies for treating various conditions. About our guest: Dr. Gaby received his undergraduate degree from Yale University, his M.S. in biochemistry from Emory University, and his M.D. from the University of Maryland. He was in private practice for 19 years, specializing in nutritional medicine. He is past-president of the American Holistic Medical Association and has given expert testimony to the White House Commission on Complementary and Alternative Medicine on the cost-effectiveness of nutritional supplements. He is the author of Preventing and Reversing Osteoporosis (Prima, 1994) and The Doctor's Guide to Vitamin B6 (Rodale Press, 1984), and is co-author of The Patient's Book of Natural Healing (Prima, 1999). Dr. Gaby has written numerous scientific papers in the field of nutritional medicine. He was the contributing medical editor for the Townsend Letter for Doctors from 1985 to 2023 and was contributing editor for Alternative Medicine Review from 1996 to 2010. Over the past 43 years, Dr. Gaby has developed a computerized database of more than 28,000 individually chosen medical journal articles related to the field of natural medicine. He was professor of nutrition and a member of the clinical faculty at Bastyr University in Kenmore, WA, from 1995 to 2002. In 2010, Dr. Gaby completed a 30-year project: the textbook Nutritional Medicine . The second edition of Nutritional Medicine was completed in 2017 and the updated third edition was completed in 2023. Nutritional Medicine by Dr. Alan R. Gaby is a science-based, extensively referenced textbook written for healthcare practitioners and for non-practitioners who are interested in viable alternatives to conventional medicine. The textbook discusses hundreds of nutritional therapies that can be used as effective, low-cost, low-risk alternatives or adjuncts to conventional medicine. Guest websites and links: https://doctorgaby.com Selection of our guest's publications: Gaby AR. Nutritional Medicine, Third Edition. Fritz Perlberg Publishing. 2023. Gaby AR. Is There an Epidemic of Research Fraud in Natural Medicine? Integr Med (Encinitas). 2022 May;21(2):14-18. Gaby AR. Adverse effects of dietary fructose. Altern Med Rev. 2005 Dec;10(4):294-306. Gaby AR. The role of hidden food allergy/intolerance in chronic disease. Altern Med Rev. 1998 Apr;3(2):90-100. Editor's note: Connection was lost during the interview in two places. The reference to a vitamin for arthritis referred to niacinamide (see Osteoarthritis page 699, in Gaby A, Nutritional Medicine, Third Edition 2023).
Cardiometabolic disorders are the leading cause of morbidity and mortality yet can largely be prevented with diet and lifestyle medicine. Why is there a gap between this epidemic and more effective treatment? Dr. Bradley discusses his clinical research on feasible, cost-effective, efficacious interventions and wider topics around personalised whole person care and ' disruptive innovation' for health promotion. Guest: Dr. Ryan Bradley, ND, MPH About our guest: Dr. Bradley is an Associate Professor in the University of California, San Diego Herbert Wertheim School of Public Health and Human Longevity Science in La Jolla, CA. His commitment to research is to improve the health of the public through rigorous research on non-drug treatments. Dr. Bradley received his ND in naturopathic medicine from Bastyr University in 2003, and his MPH in Epidemiology from the University of Washington in 2009. He completed NIH-funded T32 research training in complementary medicine at Bastyr University and KL2 training in clinical research at the University of Washington in the Division of Cardiology. His research interests include clinical trials of natural products and mind-body therapies in chronic inflammatory conditions including heart disease, type 2 diabetes, pain, and inflammatory bowel disease, plus cardiovascular epidemiology related to natural products, e.g., cannabis, and heart disease risk. Dr. Bradley has conducted a wide-variety of clinical and observational research, including: cardiovascular epidemiology in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort; observational research and clinical trials on practice outcomes from integrating naturopathic medicine and conventional medicine for type 2 diabetes and cardiovascular disease; clinical trials of natural products (including vitamin D, marine oils, xanthohumol, mixed-carotenoids, and quercetin) and mind-body interventions including qigong for type 2 diabetes. He has published in leading peer-reviewed medical journals including: Journal of Alzheimer's Disease, Aging, Atherosclerosis, the Canadian Medical Association Journal, and the Journal of Clinical Endocrinology and Metabolism. Guest websites and links: https://www.researchgate.net/profile/Ryan-Bradley-7 Selection of our guest's publications: Harnett JE, Rickwood C, Steel A, Bradley R. Naturopathic practitioners' approach to caring for people with cardiovascular disease risk factors: A cross-cultural cross-sectional study reporting the providers perspective. Complement Ther Clin Pract. 2022 Feb;46:101511. Anderson CAM, Bradley R. The potential of novel plant protein foods to improve dietary patterns and markers of cardiovascular health. Am J Clin Nutr. 2020 Nov 11;112(5):1151-1152. Steel A, Rickwood C, Bradley R, Foley H, Harnett JE. Australian Naturopaths' Approach to Caring for People with Cardiovascular Disease and Associated Risk Factors: A Qualitative Study of the Providers' Perspective. J Altern Complement Med. 2020 Oct;26(10):902-910. Bradley R, Harnett J, Cooley K, McIntyre E, Goldenberg J, Adams J. Naturopathy as a Model of Prevention-Oriented, Patient-Centred Primary Care: A Disruptive Innovation in Health Care. Medicina (Kaunas). 2019 Sep 18;55(9):603. doi: 10.3390/medicina55090603. PMID: 31540415; PMCID: PMC6780388. Seely D, Szczurko O, Cooley K, Fritz H, Aberdour S, Herrington C, Herman P, Rouchotas P, Lescheid D, Bradley R, Gignac T, Bernhardt B, Zhou Q, Guyatt G. Naturopathic medicine for the prevention of cardiovascular disease: a randomized clinical trial. CMAJ. 2013 Jun 11;185(9):E409-16. Neuendorf R, Corn J, Hanes D, Bradley R. Impact of Food Immunoglobulin G-Based Elimination Diet on Subsequent Food Immunoglobulin G and Quality of Life in Overweight/Obese Adults. J Altern Complement Med. 2019 Feb;25(2):241-248. Bradley R, Sherman KJ, Catz S, Calabrese C, Oberg EB, Jordan L, Grothaus L, Cherkin D. Adjunctive naturopathic care for type 2 diabetes: patient-reported and clinical outcomes after one year. BMC Complement Altern Med. 2012 Apr 18;12:44. doi: 10.1186/1472-6882-12-44.
The concepts of 'lifestyle psychiatry,' and 'nutritional psychiatry' are transforming the way we think about mental health and wellbeing. Professor Joseph Firth shares his influential work in this area and its implications for changing clinical practice and health policy. We also discuss the digital environment as a newly evolving lifestyle factor that influences mental health. About our guest: Dr. Firth is Professor of Psychology & Mental Health, University of Manchester, Manchester, U.K, with a PhD (Medicine) from The University of Manchester. Internationally recognized as one of the most highly-cited scientists in Digital Medicine, Lifestyle Psychiatry and Mental Health, he was awarded the USERN Laureate in Social Sciences in 2022 and named Research.com's #1 "Rising Star" in 2023. A five-time recipient of the Clarivate™ Highly Cited Researcher award (2020–2024), he has published over 300 articles with more than 45,000 citations (h-index = 90), including first-author papers in top journals like The BMJ and The Lancet Psychiatry. His current research leverages digital technologies and lifestyle medicine to improve outcomes for people with mental illness, and he is currently leading a multi-million £ UKRI-funded project around the implementation of digital lifestyle interventions into youth mental healthcare. Dr. Firth also leads the Lancet Commission on Physical Health in Mental Illness, and acts as expert advisor for the World Health Organization's "Guidelines on Physical Activity and Sedentary Behaviour". He has also engaged extensively with traditional and online media, with his publications around lifestyle and nutritional approaches to mental illness receiving coverage from >700 news outlets (including Times, Forbes, CNN, etc.) along with televised interviews on Sky News and BBC television. Guest websites and links: https://research.manchester.ac.uk/en/persons/joseph.firth Selection of our guest's publications: Brinsley J, O'Connor EJ, Singh B, et al. Effectiveness of Digital Lifestyle Interventions on Depression, Anxiety, Stress, and Well-Being: Systematic Review and Meta-Analysis. J Med Internet Res. 2025 Mar 20;27:e56975. Marx W, Lane M, Hockey M, et al. Diet and depression: exploring the biological mechanisms of action. Mol Psychiatry. 2021 Jan;26(1):134-150. Firth J, Gangwisch JE, Borisini A, Wootton RE, Mayer EA. Food and mood: how do diet and nutrition affect mental wellbeing? BMJ. 2020 Jun 29;369:m2382. Firth J, Solmi M, Wootton RE, et al. A meta-review of "lifestyle psychiatry": the role of exercise, smoking, diet and sleep in the prevention and treatment of mental disorders. World Psychiatry. 2020 Oct;19(3):360-380. Firth J, Teasdale SB, Allott K, et al. The efficacy and safety of nutrient supplements in the treatment of mental disorders: a meta-review of meta-analyses of randomized controlled trials. World Psychiatry. 2019 Oct;18(3):308-324. Firth J, Marx W, Dash S, et al. The Effects of Dietary Improvement on Symptoms of Depression and Anxiety: A Meta-Analysis of Randomized Controlled Trials. Psychosom Med. 2019 Apr;81(3):265-280. Firth J, Veronese N, Cotter J, et al. What Is the Role of Dietary Inflammation in Severe Mental Illness? A Review of Observational and Experimental Findings. Front Psychiatry. 2019 May 15;10:350. Firth J, Stubbs B, Sarris J, et al. The effects of vitamin and mineral supplementation on symptoms of schizophrenia: a systematic review and meta-analysis. Psychol Med. 2017 Jul;47(9):1515-1527.
Dr Adrian Lopresti shares important clinical insights from his published research on natural products such as saffron, ashwagandha, curcumin and magnesium on anxiety, depression and insomnia. He also discusses personalised Integrative therapy, a holistic treatment model he has pioneered that places the use of natural products in the wider context of lifestyle medicine and nutritional psychiatry. About our guest: Dr Adrian Lopresti is the managing director at Clinical Research Australia, a clinical psychologist, and an adjunct senior lecturer at Murdoch University, Western Australia. He regularly publishes in peer-reviewed, high-impact journals and has completed more than 50 clinical trials investigating the effects of ingredients such as saffron, ashwagandha, curcumin, lutein, bacopa monnieri, magnesium, probiotics, and holy basil on anxiety, depression, insomnia, cognitive decline, osteoarthritis, digestive conditions, and general wellbeing in children and adults. Dr Lopresti also has over 25 years of clinical experience working with children and adults experiencing a range of mental health conditions and has extensive experience in utilising psychological, nutritional and lifestyle treatments. Dr Lopresti is also the founder of Personalised Integrative Therapy, a holistic treatment for depression and anxiety, and regularly conducts workshops both nationally and internationally. Guest websites and links: https://clinicalresearch.com.au https://pitherapy.com.au Selection of our guest's publications: Schuster J, Cycelskij I, Lopresti A, Hahn A. Magnesium Bisglycinate Supplementation in Healthy Adults Reporting Poor Sleep: A Randomized, Placebo-Controlled Trial. Nat Sci Sleep. 2025 Aug 30;17:2027-2040. Lopresti AL, Smith SJ, Metse AP, Drummond PD. Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: a randomized, double-blind, placebo-controlled trial. J Clin Sleep Med. 2020 Jun 15;16(6):937-947. Smith SJ, Lopresti AL, Fairchild TJ. Exploring the efficacy and safety of a novel standardized ashwagandha ( Withania somnifera ) root extract (Witholytin®) in adults experiencing high stress and fatigue in a randomized, double-blind, placebo-controlled trial. J Psychopharmacol. 2023 Nov;37(11):1091-1104. Lopresti AL, Smith SJ, Metse AP, Foster T, Drummond PD. The Feasibility and Efficacy of a Brief Integrative Treatment for Adults With Depression and/or Anxiety: A Randomized Controlled Trial. J Evid Based Integr Med. 2020 Jan-Dec;25:2515690X20937997. Sarris J, Ravindran A, Yatham LN, et al. Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce. World J Biol Psychiatry. 2022 Jul;23(6):424-455. Lopresti AL. The Problem of Curcumin and Its Bioavailability: Could Its Gastrointestinal Influence Contribute to Its Overall Health-Enhancing Effects? Adv Nutr. 2018 Jan 1;9(1):41-50. Lopresti AL, Maker GL, Hood SD, Drummond PD. A review of peripheral biomarkers in major depression: the potential of inflammatory and oxidative stress biomarkers. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jan 3;48:102-11.
Coenzyme Q10 has established use across both primary and secondary deficiency diseases. In this episode, Dr. Iain P. Hargreaves, PhD, an eminent scientist working on CoQ10, walks us through its history, functions, his work looking at blood brain barrier transport, clinical considerations around testing and supplementation, and where research is going in the future. About our guest: Dr. Iain P. Hargreaves, PhD is Senior Lecturer in Clinical Biochemistry / Honorary Consultant Clinical Scientist at the Neurometabolic Unit, National Hospital, Queen Square, London, UK School of Pharmacy, Liverpool John Moores University, Liverpool, UK. Following his completion of a PhD in biochemistry at Liverpool University, UK he worked for Prof. Simon Heales and Dr. John Land at the Institute of Neurology, University College of London, London, UK where he was involved in the establishment of the Neurometabolic Unit which specialises in the diagnosis of metabolic disease, especially mitochondrial and neurotransmitter disorders. Dr Hargreaves worked in the Neurometabolic Unit for 21 years until he left to take up a lecturing position in biochemistry/clinical biochemistry at Liverpool John Moores University, Liverpool, UK. Dr Hargreaves has retained an honorary consultant clinical scientist and senior lecturer position within the Neurometabolic Unit and Institute of Neurology, respectively and is still actively involved in the mitochondrial diagnostic service. Dr Hargreaves is editor of Coenzyme Q10: From Fact to Fiction (2015), Mitochondrial Respiratory Chain Disorders: From Clinical Presentation to Diagnosis and Treatment (2019) and author of 160 peer-review research papers. Guest websites and links: https://www.researchgate.net/profile/Iain-Hargreaves Selection of our guest's publications: Mantle D, Dewsbury M, Hargreaves IP. The Ubiquinone-Ubiquinol Redox Cycle and Its Clinical Consequences: An Overview. Int J Mol Sci. 2024 Jun 20;25(12):6765. Mantle D, Hargreaves IP, Domingo JC, Castro-Marrero J. Mitochondrial Dysfunction and Coenzyme Q10 Supplementation in Post-Viral Fatigue Syndrome: An Overview. Int J Mol Sci. 2024 Jan 1;25(1):574. Mantle D, Hargreaves I. Coenzyme Q10 and the Blood-Brain Barrier: An Overview. J Clin Med. 2025 Apr 16;14(8):2748. Staiano C, García-Corzo L, Mantle D, Turton N, Millichap LE, Brea-Calvo G, Hargreaves I. Biosynthesis, Deficiency, and Supplementation of Coenzyme Q. Antioxidants (Basel). 2023 Jul 21;12(7):1469. Mantle D, Heaton RA, Hargreaves IP. Coenzyme Q10, Ageing and the Nervous System: An Overview. Antioxidants (Basel). 2021 Dec 21;11(1):2.
Neurodegenerative diseases, including Motor Neurone Disease (MND)/Amyotrophic Lateral Sclerosis (ALS), Parkinson's Disease and Huntington's Disease, are generally considered progressive and irreversible, but a personalised, systems biology-based approach could challenge this view. A better understanding of the biology, modifiable contributors, and the use of personalised nutritional medicine is radically changing the way we think about neurodegenerative disease, and in this episode Dr. Kirstie Lawton, PhD explains why. About our guest: Dr. Kirstie Lawton, PhD is an AfN registered Nutritionist, a BANT registered Nutritionist, and a CNHC registered Nutritional Therapist, with a nutrition career spanning more than 20 years. She obtained a BSc Hons in Public Health Nutrition and a PhD in Nutrition from Queen Margaret University in Edinburgh, and a DipION in Nutritional Therapy from the Institute for Optimum Nutrition in Richmond, London. She obtained a PGCE in Higher Education at the University of London to support her academic role. She is also completing an MSc in Neuroscience and Neurodegeneration through the University of Sheffield School of Medicine and Population Health. In addition to her clinical role, Kirstie was integral in the establishment of the UK's first level 6 Graduate Diploma in Integrative Functional Nutrition at the Institute for Optimum Nutrition in collaboration with Portsmouth University, which was developed to support medical doctors, allied and complementary healthcare practitioners, to understand and incorporate functional nutritional concepts into their current practice. She is also a member of the editorial board of the Nutritional Medicine Institute (NMI) and journal. Her interest in brain health is based on her own experience with a seemingly undiagnosable range of neurological symptoms, which have improved through diet, lifestyle and nutraceutical support. She is currently focusing her clinical work on diet and lifestyle approaches to support those with Motor Neurone Disease (MND)/Amyotrophic Lateral Sclerosis (ALS), Parkinson's Disease and Huntington's Disease. Guest websites and links: https://www.younutritionclinic.com/ Additional publications: Crayle J, Lutz M, Raymond J, Mehta P, Bedlack R. Study of "ALS reversals": LifeTime environmental exposures (StARLiTE). Amyotroph Lateral Scler Frontotemporal Degener. 2023 Feb;24(1-2):54-62. Okun MS, Dorsey R. The Parkinson's Plan: A New Path to Prevention and Treatment. PublicAffairs. 2025. Dedication: Dr. Lawton would like to dedicate this episode to Ray Griffiths (1959-2025), who's work on Parkinsons disease inspired her own and was important for laying foundations for a systems-based approach to personalised nutrition and lifestyle medicine for neurodegenerative disease.
Genetic testing can help guide highly individualised diet and lifestyle medicine-based interventions and is also highly motivational. We meet Dr Denise Furness, a pioneer and thought leader on nutrigenomics and hear how she started in research and extended into clinical work and education for health professionals focusing on the role of genomics in nutritional and lifestyle medicine. Our discussion includes foundational concepts around nutrigenomics in clinical practice and her recent BIO AGE study. Guest: Dr. Denise Furness, PhD About our guest: Dr. Denise Furness PhD is a pioneer in the field of nutrigenomics and personalised health with almost 20 years' experience in the area. Dr Furness began her research career in 2003 investigating folate and B vitamin metabolism, methylation and DNA damage in relation to pregnancy health. Over the years her research expanded to include vitamin D, immune health and oxidative stress in relation to both male and female fertility. This research was conducted with the University of Adelaide, CSIRO human nutrition and The Women's and Children's Hospital in Adelaide, Australia. During this time, she witnessed a high success rate in the recurrent miscarriage and high-risk pregnancy clinics. She has published her work in peer reviewed journals and has won numerous awards for her research and conference presentations. In 2012 Dr Furness founded Your Genes & Nutrition and began working with integrative medical doctors and learning about functional medicine. She has since become a prominent thought leader in this field and lectured for the Australasian College of Nutritional and Environmental Medicine (ACNEM), is editor of the ACNEM Journal and on the editorial board for the Nutritional Medicine Journal. Dr Furness regularly lectures globally at conferences for health professionals on topics related to nutrigenomics and functional medicine. In her clinical practice, Dr Furness works with a range of patients helping them identify underlying triggers and root causes of their health concerns. Using a combined approach of genetics, biochemical markers, nutrition and lifestyle medicine she helps people take charge of their health and wellbeing. Guest websites and links: https://drdenisefurness.com.au Selection of our guest's publications: Jankovic-Karasoulos T, Furness DL, Leemaqz SY, Dekker GA, Grzeskowiak LE, Grieger JA, Andraweera PH, McCullough D, McAninch D, McCowan LM, Bianco-Miotto T, Roberts CT. Maternal folate, one-carbon metabolism and pregnancy outcomes. Matern Child Nutr. 2021 Jan;17(1):e13064. Kos BJP, Leemaqz SY, McCormack CD, Andraweera PH, Furness DL, Roberts CT, Dekker GA. The association of parental methylenetetrahydrofolate reductase polymorphisms ( MTHFR 677C > T and 1298A > C) and fetal loss: a case-control study in South Australia. J Matern Fetal Neonatal Med. 2020 Mar;33(5):752-757. McCormack CD, Leemaqz SY, Furness DL, Dekker GA, Roberts CT. Anti-Müllerian hormone levels in recurrent embryonic miscarriage patients are frequently abnormal, and may affect pregnancy outcomes. J Obstet Gynaecol. 2019 Jul;39(5):623-627. McCormack C, Leemaqz S, Furness D, Dekker G, Roberts C. Association between vitamin D status and hyperinsulinism. J Matern Fetal Neonatal Med. 2019 Dec;32(23):4005-4008. Furness DL, Yasin N, Dekker GA, Thompson SD, Roberts CT. Maternal red blood cell folate concentration at 10-12 weeks gestation and pregnancy outcome. J Matern Fetal Neonatal Med. 2012 Aug;25(8):1423-7.
Thomas G. Guilliams, PhD is an expert in a systems-biology based approach to dietary interventions, lifestyle medicine and nutritional and herbal supplements. This conversation shares his insights from extensive experience in dietary supplements that culminated in the publication of a foundational textbook, Supplementing Dietary Nutrients. We discus important themes such as how to contextualise the use and expectations of supplements alongside dietary and lifestyle changes, marketing vs. science, bioavailability, and issues around quality. Guest: Thomas G. Guilliams, PhD About our guest: Thomas G. Guilliams, PhD (Tom) earned his doctorate in molecular immunology from the Medical College of Wisconsin. For the past 28 years, he has spent his time investigating the mechanisms and actions of lifestyle and nutrient-based therapies and is an expert in the science and therapeutic uses of dietary supplements. Tom currently serves as an adjunct associate professor at the University of Wisconsin School of Pharmacy and was the VP of Science for Ortho Molecular Products for 24 years (he now serves them as a consultant). Over the past decade, he has written a series of teaching manuals (Road Maps) that teach and evaluate the principles and protocols that are fundamental to the functional and integrative medical communities. His publication The Role of Stress and the HPA Axis in Chronic Disease Management, now in its second edition, has become the standard for teaching this critical topic to healthcare professionals. He is the founder and director of the Point Institute, an independent research and publishing organization that facilitates the distribution of his many publications. A frequent guest-speaker, Dr. Guilliams provides straight-forward science-based training to a variety of healthcare disciplines in the use of lifestyle and non-pharmacological therapies. Tom is an avid outdoorsman with too many hobbies to list. He is blessed to live in the woodlands of Central Wisconsin with his family. Guest websites and links: https://www.pointinstitute.org Selection of our guest's publications: Guilliams, T. Supplementing Dietary Nutrients, Second Edition. The Point Institute. 2020. Guilliams, T. Bioavailability of Supplemental Dietary Nutrients: Challenges and Conundrums. The Point Institute. 2020. Guilliams TG, Weintraub J. Implementing Personalized Dietary Interventions for Immune-Mediated Inflammatory Diseases. Integr Med (Encinitas). 2023 Nov;22(5):18-26. Guilliams TG, Drake LE. Meal-Time Supplementation with Betaine HCl for Functional Hypochlorhydria: What is the Evidence? Integr Med (Encinitas). 2020 Feb;19(1):32-36.
Dr David Unwin started a grass-roots approach to reversing cardiometabolic disease, in particular type-2 diabetes, in his clinical practice that has resulted in the publication of clinical evidence documenting patient outcomes and spurred a global movement that is transforming people's lives. In this remarkable conversation he shares his story, insights from the work he is doing, and new concepts around ultra-processed food addiction. Guest: Dr. David Unwin About our guest: Dr David Unwin is an award-winning GP known for pioneering the low-carb approach in the UK. He is the Royal College of General Practitioners (RCGP) national champion for collaborative care and support planning in obesity and diabetes. He also won the NHS Innovator of the Year Award 2016 for his research into diet and lifestyle interventions. He has worked at Norwood Surgery in Southport since 1986 as a family doctor. To date, he has helped 141 patients achieve drug free, type 2 diabetes remission (achieving a remission rate of 51 per cent). Guest websites and links: https://phcuk.org/ https://phcuk.org/sugar/ https://courses.bslm.org.uk/product?catalog=1693826133zBxc8 Selection of our guest's publications: Unwin J, Delon C, Giæver H, Kennedy C, Painschab M, Sandin F, Poulsen CS, Wiss DA. Low carbohydrate and psychoeducational programs show promise for the treatment of ultra-processed food addiction: 12-month follow-up. Front Psychiatry. 2025 Apr 14;16:1556988. doi: 10.3389/fpsyt.2025.1556988. PMID: 40357512; PMCID: PMC12067479. Unwin D, Delon C, Unwin J, Tobin S, Taylor R. What predicts drug-free type 2 diabetes remission? Insights from an 8-year general practice service evaluation of a lower carbohydrate diet with weight loss. BMJ Nutr Prev Health. 2023 Jan 2;6(1):46-55. Unwin D, Unwin J, Crocombe D, Delon C, Guess N, Wong C. Renal function in patients following a low carbohydrate diet for type 2 diabetes: a review of the literature and analysis of routine clinical data from a primary care service over 7 years. Curr Opin Endocrinol Diabetes Obes. 2021 Oct 1;28(5):469-479. Brown A, McArdle P, Taplin J, Unwin D, Unwin J, Deakin T, Wheatley S, Murdoch C, Malhotra A, Mellor D. Dietary strategies for remission of type 2 diabetes: A narrative review. J Hum Nutr Diet. 2022 Feb;35(1):165-178. Unwin D, Khalid AA, Unwin J, Crocombe D, Delon C, Martyn K, Golubic R, Ray S. Insights from a general practice service evaluation supporting a lower carbohydrate diet in patients with type 2 diabetes mellitus and prediabetes: a secondary analysis of routine clinic data including HbA1c, weight and prescribing over 6 years. BMJ Nutr Prev Health. 2020 Nov 2;3(2):285-294. McAuliffe S, Unwin D, Bradfield J, Ray S, Martyn K. Bridging the gap between science-led research and evaluation of clinical practice: the role of service innovation audits and case studies. BMJ Nutr Prev Health. 2021 Feb 16;4(1):350-351.
Dr. Michelle Barrow is transforming personalised nutrition practice through rigorous academic training and the publication of research at the Centre for Nutrition Education & Lifestyle Management (CNELM), where she is Academic Team Director and Clinical Director. A key area of focus in her work is ' pathophysiological reasoning,' which builds on systems biology and functional medicine. Dr. Barrow share her personal story, her research, and why she is so passionate about building a better model for healthcare that is evidence-based and personalised with nutritional therapy and lifestyle medicine at its core. Guest: Dr. Michelle Barrow About our guest: Dr Michelle Barrow, DProf is the Academic Team Director and Clinical Director at CNELM. Her roles also include BSc (hons) Nutritional Science Programme Leader, Institution Link Tutor, Lecturer, and Research Supervisor. Michelle thoroughly enjoys supporting students to achieve their aspirations and goals. Her passion comes from overcoming her own health issues using nutrition. Michelle strives to develop the evidence base to support personalised nutrition practice through her academic work, research supervision, post-doctoral research, and publication. She completed a Doctorate in Professional Studies (DProf) in 2019, titled "Leading transformation in Personalised Nutrition Practice". Her doctoral research included the construction of clinical tools to enable the development of a new case-by-case evidence base for personalised nutrition practice in obesity management. Michelle continues to work on the development of robust translational bioinformatics tools, using pathophysiological reasoning and systems biology approaches, as they are key to achieving evidence based personalised nutrition practice. She is published in numerous scientific journals, including Autoimmunity Reviews, Nutrition Reviews and Current Research in Food and Nutrition. Michelle is a Registered Nutritional Therapist and was awarded fellow membership with the British Association of Nutrition and Lifestyle Medicine (BANT) in 2017 for outstanding contribution to the profession. Guest websites and links: https://www.researchgate.net/profile/Michelle-Barrow-2/research Selection of our guest's publications: Barrow M, Bell L, Bell C. Transforming personalized nutrition practice. Nutr Rev. 2020 Dec 1;78(12):1046-1051. Vázquez B, Barrow M, Neil J, Seidler K. Is there a role for nutritional advice during breastfeeding for infant colic relief? A mixed-method study. Heliyon. 2024 Dec 28;11(1):e41562. Crabtree D, Seidler K, Barrow M. Pathophysiological mechanisms of gut dysbiosis and food allergy and an investigation of probiotics as an intervention for atopic disease. Clin Nutr ESPEN. 2025 Feb;65:189-204. Quinones D, Barrow M, Seidler K. Investigating the Impact of Ashwagandha and Meditation on Stress Induced Obesogenic Eating Behaviours. J Am Nutr Assoc. 2025 Jan;44(1):68-88. Swallow J, Seidler K, Barrow M. The mechanistic role of curcumin on matrix metalloproteinases in osteoarthritis. Fitoterapia. 2024 Apr;174:105870.
Phytonutrients have been called the 'dark matter' of nutrition, a significant but often uncharacterised and poorly understood class of nutrients that have a profound impact on human health. In this remarkable interview, Dr. Deanna Minich dives into her specialist area, the relationship between phytonutrients, health and wellbeing. She discusses new research that is changing the way we think about plant foods, controversies such as diets that restrict plants, and weaves in several practical clinical takeaways that bridge the connections between food, biology, behaviour, environment, and spirit. Guest: Dr. Deanna Minich, MS, PhD, CNS About our guest: Deanna Minich, MS, PhD, CNS, Certified Functional Medicine Practitioner (IFMCP), is a nutrition scientist, international lecturer, teacher, and author, with over twenty years of experience in academia and in the food and dietary supplement industries. Throughout the years, she has been active as a functional medicine clinician in clinical trials and in her own practice (Food & Spirit™), which has now become oriented towards groups, workshops, and retreats. She is the author of seven consumer books on wellness topics, four book chapters, and over fifty scientific publications. Her academic background is in nutrition science, including a Master of Science (M.S.) degree in Human Nutrition and Dietetics from the University of Illinois at Chicago (1995) and a Doctorate (Ph.D.) in Medical Sciences (nutrition focus) from the University of Groningen in the Netherlands (1999). For a decade, she was part of the research team led by the "father of Functional Medicine," Dr. Jeffrey Bland, and has served on the Nutrition Advisory Board for The Institute of Functional Medicine, as well as on the Board of Directors for the American Nutrition Association. Since 2013, she has been part of the faculty for the Advanced Practice Module in Environmental Health offered by the Institute for Functional Medicine and has been teaching a graduate level course in metabolic detoxification at the University of Western States. Over the decades, she has taught thousands of nutrition classes for health coaches, fitness trainers, and healthcare professionals, including for programs offered by the Functional Medicine Coaching Academy, the Integrative and Functional Nutrition Academy, and the Institute for Integrative Nutrition. In conjunction with her academic degrees and extensive teaching experience at the university level, she is both a Fellow (FACN) and a Certified Nutrition Specialist (CNS) through the American College of Nutrition. She is Chief Science Officer at Symphony Natural Health, where she leads the medical advisory team, oversees scientific communication, and provide educational leadership for the company's plant-derived nutraceuticals. She is passionate about helping others to live well using therapeutic lifestyle changes that impact their physical, emotional, mental, and spiritual health. Guest websites and links: https://www.foodandspirit.com Selection of our guest's publications: Minich DM. A Review of the Science of Colorful, Plant-Based Food and Practical Strategies for "Eating the Rainbow". J Nutr Metab. 2019 Jun 2;2019:2125070. Petroski W, Minich DM. Is There Such a Thing as "Anti-Nutrients"? A Narrative Review of Perceived Problematic Plant Compounds. Nutrients. 2020 Sep 24;12(10):2929. Minich DM, Brown BI. A Review of Dietary (Phyto)Nutrients for Glutathione Support. Nutrients. 2019 Sep 3;11(9):2073. Bush CL, Blumberg JB, El-Sohemy A, Minich DM, Ordovás JM, Reed DG, Behm VAY. Toward the Definition of Personalized Nutrition: A Proposal by The American Nutrition Association. J Am Coll Nutr. 2020 Jan;39(1):5-15.
Dr. Hemilä became interested in the possible benefit of vitamin C (ascorbic acid) when exposed to conflicting opinions on its clinical efficacy. He has spent decades specialising in vitamin C research and, as a result, has addresses important issues such as the efficacy of vitamin C, sub-groups most likely to benefit, and dose-response relationship. Dr. Hemilä has also published several important papers that reveal methodological and analytical problems as well as bias in vitamin C research that, at least in part, explain why vitamin C has been sidelined in medicine and erroneously dismissed. In this informative interview he speaks to the history of vitamin C research for infection and its clinical implications. Guest: Dr. Harri Hemilä, MD, PhD About our guest: Dr. Harri Hemilä first studied biochemistry and received his PhD (biochemistry) in 1993. Thereafter he studied medicine and receive MD degree, and thereafter PhD (epidemiology) in 2006. His major scientific interest has been the effects of vitamin C on the common cold, and on infections in general. He has not done experimental work of his own in this field, but he has carried out several meta-analyses that have estimated the effects of vitamin C from studies published over half a century. He has also analyzed the effects of vitamin E on infections and on total mortality in the ATBC Study data set of 29,133 Finnish male smokers. Most recently he has carried out meta-analyses on the treatment effects of zinc lozenges on the duration of the common cold. Along with research, he is doing clinical work in the GP context. By the year 2021, he has 155 PubMed publications, 76 of which are focused on vitamin C, 28 on vitamin E, and 12 on zinc lozenges. Dr. Hemilä is Adjunct Professor at the Department of Public Health, University of Helsinki. Guest websites and links: https://www.researchgate.net/profile/Harri-Hemilae-2 Selection of our guest's publications: Hemilä H, Chalker E. Vitamin C for the common cold and pneumonia. Pol Arch Intern Med. 2025 Jan 30;135(1):16926. Hemilä H, Chalker E. Vitamin C reduces the severity of common colds: a meta-analysis. BMC Public Health. 2023 Dec 11;23(1):2468. Hemilä H, Chalker E. Bias against Vitamin C in Mainstream Medicine: Examples from Trials of Vitamin C for Infections. Life (Basel). 2022 Jan 3;12(1):62. Hemilä H, de Man AME. Vitamin C and COVID-19. Front Med (Lausanne). 2021 Jan 18;7:559811. Hemilä H. Vitamin C and Infections. Nutrients. 2017 Mar 29;9(4):339.
Dr. Yanuck provides a deep but practical understanding of how to approach complex immunological problems from an evidence-informed, hypothesis generating perspective that can provide a foundation for personalised clinical interventions. He explores the theme of the NLRP3 inflammasome, its intersection with autophagy and why this is relevant to many common immunological challenges including autoimmunity, metabolism, thyroid function, inflammation, T cell polarization and the capacity to clean up cells. Guest: Dr. Samuel Yanuck About our guest: Dr. Samuel Yanuck, DC, FACFN, FIAMA is an adjunct assistant professor in the Program on Integrative Medicine, in the Department of Physical Medicine and Rehabilitation at the University of North Carolina School of Medicine. With his wife, Cheryl Yanuck, MD, a psychiatrist, Dr. Yanuck runs the Yanuck Center for Life and Health, a functional medicine clinic in Chapel Hill, North Carolina. His practice is primarily focused on the care of patients with autoimmune disease, chronic infection, persistent inflammatory process, chronic GI disorders, or other immunologically involved challenges. Dr. Yanuck also provides online consultations for clinicians. Cogence Immunology is the creation of Dr. Yanuck the company's CEO and Director of Education. Dr. Yanuck began studying immunology in 2001, after he observed that focusing on specific patterns in immune function could profoundly influence the outcomes of challenging cases. The more he learned, the better the outcomes became. Cogence® Immunology reflects Dr. Yanuck's more than two decades of immunology study and clinical experience. Dr. Yanuck has published a number of research papers in peer-reviewed medical journals on topics related to functional immunology, including neurological, inflammatory, infectious and autoimmune disorders as well as the cancer immune microenvironment. Guest websites and links: https://cogenceimmunology.com Selection of our guest's publications: Yanuck SF. Failed Induction of the T H 1 System in T H 2 Dominant Patients: The Cancer-Permissive Immune Macroenvironment. Integr Med (Encinitas). 2024 May;23(2):24-35. Yanuck SF, Pizzorno J, Messier H, Fitzgerald KN. Evidence Supporting a Phased Immuno-physiological Approach to COVID-19 From Prevention Through Recovery. Integr Med (Encinitas). 2020;19(Suppl 1):8-35. Yanuck SF. Microglial Phagocytosis of Neurons: Diminishing Neuronal Loss in Traumatic, Infectious, Inflammatory, and Autoimmune CNS Disorders. Front Psychiatry. 2019 Oct 3;10:712.
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