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Published by Serotonin
The world is changing at an accelerating pace—Endgame is here to make sense of it. Hosted by Amanda Cassatt, founder of Serotonin, this podcast brings you conversations with the visionaries driving breakthrough technologies and shaping the future. Join Amanda as she unpacks the trends, innovations, and paradigm shifts defining our time. Where is this all going? Let’s figure it out together. Subscribe now on Apple Podcasts, Spotify, YouTube, and wherever you listen.
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Malcolm and Simone Collins became known as prominent voices in the pronatalist movement. But today, much of their work is focused on a different question: what happens to humans, culture, education, and future generations as artificial intelligence transforms society? In this episode of Endgame, Amanda Cassatt sits down with Malcolm and Simone to explore how AI is reshaping internet culture, why they believe the next major culture war is forming around artificial intelligence, and what it means to raise children in a world where machines may outperform humans at increasingly general tasks. They discuss how they are preparing their own children for a post-AI economy, why specialization may become more valuable than being a generalist, and whether humans will remain economically necessary as AI agents become more capable. The conversation also explores the evolution of internet subcultures, the rise of AI-generated media, effective altruism and “stellar humanism,” genetic technology, pronatalism, demographic decline, and the question at the center of it all: what kind of people and what kind of civilization will thrive in the future? Malcolm and Simone also discuss their work with rfab.ai and how they think AI tools can expand individual creative and technological capabilities. Timestamps 00:10 — Introduction 04:46 — From Tech and VC to Pronatalism 09:04 — Genetic Screening and the Origins of Their Movement 12:55 — How Internet Media Creates Celebrity 15:30 — Why Pronatalism Went Mainstream 20:10 — How Internet Subcultures Become Mainstream Culture 25:30 — Is AI the Next Culture War? 28:21 — Could AI Art Become Bigger Than Memes? 32:26 — Effective Altruism vs. Stellar Humanism 39:06 — Are Humans Being Replaced by AI? 43:24 — What Happens When Humans Lose Their Economic Advantage? 45:23 — Raising Children in the Age of AI 50:01 — Teaching Kids How to Use Technology Safely 52:29 — Should AI Uncertainty Change the Decision to Have Kids? 57:16 — Can Pronatalism Reverse Falling Birth Rates? 58:42 — Building Culture for a Post-AI Future 1:02:57 — Their Alternative to Modern Dating 1:03:00 — Building rfab.ai and an AI-Native Community Stay Connected https://x.com/amandacassatt https://x.com/serotonin_hq Apple Podcasts & Spotify https://open.spotify.com/show/6iSvbKOJWoEPiAoGmiulkd https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440 Follow Simone & Malcolm Collins https://www.instagram.com/simonehcollins/?hl=en
Santiago R. Santos of Inversion was investing in DeFi before “DeFi” was even a widely used term. As a former partner at ParaFi and an early investor in projects including Aave, Arbitrum, and Polymarket, he watched Ethereum evolve from an experimental smart contract platform into the foundation of a massive onchain economy. But the growth of crypto has also changed his investment thesis. In this episode of Endgame, Amanda Cassatt and Santiago R. Santos examine whether Ethereum can succeed while ETH captures less of the value created on top of it, why he expresses his long-term Ethereum thesis through Robinhood stock, and why he believes crypto is increasingly becoming a distribution race. They also explore what Santiago learned from betting on Western Union over Solana, why adding stablecoins to legacy businesses is harder than it looks, whether AI agents actually need crypto-native money, and how autonomous agents could choose between blockchains without the tribal loyalties humans bring to crypto. Finally, they discuss the evolution of prediction markets, why Santiago believes market integrity matters as platforms like Polymarket grow, and how prediction markets and 24/7 crypto markets could evolve beyond speculation into tools for insurance, hedging, and real-time risk management. Timestamps 00:00 - Can Ethereum Win While ETH Loses? 00:36 - Investing in Aave Before DeFi Summer 05:06 - What Changed Santi’s Ethereum Thesis 10:30 - Can Ethereum Win While ETH Loses? 11:40 - Hyperliquid vs. Ethereum 13:44 - Is ETH Properly Valued Today? 18:16 - Where Crypto Networks Actually Capture Value 21:10 - Why Santiago R. Santos Owns Robinhood Instead of ETH 24:02 - Crypto Is Becoming a Distribution Race 27:37 - Why Santiago R. Santos Bet on Western Union Over Solana 30:30 - Why Adding Crypto to Legacy Businesses Is Hard 35:47 - Do AI Agents Actually Need Stablecoins? 40:42 - How AI Agents Will Choose Blockchains 45:27 - Why 24/7 Crypto Markets Matter 47:59 - AI Agents, Prediction Markets and Insurance 51:26 - Does Polymarket Need Insider Trading Rules? 59:15 - Prediction Markets Beyond Speculation 🎧Stay Connected https://x.com/amandacassatt https://x.com/serotonin_hq Apple Podcasts & Spotify https://open.spotify.com/show/6iSvbKOJWoEPiAoGmiulkd https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440 Follow Santiago R. Santos https://x.com/santiagoroel?lang=en https://mc.linkedin.com/in/santiago-rs
What if we could select the optimal genetic traits for our children? In this episode of Endgame, Amanda Cassatt sits down with bioethicist and philosopher Jonathan Anomaly to explore the cutting edge of reproductive biotechnology. They dismantle the social and political taboos surrounding genetic curation, tracing everything from the uncomfortable reality of cognitive capacities and human success to the macro ethical implications of advanced embryo selection. Jonathan argues why denying genetic influence is an intellectually dangerous myth and details how decentralized biotechnology will soon allow humanity to shift from being passive victims of natural selection to becoming its active architects. This is a raw, unfiltered conversation about modern inequality, human cognitive potential, and the existential risks of trying to optimize our own species. Timestamps 00:00 Intro 04:59 What Does “Eugenics” Mean Today? 09:13 IQ, Personality & Cognitive Diversity 15:47 Are Intelligence and Personality Genetic? 18:11 Nature vs. Nurture: How Much Is Genetic? 20:35 Is IQ Really 70% Heritable? 22:50 Why IQ Matters for Embryo Selection 27:21 How Much Can Embryo IQ Actually Differ? 29:43 The Risks of Maximizing Intelligence 32:08 Should We Genetically “Optimize” Humans? 34:26 How Genetic Selection Could Change Dating 36:47 Sperm Donors, Genetics & the Future of Reproduction 39:07 Do Polygenic Embryo Scores Actually Work? 41:24 How Herasight Predicts Genetic Traits 43:46 The Genetic Data Gap Across Ancestries 46:06 IVG, Artificial Wombs & the Future of IVF 48:26 When Could “Babies From a Blood Draw” Arrive? 50:23 CRISPR, Gene Editing & Its Biggest Risks 52:52 Are We Going Too Far With Human Genetics? 55:07 Should Parents Prevent Genetic Disabilities? 56:29 The Ethics of Selecting Against Disease 57:45 The Hidden Risks of Genetic Selection 58:08 Should Genetics Be Left to the Free Market? 58:28 The Coming “Polygenic Revolution” 59:00 Can We Make Human Nature Better? Stay Connected Amanda on X: https://x.com/amandacassatt Serotonin on X: https://x.com/serotonin_hq Spotify https://open.spotify.com/episode/45B9szUxVXEwfCDA6uRxwq?si=HT9XXqF9Q2CcM9hfLbmkVg Endgame on Apple Podcasts https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440 Follow Jonathan Anomaly https://x.com/JonathanAnomaly Don’t forget to subscribe!
Corporate metaverses failed the moment big tech tried to turn human connection into a closed retail space. In this episode of Endgame, Second Life creator Philip Rosedale joins Amanda Cassatt to explain why corporate giants spent $80 billion and still couldn't build a functional virtual world. Moving far beyond the surface-level hype of Silicon Valley, Philip exposes how algorithmic feeds and centralized interfaces are stripping away genuine human sovereignty, leaving us with a cheap illusion of agency. They dive deep into the high-stakes ethics of emerging technology, explaining why corporate LLMs risk breeding digital demons if we continue to treat artificial entities as enslaved tools for profit rather than digital offspring. Discover why true digital freedom requires localized artificial life and persistent pseudonymity rather than surveillance state biometric scans. Timestamp 0:00 – Welcome 3:01 – What did Second Life know 20 years ago that Meta still doesn't? 5:07 – The COVID-era logic that convinced everyone we'd all end up in the metaverse 7:17 – Why virtual worlds still can't replicate meeting a stranger in person 9:30 – Who actually stays in Second Life: repressive regimes and long-term escape 11:13 – Is staying in a virtual world for life a good thing? 13:19 – Do shooter video games actually teach transferable skills? 15:13 – Why women used Second Life more effectively than men 17:13 – Roblox, Minecraft, and the ethics of monetizing kids 19:13 – Why Second Life deliberately stores nothing about you: the case for pseudonymity 21:27 – Did Second Life become what Rosedale actually wanted? 23:24 – The night the community blew up his own nightclub 25:16 – Is technology pulling people together or tearing them apart? 27:42 – From Wikipedia optimism to "big tech has done nothing but harm" 30:03 – Are AI models conscious? Defining consciousness itself 32:21 – Marc Andreessen says there's no path to AI consciousness — does Rosedale agree? 34:45 – Will machines start demanding rights? 39:25 – "Awakening the Angels": should AI be unstoppable and unowned? 41:50 – "Machines are our children": raising AI as independent offspring 44:12 – What he's building at New Theory, beyond LLMs 46:23 – Artificial life, cellular automata, and the other path to AGI 48:41 – Fusing atoms and bits — and why crypto's obsession with "sovereignty" might be an illusion 50:15 – Closing case for nuance over Silicon Valley's binary thinking Stay Connected Amanda on X: https://x.com/amandacassatt Serotonin on X: https://x.com/serotonin_hq Spotify https://open.spotify.com/episode/45B9szUxVXEwfCDA6uRxwq?si=HT9XXqF9Q2CcM9hfLbmkVg Endgame on Apple Podcasts https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440 Follow Philip Rosadale https://x.com/philiprosedale https://www.linkedin.com/in/philiprosedale
As chief cryptographer of Sui and Mysten Labs, Kostas Chalkias helped design a blockchain built on more than 100 published cryptography papers and an object-based architecture fast enough to let AI agents chain dozens of transactions into a single intent, without skipping the security research most "fast chains" leave out entirely. In this episode of Endgame, Amanda Cassatt sits down with Kostas to break down why validators froze $163 million after the Cetus hack, why post-quantum migration can't wait for a crisis to force it, and why he thinks cryptographers now have exactly one place left to do their best work. But the most unexpected part isn't the tech; it's the path. Chalkias was lecturing cryptography at universities in Dubai before spending three years building Facebook's ill-fated Libra project. He walked away from Meta because, in his words, it was too slow for how fast cryptography actually moves. Now he's chief cryptographer at one of the most talked-about L1s in the space. Timestamp 0:00 – Is the quantum threat to Bitcoin and Ethereum real, or Sui's marketing wedge? 0:42 – Why every chain needs to start quantum migration now 2:32 – Why isn't a single top-40 blockchain quantum-safe yet? 7:52 – Why leave Facebook's Libra project to build another L1? 9:05 – Bitcoin, Ethereum, Solana already won so why build Sui? 21:06 – Why has Sui gone down more than once? 24:33 – The Cetus hack: why validators froze $163M 27:01 – What can only be built on Sui's object-based architecture? 30:14 – Is Sui's confidential-transactions push just Tornado Cash with extra steps? Stay Connected Amanda on X: https://x.com/amandacassatt Serotonin on X: https://x.com/serotonin_hq Spotify https://open.spotify.com/episode/45B9szUxVXEwfCDA6uRxwq?si=HT9XXqF9Q2CcM9hfLbmkVg Endgame on Apple Podcasts https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440 Follow Kostas Chalkias https://www.linkedin.com/in/chalkiaskostas https://x.com/kostascrypto?lang=en
Diogo Mónica co-founded Anchorage Digital, the first federally chartered crypto bank in the US, and now argues for a position most of Silicon Valley won't say out loud: America should be building closed AI, not open source. In this episode of Endgame, Amanda Cassatt sits down with Diogo, Co-Founder of Anchorage Digital and General Partner at Haun Ventures, to break down why he thinks open-sourcing AI just hands China a free ride, why he calls AI "the ultimate weapon," and why he considers defending US AI intellectual property "perfectly legitimate." They also discuss his board seat at Erebor, Palmer Luckey's new bank for crypto, AI, and defense companies; why stablecoins bridge crypto anarchism and financial regulation; and why he calls building in crypto an act of American patriotism. Timestamp 0:56 – Kicking off with Katie Haun and Haun Ventures 2:13 – Reconciling his crypto-anarchist roots with his own philosophy 3:15 – Founding a regulated bank: Anchorage Digital 4:18 – Stablecoins: centralized control on decentralized rails 5:26 – Would a crypto anarchist say regulation just protects incumbents? 6:38 – Is building in crypto an act of American patriotism? 8:11 – Can crypto be "American-made" if it was born borderless? 13:25 – Introducing Palmer Luckey and the US-China AI/crypto landscape 14:21 – Is America on the right side of technology history? 15:39 – Why he believes America should build closed AI, not open source 16:31 – Does intellectual property even make sense in the AI age? 17:55 – Is the "China competition" narrative a political red herring? 18:18 – AI as "the ultimate weapon" and the end of mutually assured destruction 19:46 – Turning the protectionism question back on China (Google, Gmail, Twitter) 20:21 – Building Erebor: Palmer Luckey's bank for crypto, AI, and defense 22:55 – Toward a left-wing and right-wing version of every business? 24:14 – Crypto's real legacy: financial education for an entire generation Stay Connected ● Amanda on X: https://x.com/amandacassatt ● Serotonin on X: https://x.com/serotonin_hq ● Spotify https://open.spotify.com/episode/45B9szUxVXEwfCDA6uRxwq?si=HT9XXqF9Q2CcM9hfLbmkVg Endgame on Apple Podcasts https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440 Follow Diogo Monica https://www.linkedin.com/in/diogomonica https://x.com/diogomonica?lang=en Don’t forget to subscribe! #EndGame #AI #crypto #bitcoin #fintech
Robinhood is evolving far beyond commission-free trading. In this episode of Endgame, Amanda Cassatt sits down with Johann Kerbrat, SVP & GM of Robinhood Crypto, for an in-depth conversation about how Robinhood is using blockchain, AI, and tokenization to reshape investing. Johann explains why Robinhood built its own Layer 2 on Ethereum, how tokenized stocks work in Europe, why Robinhood believes financial markets should operate 24/7, and how AI is changing the future of investing. They also discuss crypto regulation, DeFi, prediction markets, Ethereum vs. Solana, Robinhood Wallet, self-custody, and Robinhood’s long-term vision for bringing traditional financial assets onchain. If you’re interested in crypto, fintech, investing, AI, or the future of financial markets, this conversation offers a rare look inside one of the world’s largest retail investing platforms. In this episode: • Why Robinhood built on Ethereum and Arbitrum • Tokenized stocks explained (EU vs. US) • The future of on-chain ownership • Robinhood’s vision for 24/7 financial markets • AI’s role inside Robinhood • How AI agents could transform investing • DeFi made simple • Robinhood Wallet and self-custody • Ethereum vs. Solana • Prediction markets vs. gambling • Robinhood’s acquisition of WonderFi • The future of global investing Timestamps: 00:00 Introduction 00:20 What Makes Robinhood Different 02:10 Crypto Fees and Accessibility 04:06 Crypto’s Role at Robinhood 05:06 Tokenized Stocks Explained 09:38 What Investors Actually Own 10:57 Putting Real Stocks Onchain 12:31 The Case for 24/7 Markets 15:48 Why Robinhood Chose Ethereum 18:12 KYC and Decentralization 20:12 Are L2s Good for Ethereum? 21:27 Ethereum vs. Solana 22:45 How Robinhood Uses AI 24:22 AI, DeFi and WonderFi 25:32 Trading vs. Gambling 29:39 What’s Next for Robinhood? Stay Connected Amanda on X: https://x.com/amandacassatt Serotonin on X: https://x.com/serotonin_hq https://open.spotify.com/episode/45B9szUxVXEwfCDA6uRxwq?si=HT9XXqF9Q2CcM9hfLbmkVg Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440 Follow Johann Kerbrat https://x.com/JohannKerbrat?lang=en https://www.linkedin.com/in/johann-kerbrat #EndGame #Robinhood #Tokenization #DeFi #Web3
In this episode of Endgame, the roles are reversed. Timour Kosters takes the mic to interview Amanda Cassatt. Together they explore why technology can both expand and limit freedom, how smartphones and algorithms shape our choices, why LLMs may homogenize culture and creativity, and what crypto still offers as a hedge against centralized control. They also discuss Bitcoin, Ethereum, stablecoins, financial privacy, AI’s impact on society, TikTok, purpose, meaning, and why Amanda rejects a traditional “endgame” altogether. Timestamp 00:00 — Turning the tables 02:15 — The Ethereum years: Making the complex legible to the world 06:40 — The iPhone Trap: Why you don’t own your digital life 11:55 — Root Access: Why we are living in a state of "Digital Serfdom" 16:30 — LLMs vs. Human Thought: The homogenization of everything 21:10 — Why Bitcoin and Ethereum are bulwarks against authoritarianism 25:45 — The "Digital Marshall Plan": Stablecoins and the future of sovereignty 30:15 — Edge City and the birth of the Network State 35:50 — "If you have a goal, you're co-optable": The philosophy of agency 42:20 — Infinite vs. Finite Games: Who is writing your menu? 48:10 — Strengthening from the inside vs. regulating from the outside 49:58 — The story of the rising water: Breaking the frame of San Francisco Stay Connected: Subscribe to Endgame: https://www.youtube.com/@endgamepodcast Amanda on X: https://x.com/amandacassatt Serotonin on X: https://x.com/serotonin_hq Austin on X: http://x.com/Austin_Federa DoubleZero on X: https://x.com/doublezero Links to Follow: Endgame on Spotify: https://open.spotify.com/episode/45B9szUxVXEwfCDA6uRxwq?si=HT9XXqF9Q2CcM9hfLbmkVg Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440
How Swift works is one of the most misunderstood topics in crypto payments. Tom Zschach spent six years as Chief Innovation Officer at Swift, and he has unique insights to share. In this episode: Why stablecoins aren’t replacing Swift; they’re connecting to it Why Tom called Ripple a fax machine and stands by it Why a token isn’t money and what that means for settlement Why faster and cheaper isn’t the real prize- certainty is What it actually takes to move $50 million into Singapore when there’s no alternative
Adam Back invented the proof-of-work system that became Bitcoin's foundation. The New York Times says he's Satoshi Nakamoto. He says he isn't, but he was the first person Satoshi ever emailed. Every major publication is asking whether quantum computing will break Bitcoin. The consensus is nervous. Adam Back, the man who built Bitcoin's cryptographic foundation, is not. In this conversation, he explains why none of the quantum computers that exist today can perform a useful calculation, why you shouldn't expect a real threat before 2035 at the earliest, and why the institutions buying Bitcoin through BlackRock ETFs changed themselves. Not Bitcoin. They also get into the real state of building on Bitcoin, why Lightning Network channel numbers are shrinking is actually fine, how $2 billion in Mexican promissory notes ended up on a Bitcoin layer 2, and what a lifelong cypherpunk actually thinks about AI. Also in this episode - Why Lightning Network channel numbers are shrinking (and why that's fine) - How $2 billion in Mexican promissory notes ended up on a Bitcoin layer 2 - What a lifelong cypherpunk actually thinks about AI Timestamps: 0:00 Intro 0:30 Is Adam Back Satoshi? 1:37 Does the speculation bother him? 1:53 First contact: Satoshi reached out to Adam 2:53 Weirdest thing about being a Satoshi suspect 3:21 Hashcash and the CipherPunk mailing list 4:28 Why proof of work was the breakthrough 4:58 CipherPunk identity vs. BlackRock adoption 6:02 How he reconciles crypto anarchism with institutions 8:01 Are institutions changing Bitcoin or vice versa? 9:25 The case against institutional Bitcoin 10:19 Paper Bitcoin and synthetic derivatives 14:04 Why governments are buying gold, not Bitcoin 16:41 Has "build on Bitcoin" failed? 19:32 Lightning compression isn't a demand signal 19:57 Stablecoins and RWAs on Bitcoin layer 2 21:20 Why Mexican promissory notes ended up on Liquid 22:03 Adam's stance on quantum panic 23:33 The timeline skepticism 26:45 The danger of rushing a quantum solution 28:18 The security budget problem 31:13 What does a CipherPunk think of AI? Stay Connected Subscribe to Endgame: https://www.youtube.com/@endgamepodcast Amanda on X: https://x.com/amandacassatt Serotonin on X: https://x.com/serotonin_hq Links to Follow: Endgame on Spotify: https://open.spotify.com/episode/45B9szUxVXEwfCDA6uRxwq?si=HT9XXqF9Q2CcM9hfLbmkVg Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440 Follow Adam Back https://x.com/adam3us?lang=en
Cultural theorist and essayist Toby Shorin joins Amanda Cassatt to explore one of the most urgent questions of the AI era: What happens to the human body and human meaning when thinking itself becomes commodified? Drawing on his essay “Body Futurism,” Toby argues that we’re witnessing a massive embodied turn in culture, from peptides and biohacking to looks-maxing and sports investment. But the real question isn’t just why people are obsessing over their bodies; it’s whether that obsession represents liberation or a new form of algorithmic hijacking. In this episode, they discuss: - Bryan Johnson’s “don’t die” philosophy and why it’s rooted in fear, not vision - The difference between a protocol and a practice, and its political consequences - Who actually benefits from the loneliness epidemic narrative - What the “AI mind virus” looks like from inside the Bay Area - Why poetry might be the only genuine escape from the optimization loop If you’re interested in the intersection of AI, culture, embodiment, and meaning, this conversation is not to be missed. Timestamps: 0:00 Introduction 2:44 Why everyone is obsessed with their body right now 7:08 The philosophy behind biohacking and morphological freedom 10:42 Why "don't die" is actually a fear-based philosophy 13:27 What AI really threatens it's not your job 14:50 AI mastered chess. Chess adoption only grew. 18:05 Why PE firms are buying sports teams 20:41 Body as asset vs. body as practice 26:24 What is a narrative subsidy? 28:44 Who actually benefits from the loneliness epidemic 29:20 We forgot how to do the dance 31:52 Did Andrew Huberman invent seeing light in the morning? 32:44 How insurance culture took over everyday life 36:45 Two ways out of the optimization loop 38:00 The poetic way of seeing 40:29 Toby reads a poem he wrote this morning 42:09 The William Carlos Williams connection Stay Connected Subscribe to Endgame ➡️ https://www.youtube.com/@endgamepodcast Amanda on X: https://x.com/amandacassatt Serotonin on X: https://x.com/serotonin_hq Links to Follow: Endgame on Spotify: https://open.spotify.com/episode/45B9szUxVXEwfCDA6uRxwq?si=HT9XXqF9Q2CcM9hfLbmkVg Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440 Follow Toby Shorin https://www.instagram.com/tobyshorin/ https://www.linkedin.com/in/tobyshorin
Your identity, your assets, your privacy, do you actually own any of it online? Binji Pande from the Ethereum Foundation says no. And he's spent his career trying to change that. In this episode, Amanda sits down with Binji to explore why crypto is really about redesigning human incentives, what digital rights actually mean, and what it would take to build a world where freedom online isn't a privilege. Timestamps: 00:00 Introduction 03:21 How Binji got into crypto 05:17 If you can program money, you can change the world 09:53 Moloch, prisoner's dilemmas & why the system isn't evil, just indifferent 13:48 From Northwestern to Coinbase: breaking into crypto without a CS degree 15:12 The Ethereum tattoo and what it really means 18:23 Hardware. Software. Trustware. 20:05 How do you know if Ethereum is actually decentralized? 26:29 Ethereum's communication challenge 31:41 Digital rights: you can lock your bathroom door, why not online? 37:16 Privacy as dignity: data breaches, ZK, and the next frontier 43:19 CROPS: what the Ethereum Foundation actually stands for 44:44 Ethereum's roadmap: Is it shipping fast enough? 45:04 Canton, Tempo, competing chains, should Ethereum be worried? 47:00 The world worth building Stay Connected Subscribe to Endgame: https://www.youtube.com/@endgamepodcast Amanda on X: https://x.com/amandacassatt Serotonin on X: https://x.com/serotonin_hq Links to Follow: Endgame on Spotify: https://open.spotify.com/episode/45B9szUxVXEwfCDA6uRxwq?si=HT9XXqF9Q2CcM9hfLbmkVg Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440 Follow Binji https://www.linkedin.com/in/binjix23/ @binji_x
Everyone in crypto is chasing TPS Eunice Giarta thinks that's the wrong race entirely As co-founder of Monad Foundation, she spent four years building what she calls the Ethereum of high-performance blockchains a chain with validators on six continents, in 30 countries and 58 cities, that doesn't sacrifice decentralization for speed. In this episode of Endgame, Amanda Cassatt sits down with Eunice to break down what actually makes a blockchain worth building on in 2026, what the real killer use case for Monad looks like, and why bear markets build better products than bull markets. But the most unexpected part isn't the tech it's the path. Eunice went from Merrill Lynch to Shutterstock to a pastry kitchen at Jean-Georges in New York. A Pi Day pandemic layoff sent her down the crypto rabbit hole. Four years later, she co-founded one of the most talked-about L1s in the space. Timestamps: 0:00 Why there's no solid high-performance chain yet 2:30 Monad's 200 validators across 6 continents 5:30 Placing Monad on the decentralization spectrum 9:00 Why TPS is a misleading metric 12:00 The real use case: on-chain order books 15:30 How to measure real demand vs. incentive-driven usage 19:30 What AI agents would use Monad for 22:00 RWAs and institutional adoption 24:00 Monad's token launch and the bear market 27:00 From trading analyst to pastry chef to blockchain co-founder 31:30 Favorite macaron: chocolate miso from Pierre Hermé Stay Connected Subscribe to Endgame https://www.youtube.com/@endgamepodcast Amanda on X: https://x.com/amandacassatt Serotonin on X: https://x.com/serotonin_hq Links to Follow: Endgame on Spotify: https://open.spotify.com/episode/45B9szUxVXEwfCDA6uRxwq?si=HT9XXqF9Q2CcM9hfLbmkVg Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440 Follow Eunice Giarta https://www.linkedin.com/in/eunicegiarta https://x.com/0x_eunice?lang=en
“A lot of users don’t need a bank. What they need is a wallet.” In this episode of Endgame, Amanda Cassatt sits down with Richard Teng, CEO of Binance, for a conversation about what crypto actually became and whether that’s the right thing. Richard spent three decades in traditional finance, including the Central Bank of Singapore, before joining Binance in 2021. He doesn’t argue like a convert. He argues like someone who watched the old system fail for thirty years and decided the new one had to work differently. They start at the founding question: is crypto self-sovereign freedom tech or licensed infrastructure run by a handful of platforms? Richard’s answer is that the frame is wrong. Centralized exchanges aren’t a betrayal of the movement. They’re the interface the movement needs to reach the 1.4 billion people the financial system never bothered to serve. From there they move through Binance’s regulatory strategy in markets like Dubai, why the Genius Act sent stablecoin volume past Visa in under a year, and why regulatory clarity is the unlock for institutional capital, not just compliance overhead. Amanda pushes on financialization risk, tokenization of ownership, and whether crypto has run out of native narrative. Richard’s case for the SAFU fund, recovering assets sent to wrong chains, and what a financial super app means in frontier markets is the clearest argument for why centralization isn’t just commercially convenient but structurally necessary for the thing to work at all. Timestamps: 00:00 - Is crypto still freedom tech or licensed infra? 00:55 - 1.4 billion unbanked: why the system fails them 03:00 - Why 65% quit after their first onchain transaction 05:04 - What a bank actually does and what replaces it 07:30 - Binance as a financial super app for the excluded 09:30 - Binance does more for inclusion than governments 11:02 - China, protectionism and why countries need Binance 13:52 - The Dubai story: building a crypto hub from scratch 17:09 - Regulation as a moat vs regulation as a product 19:32 - The Genius Act and the stablecoin explosion 21:37 - Is compliance becoming incumbent protection? 24:39 - Binance's approach to the US market 26:29 - AI + Blockchain will rebuild every industry 28:42 - Will AI suck all trading value to the biggest firm? 33:11 - Binance AI Pro: what it actually does 36:46 - Crypto out of ideas? RWAs and the next narrative 39:14 - Why 24/7 trading changes everything 41:38 - Invisible crypto and the abstraction risk 45:58 - Hyperliquid vs Binance: who wins? 48:47 - Where does Binance's growth actually come from? 50:00 - The future: wallets replace banks 52:16 - The SAFU fund: $1B to protect users 54:23 - Crypto's real legacy: financial education 56:00 - Do banks really create money from a spreadsheet? Stay Connected Subscribe to Endgame: https://www.youtube.com/@endgamepodcast Amanda on X: https://x.com/amandacassatt Serotonin on X: https://x.com/serotonin_hq Links to Follow: Endgame on Spotify: https://open.spotify.com/episode/45B9szUxVXEwfCDA6uRxwq?si=HT9XXqF9Q2CcM9hfLbmkVg Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440 Follow Richard https://www.instagram.com/tengrich/ https://x.com/_RichardTeng
“The block explorer is your x-ray machine. Open it up, and you find rooms full of people.” In this episode of Endgame, Amanda Cassatt sits down with Austin Federa, former Head of Strategy at Solana and co-founder of DoubleZero, for a rare, candid conversation shaped by shared history on opposite sides of the Ethereum–Solana divide. They unpack the real meaning of decentralization: is it a philosophy, a design choice, or just branding? The discussion moves from the Drift hack—revealing how a months-long social engineering attack exposed crypto’s underlying security culture—to broader questions about trust, control, and the human systems beneath supposedly autonomous technology. Along the way, they explore financial nihilism, the psychological impact of the internet on risk-taking, and whether blockchains should stand for anything beyond speed and efficiency. What happens to values like openness and censorship resistance once real money enters the system? And who carries the ideology when institutions drift from it? Timestamps: 00:00 Crypto values and philosophy 03:07 Speed and the evolution of blockchain design 06:05 Decentralization vs. centralization 08:58 Solana’s practical approach 11:48 FTX and Solana’s resilience 15:03 The role of decentralization in finance 17:58 Meme coins and perceived value 20:58 Financial nihilism and Gen Z 30:15 The psychology of comparison online 34:34 Roots of financial nihilism 37:41 What money actually is 41:21 The Drift hack and crypto security culture 53:00 Building the future: DoubleZero Stay Connected: Subscribe to Endgame: https://www.youtube.com/@endgamepodcast Amanda on X: https://x.com/amandacassatt Serotonin on X: https://x.com/serotonin_hq Austin on X: http://x.com/Austin_Federa DoubleZero on X: https://x.com/doublezero Links to Follow: Endgame on Spotify: https://open.spotify.com/episode/45B9szUxVXEwfCDA6uRxwq?si=HT9XXqF9Q2CcM9hfLbmkVg Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440
In this episode of Endgame , Amanda Cassatt cuts through the AI hype to explore what happens when creation becomes free. The result isn’t less competition—it’s more noise. She unpacks a web flooded with AI content, misaligned platforms, and the rising value of curation, taste, and real skill. From the future of digital work to the surprising role of crypto—where AI agents, stablecoins, and frictionless UX may finally unlock DeFi—this conversation dives into the paradox of abundance and why judgment matters more than ever. Timestamps: 00:00 Introduction 02:21 What People Get Wrong About AI Right Now 04:36 Running to Stand Still: Skills and AI 08:27 AI's Sybil Attack on Content and Platforms 12:29 The Water Line Rising: Content Overload and Curation 21:08 Finding Nutritious Content in a Sea of AI-Generated Material 25:48 New Opportunities in Content Curation and Skill Sets 26:36 AI and Crypto: Future Intersections 33:14 Quantum Computing Risks and Opportunities 36:07 The Fintechization of Crypto and Narrative Shifts 38:01 Inextricable Values in Technology Stay Connected: Subscribe to Endgame: https://www.youtube.com/@endgamepodcast Amanda on X: https://x.com/amandacassatt Serotonin on X: https://x.com/serotonin_hq Links to Follow: Endgame on Spotify: https://open.spotify.com/episode/45B9szUxVXEwfCDA6uRxwq?si=HT9XXqF9Q2CcM9hfLbmkVg Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440
“The scammy elements of crypto are turning people off—and that’s something we need to fix.” In this episode of Endgame, Amanda Cassatt sits down with Yat Siu, co-founder of Animoca Brands, to unpack crypto’s evolution—from idealism to hype cycles—and what comes next. They explore AI agents, the open metaverse, and who actually benefits as technology scales. Yat argues blockchain was built for a future of billions of AI agents—and we’re closer than we think. The conversation also dives into creativity, education, and what it means to stay human in an increasingly automated world. At its core, this episode asks: who owns the system—and is the future being built one worth living in? Stay Connected: Yat Siu on X: https://x.com/ysiu Subscribe to Endgame: https://www.youtube.com/@endgamepodcast Amanda on X: https://x.com/amandacassatt Serotonin on X: https://x.com/serotonin_hq Links to Follow: Endgame on Spotify: https://open.spotify.com/episode/45B9szUxVXEwfCDA6uRxwq?si=HT9XXqF9Q2CcM9hfLbmkVg Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440 Substack: https://substack.com/@UCInZsV3L1nDGoFjxoNUnPQQ
Most of the people running the world are not evil masterminds; they are sincere operators trapped in an “epistemic maze.” In this episode of Endgame, Amanda Cassatt sits down with Curtis Yarvin to explore why the rules-based international order was always fragile and how elite decision-makers operate on unexamined assumptions. They unpack Yarvin’s “interchangeable baby theory,” the 20th-century belief that human outcomes are largely interchangeable, and how this flawed idea shaped policy without ever being questioned. The conversation shifts to modern finance, where deposit insurance, bailouts, and informal guarantees create a tower of promises barely anchored in reality. From there, they tackle AI, arguing that machines could make most humans economically useless unless society redesigns work, introducing artificial constraints so humans retain meaningful roles. This episode examines the hidden assumptions in power, money, and labor, and what happens when technology exposes the gaps in a system built on faith and untested ideas. Timestamps: 00:00 Intro 01:25 The Fate of the Rules-Based International Order 08:47 Interchangeable Baby Theory and Its Implications 17:58 The Stability of the US Dollar and Financial Systems 29:34 AI, Technology, and the Future of Society 34:07 The Craving for Violence in Media 34:29 Artificial Difficulty in Gaming and Crafting 34:57 Labor Supply and Demand in a Changing World 36:07 The Economic Uselessness of the Majority 36:38 Cultural Reflections on Indigenous Peoples and Welfare 38:11 AI's Impact on Employment Across Professions 38:34 The Dilemma of Meaningful Work vs. Automation 39:41 Autarky and Competing Economies 40:58 The Pursuit of Meaning Over Luxury 43:01 The Role of Technology in Shaping Labor 44:58 Cultural Stagnation and AI's Influence 46:05 The Aesthetic of AI and Over-Optimization Stay Connected: George on X: https://x.com/realGeorgeHotz Subscribe to Endgame: https://www.youtube.com/@endgamepodcast Amanda on X: https://x.com/amandacassatt Serotonin on X: https://x.com/serotonin_hq Links to Follow: Endgame on Spotify: https://open.spotify.com/episode/45B9szUxVXEwfCDA6uRxwq?si=HT9XXqF9Q2CcM9hfLbmkVg Endgame on Apple Podcasts: https://podcasts.apple.com/us/podcast/endgame-with-amanda-cassatt/id1801809440 Substack: https://substack.com/@UCInZsV3L1nDGoFjxoNUnPQQ
"If you are using technology to manipulate other people, you should be ashamed of yourself."In this episode of Endgame, Amanda Cassatt sits down with George Hotz to explore when technology empowers and when it traps. Using the framework of finite and infinite games, they define manipulation as placing someone in a system designed to extract from them without their awareness.They examine algorithmic trading, behavioral betting, and AI agents, asking where the ethical line lies between prediction and deception. The conversation moves from societal measures like GDP to electricity, steel, and Nvidia’s AI chip dominance, highlighting how software moats create real choke points of power.George and Amanda explore whether AI will create a cognitive divide between the upgraded and the monkey class, and whether opting into algorithmic comfort loops is a voluntary surrender of agency.This episode is about the ethics of control in a world where persuasion can be automated and scaled, and whether the games we build are infinite or finite, liberating or extractive.▶️TIMESTAMPS00:00 Intro01:25 The Rise of AI Tools and Productivity03:02 The Evolution of Coding: From Direct Coders to Managers of Agents05:48 Democratization of Coding: Access and Quality08:24 The Impact of AI on Software Production and Value10:56 Cultural Manipulation and the Role of Technology13:48 The Perpetual Underclass: Fears and Realities16:14 The Future of Power Dynamics in AI18:52 The Cost of AI Development and Its Implications21:23 The Role of Culture in Addressing AI Challenges33:29 Cultural Responsibility and Advertising Ethics35:41 The Role of Technology in Manipulation38:40 Ethics of Control and Manipulation43:45 Market Fairness and Regulation46:18 The Future of Capitalism and Financial Products51:28 Electricity Production as a Measure of Progress53:08 NVIDIA and the Future of AI Chips56:30 Cultural Shifts and the Monkey Class01:01:41 The Liminal Space of AI and Culture
As artificial intelligence agents become the dominant interface to the web, the question is no longer just “Who are you?” but “Who is acting on your behalf?” In this episode of Endgame, Amanda Cassatt sits down with Billions Network CEO Evin McMullen to examine the rapid shift toward agent-mediated internet use. At the end of last year, roughly one in every 31 website visits was conducted by a non-human actor, up sharply from just one in 200 earlier in the year. Increasingly, we are delegating our online activity to digital butlers.But delegation does not eliminate identity. It compounds it. Evin argues that we are moving beyond traditional KYC, Know Your Customer, into a new paradigm called KYA, Know Your Agent. If AI agents are making payments, accessing age-gated services, or interacting with financial and government systems, they must be able to prove who they represent. Identity becomes inheritable, and agents must cryptographically demonstrate the human or organization on whose behalf they act.This reframes the identity debate. The problem is no longer just login friction or platform data extraction. It is the structural need to bind autonomous systems to accountable humans. As armies of specialized sub-agents begin coordinating tasks across domains, payments, compliance, and trust all depend on pairing the person with the agent. Ultimately, identity becomes the backbone of the agentic internet. As humans step back from direct interaction and software takes the wheel, sovereignty shifts from logging in yourself to equipping your agents with portable, provable credentials so they can act and sign on your behalf. Timestamps 00:00 Introduction 01:25 Understanding Identity in the Digital Age 05:15 The Flaws of Current Identity Systems 09:59 Reimagining Identity Workflows 13:00 User Control and Data Ownership 14:30 Incentives and the Future of Identity 18:28 The Role of Crypto in Identity Management 22:27 Proving Human Identity in a Digital World 25:27 The Future of Agents and Identity 30:23 Navigating the New Digital Landscape 33:09 The Intersection of Technology and Regulation
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Apple Podcasts rankings via the Mato Topic Intelligence Platform.
Observed September 11, 2026. Cached outside the daily freshness window; the positions keep the date they were taken on.
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