Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health
Published by Joanne Kennedy
Health & Fitness
Alternative Health
Nutrition
The Histamine Well is a podcast for health practitioners and patients alike, bridging the gap between complex science and practical understanding. With a focus on histamine, methylation, and related health topics, the show translates advanced concepts into actionable insights for practitioners while empowering patients with accessible, evidence-based knowledge. Your host, Joanne Kennedy, is a naturopath and expert in histamine intolerance, MTHFR, and methylation. She is also an author and runs an online group coaching program for practitioners and students on histamine and methylation. Jo loves breaking down complex science into clear, easy-to-understand language, offering practical tips and the latest insights to empower you to take charge of your health.
53. Histamine Intolerance vs MCAS: How To Tell The Difference
Many people with flushing, hives, anxiety, brain fog, digestive issues, food sensitivities, and heart palpitations are told they have either histamine intolerance or Mast Cell Activation Syndrome (MCAS). While these conditions can look remarkably similar, they have very different underlying mechanisms—and understanding those differences is often the key to finding the right treatment. In this episode, Joanne explains the difference between histamine intolerance and MCAS, why symptoms overlap, and why some people continue to react despite following a low histamine diet. Drawing on her clinical experience, Joanne explores how histamine is processed in the body, the role of DAO and HNMT enzymes, common triggers for mast cell activation, and why addressing the root cause is essential for long-term recovery. She also discusses the connection between mould mycotoxins, gut dysfunction, SIBO, oxalates, nervous system dysregulation, and histamine-related illness, while sharing practical insights into how she approaches assessment and treatment in clinical practice. In this episode, you'll learn: The difference between histamine intolerance and Mast Cell Activation Syndrome (MCAS) Why these conditions share many of the same symptoms but require different treatment approaches How DAO and HNMT enzymes help regulate histamine in the body Common causes of histamine intolerance, including gut dysfunction, SIBO, mould exposure, oxalates, and hormone imbalances Why MCAS symptoms are often more severe, unpredictable, and triggered by non-food factors The connection between mould mycotoxins, chronic inflammation, and mast cell activation Which laboratory tests may be helpful—and why some commonly recommended tests have limited clinical value Joanne's clinical approach to identifying and treating the root causes of histamine-related symptoms Whether you're navigating histamine intolerance, suspect MCAS, or you're a healthcare practitioner wanting a deeper understanding of these complex conditions, this episode provides practical, evidence-informed insights to help you take the next step towards better health. ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!
52. Clinical Experience Of Working With Women On Bioidentical Oestrogen & Progesterone
Many women enter their 40s expecting a few hormonal changes, but are often unprepared for the anxiety, sleep disturbances, fatigue, low mood, histamine symptoms, weight changes, and nervous system shifts that can accompany perimenopause. In this episode, Joanne shares her clinical and personal experience working with women through perimenopause and menopause, including her own journey with bioidentical oestrogen and progesterone. She discusses the signs of low oestrogen and progesterone, the limitations of standard hormone testing, and how bioidentical hormone therapy may support women during this transition. You'll learn: The difference between perimenopause and menopause Common symptoms of low oestrogen and low progesterone How hormonal changes can influence histamine intolerance and mast cell activation Why hormone blood tests don't always tell the full story The potential benefits and challenges of bioidentical oestrogen and progesterone The connection between hormones, anxiety, sleep, mood, energy, libido, and weight Why hormone therapy should be individualised rather than one-size-fits-all Whether you're navigating perimenopause yourself or supporting women through this stage of life, this episode offers practical insights to help you better understand the relationship between hormones, histamine, and healthy ageing. ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!
51. Methylation Optimisation: What The Biohacking Trend Gets Wrong
Methylation has become one of the hottest topics in functional medicine, biohacking, and wellness. From MTHFR testing to methylated supplements, many people are being told that boosting methylation is the key to better energy, mood, detoxification, hormone balance, and longevity. But what if more methylation isn't always better? In this episode, Joanne explores the science behind methylation, the roles of MTHFR and COMT, and why relying solely on genetic reports can lead to inappropriate supplementation. Joanne explains the difference between undermethylation and overmethylation, the symptoms of excess methyl groups, and why many people experience worsening anxiety, insomnia, irritability, and other adverse effects when taking methylated supplements. Whether you're a practitioner, student, or someone navigating histamine intolerance, hormone imbalances, or chronic health concerns, this episode provides a balanced, evidence-informed perspective on one of today's most talked-about health trends. In this episode, you'll learn: What methylation is and why it's essential for health How methylation affects neurotransmitters, hormones, detoxification, and gene expression The difference between undermethylation and overmethylation The role of MTHFR, COMT, folate, and vitamin B12 in methylation pathways Common symptoms of excess methyl groups Why genetic testing alone doesn't tell the whole story The potential risks of methylated supplements A more personalised approach to methylation support ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!
50. Is PMDD a Histamine Problem? H1 and H2 Blockers Explained
Could histamine be contributing to Premenstrual Dysphoric Disorder (PMDD)? In this episode of The Histamine Well Podcast, Joanne explores the growing interest in the connection between PMDD, histamine intolerance, mast cell activation, and hormonal fluctuations. As more women report improvements in PMDD symptoms with antihistamines, the question is gaining attention: could histamine be a missing piece of the PMDD puzzle? Joanne breaks down the science behind the estrogen-histamine feedback loop, explains how histamine interacts with estrogen and progesterone throughout the menstrual cycle, and discusses why some women experience worsening mood symptoms during the luteal phase. You'll learn about the role of mast cells, neurotransmitters, neuroinflammation, and hormone sensitivity in PMDD, as well as the potential benefits and limitations of H1 and H2 antihistamines . Joanne also shares her clinical observations on histamine-related hormone symptoms and why addressing underlying drivers of histamine excess may be essential for long-term symptom improvement. In This Episode You'll Learn: What PMDD is and how it differs from PMS The relationship between histamine and women's hormones How estrogen can increase histamine levels The role of progesterone in histamine regulation Mast cell activation and hormone-related symptoms Why histamine may worsen anxiety, irritability, and mood swings The science behind H1 and H2 blockers Potential risks of long-term antihistamine use Histamine's effects on neurotransmitters including serotonin and dopamine The connection between PMDD, MCAS, and histamine intolerance Why methylation may play a role in PMDD symptoms Common root causes of histamine excess, including SIBO, mold exposure, oxalates, and gut dysfunction Natural strategies for addressing histamine-related hormone symptoms ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!
Persistent fatigue is one of the most common—and most frustrating—symptoms experienced by people with mould illness. Many find that despite sleeping more, resting, pacing themselves, and trying countless supplements, the exhaustion simply doesn't improve. In this episode of The Histamine Well Podcast , Joanne explores the hidden connection between mould illness and mitochondrial dysfunction, revealing why fatigue can persist long after mould exposure has been identified. You'll learn how three key factors often work together to impair cellular energy production: Mycotoxins and their direct toxic effects on mitochondria Sulfur depletion and reduced glutathione production Oxalate accumulation and mitochondrial stress Joanne explains how these mechanisms can disrupt ATP production, increase oxidative stress, and contribute to symptoms such as chronic fatigue, brain fog, muscle weakness, exercise intolerance, post-exertional malaise, pain sensitivity, and temperature dysregulation. This episode also explores the important relationship between mould exposure, gut dysbiosis, SIBO, sulfur metabolism, and oxalate overload—factors that are frequently overlooked when addressing ongoing fatigue and recovery from mould illness. Whether you're a practitioner, student, or someone navigating chronic health challenges, this episode provides valuable insights into the biological processes driving fatigue and what may need to be addressed for meaningful recovery. In this episode, you'll discover: How mould toxins damage mitochondrial function Why fatigue often persists despite rest and sleep The critical role of sulfur in energy production and detoxification How oxalates can contribute to mitochondrial dysfunction Common signs of mould-related mitochondrial impairment Why addressing mould exposure alone may not be enough for recovery ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!
48. How Mould Mycotoxins Cause SIBO
In this episode of The Histamine Well Podcast, Joanne explores the hidden connection between mould mycotoxins and Small Intestinal Bacterial Overgrowth (SIBO) — and why so many people with chronic digestive symptoms may be missing the true root cause of their gut dysfunction. If you’ve been struggling with bloating, reflux, constipation, diarrhea, histamine intolerance, food sensitivities, nausea, fatigue, or recurring SIBO that never fully resolves, this episode explains how mould exposure may be contributing to ongoing nervous system and digestive dysfunction. Joanne breaks down the mechanisms behind mould-related gut issues, including how mycotoxins impact the vagus nerve, gut motility, stomach acid production, bile flow, pancreatic enzymes, inflammation, and the migrating motor complex. She also discusses why chronic SIBO cases are often difficult to treat when mould toxicity is not properly addressed. In this episode, you’ll learn: Why mould illness and SIBO commonly occur together How poor vagal tone affects digestion and bacterial overgrowth The connection between mould, histamine intolerance, and mast cell activation Why low stomach acid and sluggish bile flow can worsen gut symptoms How chronic inflammation disrupts gut motility and digestive function Why antibiotics and herbal antimicrobials may not fully resolve SIBO The importance of mould testing in chronic gut health conditions #SIBO #MouldIllness #HistamineIntolerance #GutHealth #Mycotoxins #MCAS #FunctionalMedicine #DigestiveHealth #MoldToxicity #VagusNerve ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!
47. The Bile-Histamine Connection: SIBO, Estrogen, Mold & Oxalates Explained
What if your histamine symptoms aren’t just about food? In this episode of the The Histamine Well Podcast, Joanne explores the overlooked connection between bile flow, histamine intolerance, SIBO, estrogen dominance, mold exposure, oxalates, methylation, and chronic inflammation. Bile plays a critical role in digestion, detoxification, hormone clearance, and microbial balance in the gut. When bile flow becomes sluggish, it can contribute to bacterial overgrowth, poor fat digestion, impaired estrogen detoxification, oxalate accumulation, and worsening histamine symptoms. In this episode, Joanne explains: How poor bile flow contributes to histamine intolerance Why mold toxicity and mycotoxins affect the liver and gallbladder The vicious cycle between SIBO and bile dysfunction How estrogen dominance impacts bile flow and histamine Why oxalates can worsen inflammation and histamine symptoms The role of methylation and phosphatidylcholine in healthy bile production How vagus nerve dysfunction affects digestion and bile release Common signs and symptoms of poor bile flow This episode is essential listening for anyone struggling with histamine intolerance, MCAS, gut health issues, bloating, hormone imbalances, mold illness, chronic inflammation, food sensitivities, or unexplained digestive symptoms. 🎧 Subscribe to The Histamine Well Podcast for evidence-based conversations on histamine intolerance, methylation, SIBO, mold illness, women’s hormones, and functional medicine. #HistamineIntolerance #SIBO #GutHealth #MoldIllness #EstrogenDominance #Oxalates #Methylation #FunctionalMedicine #BileFlow ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!
46. High Homocysteine: Histamine, Methylation & Why You Might Not Tolerate Methylated B Vitamins
Can methylated B vitamins make your symptoms worse instead of better? In this episode of The Histamine Well Podcast , Joanne explains the connection between high homocysteine, histamine intolerance, methylation, and why some people react poorly to methylated nutrients. High homocysteine is associated with cardiovascular disease, cognitive decline, inflammation, and neurological health concerns — yet lowering it isn’t always simple. Many people experience headaches, anxiety, insomnia, digestive issues, skin flare-ups, or worsening histamine symptoms when taking methylfolate or methyl B12. Joanne breaks down the methylation cycle in simple terms, explains the role of histamine in nutrient tolerance, and explores how genetics such as the MTHFR gene mutation and COMT enzyme activity may influence how your body responds to methylated supplements. In this episode, you’ll learn: • What high homocysteine means and why it matters • The connection between homocysteine and methylation • Why methylated B vitamins can trigger symptoms • Histamine intolerance and supplement sensitivity • The role of MTHFR, COMT, and methylation pathways • Overmethylation vs undermethylation explained • Practical clinical insights for improving tolerance to methyl nutrients Whether you're a practitioner, student, or navigating your own health journey, this episode offers practical education on histamine, methylation, gut health, and root-cause healing. Subscribe to The Histamine Well Podcast for expert discussions on histamine intolerance, women’s hormones, functional medicine, gut health, methylation, and integrative wellness. ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!
Q&A. Should I Take Calcium-D-Glucarate Whilst On HRT Oestrogen?
Can you take Calcium-D-Glucarate while on HRT estrogen during menopause? In this short Q&A episode of The Histamine Well Podcast , Joanne explores the relationship between estrogen detoxification, hormone replacement therapy (HRT), menopause, gut health, and histamine-related symptoms. Many women are advised to take supplements that support estrogen detox, but is this always the right approach when using bioidentical hormones or estrogen therapy? Joanne explains why Calcium-D-Glucarate may not be beneficial for menopausal women on HRT, how estrogen balance works during menopause, and why understanding your hormone dose matters for symptom relief and long-term wellbeing. This episode also covers: The role of estrogen during menopause and HRT Why over-detoxifying estrogen may worsen symptoms The connection between beta-glucuronidase, the estrobolome, and gut microbiome health Histamine intolerance, hormone imbalance, and menopause symptoms Natural considerations for estrogen metabolism and hormone support Why gut health may be more important than estrogen detox supplements If you're navigating menopause, hormone replacement therapy, estrogen dominance symptoms, histamine intolerance, or gut-related hormone imbalance, this episode offers practical clarity backed by clinical naturopathic insight. Subscribe to The Histamine Well Podcast for expert conversations on histamine intolerance, methylation, gut health, hormones, mold illness, MCAS, menopause, and functional medicine approaches to healing. ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!
45. Case Study: SIBO, Histamine Intolerance & Hormonal Imbalance
In this episode of The Histamine Well, Joanne shares a powerful clinical case study exploring the connection between SIBO (Small Intestinal Bacterial Overgrowth), histamine intolerance, hormonal imbalance, estrogen dominance, gut health, bloating, acne, fatigue, and PMS symptoms. This episode follows the journey of a 37-year-old woman who experienced rapid body changes over two years — including unexplained weight gain, chronic bloating, severe PMS, hormonal acne, headaches, fluid retention, breast tenderness, digestive discomfort, and low energy. Through functional testing and a naturopathic treatment approach, Joanne uncovers how gut dysfunction, histamine overload, and hormone imbalance can work together to drive chronic symptoms. You’ll discover how SIBO contributes to nutrient malabsorption, inflammation, estrogen dominance, histamine intolerance, and digestive dysfunction, along with why symptoms such as bloating, fatigue, skin issues, and menstrual changes are often connected. In this episode, Joanne discusses: The link between SIBO, histamine intolerance, and hormonal imbalance Why bloating, PMS, headaches, and acne may stem from gut dysfunction The difference between hydrogen and methane SIBO How nutrient deficiencies affect hormones, mood, and energy Why is bowel motility essential for successful SIBO treatment The role of biofilms in persistent gut symptoms Functional medicine strategies for improving gut and hormone health Whether you are a practitioner, student, or someone navigating digestive and hormone-related symptoms, this episode offers practical insight into the deep connection between gut health, histamine, hormones, and systemic inflammation. ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!
Q&A. How Do Epsom Salt Baths Work & Why Are They Good For Me?
Can something as simple as an Epsom salt bath support detoxification, gut health, and nervous system regulation? In this Q&A episode of The Histamine Well Podcast , Joanne breaks down the clinical benefits behind Epsom salt baths (magnesium sulfate) —and why they’re often recommended for patients dealing with histamine intolerance, sulfur issues, chronic fatigue, and food sensitivities . You’ll learn how magnesium and sulfate work together in the body, how they’re absorbed through the skin, and why this gentle therapy can support everything from sleep and muscle relaxation to liver detox pathways and gut lining integrity . 🎧 In this episode, you’ll learn: What Epsom salt (magnesium sulfate) actually is How transdermal absorption supports magnesium levels The role of sulfate in liver detoxification (sulfation pathway) Why sulfate is essential for gut lining, skin, and connective tissue health How Epsom salt baths support the nervous system and stress response Why they’re helpful for people with histamine intolerance, sulfur sensitivity, mold illness, and oxalate issues How to safely start Epsom salt baths (especially if sensitive) Epsom salt baths aren’t just about relaxation—they’re a powerful, low-cost tool to support detox pathways, reduce stress, and restore key nutrient levels without burdening the digestive system. This makes them especially beneficial for those who struggle to tolerate supplements or are dealing with complex chronic symptoms. If you’ve ever wondered whether Epsom salt baths actually “do anything”—this episode will give you a clear, science-backed answer and practical guidance. Tune in to learn how to use this simple therapy effectively and safely. ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!
44. Sulfur Intolerace Explained: What Is It? Why Does It Happen? How Does It Increase Histamine?
Are “healthy” foods like broccoli, garlic, eggs, or red meat making you feel worse instead of better? In this episode of The Histamine Well Podcast , Joanne breaks down one of the most overlooked root causes of food sensitivity, gut symptoms, and chronic fatigue: sulfur metabolism dysfunction. If you’ve been struggling with histamine intolerance, unexplained food reactions, bloating, brain fog, or fatigue, this episode will help you understand what may really be going on beneath the surface. 🎧 In this episode, you’ll learn: What “sulfur intolerance” actually is (and why that term is misleading) The difference between sulfide, sulfite, and sulfate How disrupted sulfur metabolism impacts your gut, energy, skin, and brain The connection between hydrogen sulfide gas and mitochondrial dysfunction Why sulfur issues can trigger or worsen histamine intolerance Hidden sources of sulfur in foods, supplements, and water The role of methylation, molybdenum, and gut bacteria Key symptoms of sulfur imbalance (including bloating, fatigue, headaches, and food sensitivities) Many people are told to simply eliminate more and more foods—but what if the real issue isn’t the food itself? This episode offers a functional medicine perspective to help you understand the deeper biochemical pathways behind your symptoms and why your body may be reacting the way it is. Understanding sulfur metabolism can completely shift how you approach healing—and may explain why nothing else has worked. ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!
Q&A. Why Does My Anxiety Get Worse at Night or Wake Me Up at 3am?
Do you find your anxiety worsening at night—or waking you suddenly between 2AM and 4AM with a racing heart and intrusive thoughts? In this Clarity Session Q&A, Joanne explores one of the most common patterns seen in clinic: night-time anxiety and early morning wake-ups —and why this is often more than just a psychological issue. This episode explains the physiological root causes of anxiety at night , including the critical role of blood sugar regulation, liver glycogen stores, and stress hormones like cortisol and adrenaline . When blood sugar drops overnight, your body triggers a stress response—leading to symptoms that can feel like panic attacks. You’ll learn: Why anxiety often spikes between 2AM–4AM The connection between low blood sugar and night-time panic How cortisol and adrenaline disrupt sleep Common triggers like skipping meals, low protein intake, and caffeine use Why this pattern is especially common in perimenopause Simple strategies to stabilize blood sugar and improve sleep quality Joanne also shares practical tips, including how a protein-based evening snack may help prevent early morning wake-ups and reduce overnight anxiety. If you’ve been struggling with disrupted sleep, anxious thoughts at night, or waking at 3AM feeling wired, this episode offers a new perspective—and actionable steps to support your body. ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!
43. Blood Sugar & Anxiety in Women: The Hidden Cause of Chronic Anxiety
Are you struggling with anxiety, overwhelm, or constant nervous system dysregulation—despite normal lab results? In this episode of The Histamine Well Podcast , Joanne uncovers one of the most overlooked root causes of anxiety in women: blood sugar instability. Learn how blood sugar spikes and crashes can trigger cortisol and adrenaline, creating symptoms that feel exactly like anxiety disorders. Joanne breaks down why this often goes undiagnosed, even when glucose, insulin, and HbA1c levels appear normal. This episode explores the connection between blood sugar, hormones, histamine, gut health, and neurotransmitter production—and why women are particularly vulnerable, especially during high stress or perimenopause. You’ll also discover real-life patterns seen in clinical practice, including: High-achieving women relying on coffee and insufficient protein intake, contributing to blood sugar instability Busy mothers under-eating and overwhelmed Women using intermittent fasting in ways that disrupt hormones Hidden links between histamine intolerance and blood sugar imbalance If you’ve ever felt like your anxiety “doesn’t make sense,” this episode will help you understand what’s really happening in your body—and what to do about it. ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!
Q&A. Why Do I Still Have Inflammation When My CRP & ESR Are Normal?
If your blood tests are “normal”… why do you still feel inflamed? In this Q&A Clarity Session of The Histamine Well Podcast , Joanne answers a deeply important and often overlooked question: why symptoms of inflammation can persist even when CRP and ESR markers come back normal . Many people are told everything is “fine” based on standard blood work—yet continue to experience fatigue, brain fog, skin issues, gut dysfunction, and hormonal imbalances. This episode explains why that disconnect happens and what may actually be driving your symptoms. CRP (C-reactive protein) and ESR (erythrocyte sedimentation rate) are commonly used markers for inflammation—but they primarily detect acute, systemic inflammation , not the chronic low-grade inflammation seen in many complex health conditions. In this episode, you’ll learn: Why CRP and ESR can be normal despite ongoing symptoms The difference between acute vs chronic low-grade inflammation Common drivers of hidden inflammation (gut issues, histamine, mold, blood sugar imbalance, stress) How inflammation can show up as skin, neurological, hormonal, and digestive symptoms Why patients are often dismissed despite real underlying issues If you’ve ever been told “your labs are normal” but still don’t feel well, this episode will give you the clarity and validation you’ve been looking for. This is essential listening for anyone dealing with: Histamine intolerance Chronic inflammation Gut health issues (SIBO, candida, dysbiosis) Hormonal imbalances Unexplained symptoms despite normal blood tests 🎧 Subscribe to The Histamine Well Podcast for more expert insights on root-cause healing, inflammation, and complex chronic conditions. ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!
42. Why Your Hormones Haven't Improved Despite Treatment - The Role of Inflammation, Histamine & Methylation
In this in-depth episode of The Histamine Well Podcast , Joanne explores why hormone symptoms often persist despite treatment, and what may be driving this beneath the surface. Drawing on clinical observation and biochemistry, Joanne explains how chronic inflammation, histamine dysregulation, and methylation imbalances interact to disrupt hormonal signaling, ovulation, and recovery. If you’ve tried supplements, improved your diet, and still experience symptoms like PMS, PMDD, anxiety, insomnia, migraines, or hormonal acne, this episode provides a deeper framework for understanding why. What You’ll Learn Why hormones may not improve despite treatment How inflammation disrupts ovulation and lowers progesterone The connection between histamine intolerance and estrogen dominance Why symptoms worsen around ovulation and before your period The role of methylation in estrogen detoxification Differences between overmethylation and undermethylation Why some supplements may worsen symptoms Key drivers behind PMS, anxiety, sleep issues, and hormonal imbalance ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!
Q&A. Are Bioidentical Hormones Actually Natural?
Are bioidentical hormones truly “natural”—or is that just clever marketing? In this Q&A Clarity Session of The Histamine Well Podcast, Joanne breaks down one of the most common and misunderstood questions in women’s health: what bioidentical hormones actually are, where they come from, and how they differ from both synthetic hormones and herbal remedies. Many women exploring hormone replacement therapy (HRT) feel uncertain about what they’re putting into their bodies—especially when terms like “natural,” “plant-based,” and “bioidentical” are used interchangeably. In this episode, we clarify the science in a simple, grounded way so you can make informed decisions about your health. You’ll learn: What “bioidentical hormones” really means How hormones derived from wild yam and soy are processed The difference between plant compounds and human-identical hormones Why bioidentical doesn’t mean “straight from nature” How these hormones interact with your body Common misconceptions about HRT and hormone therapy If you’ve ever struggled with hormone imbalance, menopause symptoms, or felt worse on hormone therapy, this episode will help you understand what’s actually happening beneath the surface. This is essential listening for women navigating perimenopause, menopause, or anyone questioning whether hormone therapy is right for them. ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!
41. Can’t Tolerate HRT? The Hidden Reason Most Women Miss
Can’t tolerate HRT? This episode explores the connection between histamine intolerance, hormone replacement therapy (HRT), SIBO, gut health, menopause symptoms, and hormone imbalance in women. Joanne Kennedy shares a clinical case study showing how histamine overload and gut dysfunction can worsen HRT side effects like brain fog, fatigue, mood swings, and skin reactions. Learn how the estrogen-histamine connection, gut health, and inflammation impact hormone tolerance—and why addressing SIBO and histamine intolerance may help restore balance. Perfect for women experiencing menopause symptoms, HRT intolerance, or ongoing hormone imbalances. 🌿 In This Episode, You’ll Learn: Why histamine intolerance can worsen HRT side effects The connection between estrogen and histamine (and why it matters) How gut issues like SIBO drive inflammation and hormone imbalance Common symptoms: brain fog, fatigue, low mood, skin reactions Why fixing the gut can improve hormone tolerance A real clinical approach to restoring balance naturally 💡 Who This Episode Is For: Women struggling with HRT side effects Those experiencing menopause symptoms like fatigue, brain fog, and low mood Anyone with histamine intolerance or food sensitivities Practitioners looking to understand the gut-hormone connection For worldwide online consultations via Zoom, visit: www.joannekennedynaturopathy.com ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!
Q&A. How Does Sulforaphane Work in the Body? Hint: It Switches On Your Protective Genes
In this Q&A Clarity Session of The Histamine Well Podcast , naturopath Joanne Kennedy explains the science behind sulforaphane and how it activates the NRF2 pathway , often referred to as the body’s “master switch” for protection and repair. Rather than acting as a simple antioxidant, sulforaphane works at a deeper level—helping to switch on a network of protective genes responsible for detoxification, antioxidant production, inflammation control, and immune regulation This episode breaks down complex science into simple, practical insights—perfect for both practitioners and those navigating chronic health issues. In This Episode, we discussed: What sulforaphane is and how it works in the body The role of the NRF2 pathway in detoxification and inflammation How sulforaphane supports antioxidant production and immune health Why gene expression (not just supplements) matters in healing How this applies to histamine intolerance, chronic inflammation, and gut health Who This Episode Is For: Those interested in functional medicine and natural health People dealing with inflammation, histamine intolerance, or detox issues Practitioners wanting to understand sulforaphane and NRF2 Anyone looking to support their body’s natural detox and repair systems ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!
40. The GEMM Protocol: A Deeper Approach To Why Your Gut Isn't Healing - And What To Do About It
In this episode of The Histamine Well Podcast, Joanne speaks with nutritional biochemist Dr. Christine Houghton about the GEMM Protocol (Gut Ecology & Metabolic Modulation) — a science-based approach to restoring gut health by repairing the gut lining and activating protective genes. Learn how sulforaphane, NRF2 activation, and targeted microbiome support can help improve gut inflammation, histamine intolerance, food sensitivities, and chronic illness. In this episode, you’ll learn: What the GEMM Protocol is and how it works How sulforaphane activates the NRF2 pathway and protective genes Why traditional antimicrobial gut protocols can worsen dysbiosis How gut inflammation contributes to histamine intolerance and food sensitivities The role of heat-killed probiotics and immune signaling in gut repair Why restoring the gut lining can improve conditions throughout the body How diet and prebiotics support microbiome recovery Why some patients with chronic illness react to many supplements ✨ Want more? Follow on Instagram , Facebook , and YouTube for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance —your step-by-step guide to manage your histamine intolerance effectively. 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026! 📆 Work with us 1:1! Book a consultation and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here!
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