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Published by Sonya Del Tredici and John Keenan
We believe that addiction is a disease that can be treated, and we want to help you stay up to date with the latest research that you can use in your addiction medicine practice.
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We discuss an article about the benefits of continuing buprenorphine, methadone, and naltrexone long-term. Hayes CJ, Raciborski RA, Acharya M, Noor NB, Nunes EV, Winhusen TJ. Evaluating the optimal duration of medication treatment for opioid use disorder. Addiction. 2026 Apr;121(4):922-933. doi: 10.1111/add.70211. Epub 2026 Jan 7. PMID: 41501983; PMCID: PMC12980296. We also discuss increasing reimbursement for smoking cessation counselling, and VA trials of GLP-1s for alcohol use disorder. StatNews: Quitting smoking is hard. A Medicare change may push doctors to give more help Medicare proposed 2027 fee schedule (a little light reading) To make public comments on the 2027 fee schedule Military Times: VA launches trial to test GLP-1 medication for alcohol use disorder in veterans --- This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ --- Original theme music: composed and performed by Benjamin Kennedy Audio editing: Michael Bonanno Executive producer: Dr. Patrick Beeman A podcast from Ars Longa Media --- This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice. The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. --- Email: addictionmedicinejournalclub@gmail.com Facebook: @AddictionMedJC Facebook Group: Addiction Medicine Journal Club Instagram: @AddictionMedJC Threads: @AddictionMedJC YouTube: addictionmedicinejournalclub Twitter/X: @AddictionMedJC --- Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. Learn more about your ad choices. Visit megaphone.fm/adchoices
71-80 Round-Up Quick summaries of our last 10 articles, for busy people. 71. Buprenorphine and Dental Problems 72. Symptom-Triggered Alcohol Withdrawal Management Over Telemedicine 73. Long-Term Opioid Use After a First Prescription 74. Quick-Start Injectable Buprenorphine 75. Contingency Management for Stimulant Use Disorder and Mortality 76. Injectable Buprenorphine in Pregnancy 77. Epic’s Opioid Risk Score 78. Treating Alcohol Use Disorder in Patients with Severe Liver Disease 79. Direct-to-Inject Buprenorphine 80. Phenobarbital for Alcohol Withdrawal Full citations, for those who love references: Tuan WJ, Clebak KT, Jawadi E, Snyder J, Zgierska AE. Risk of Oral Health Problems in Adults With Opioid Use Disorder Treated With Transmucosal Buprenorphine. J Addict Med. 2025 Sep-Oct 01;19(5):529-535. doi: 10.1097/ADM.0000000000001453. Epub 2025 Mar 10. PMID: 40062592. Sloan ME, Ngoy A, Xiao KB, Barker B, Buckley L, Fodor M, Hardy K, Hendershot CS, Kahan M, La Fleur S, Le Foll B, Manicone M, Sanches M, Simpkin E, Quilty LC, Wyman J, Tang VM, Bozinoff N. Symptom-Triggered Alcohol Withdrawal Management Delivered Over Telemedicine. J Addict Med. 2025 Nov-Dec 01;19(6):708-715. doi: 10.1097/ADM.0000000000001491. Epub 2025 May 1. PMID: 40310714; PMCID: PMC12352377. Smith AM, Shah A, Martin BC. An updated view on the influence of initial opioid prescription characteristics on long-term opioid use among opioid naïve patients. Drug Alcohol Depend. 2024 Dec 1;265:112463. doi: 10.1016/j.drugalcdep.2024.112463. Epub 2024 Oct 24. PMID: 39549364; PMCID: PMC11924105. Shiwach R, Le Foll B, Alho H, Dunn KE, Strafford S, Zhao Y, Dobbins RL. Rapid vs Standard Induction to Injectable Extended-Release Buprenorphine: A Randomized Clinical Trial. JAMA Netw Open. 2025 Oct 1;8(10):e2537319. doi: 10.1001/jamanetworkopen.2025.37319. PMID: 41085986; PMCID: PMC12522003. Coughlin LN, Tomlinson DC, Zhang L, Kim HM, Frost MC, Khazanov G, McKay JR, DePhilippis D, Lin LA. Contingency Management for Stimulant Use Disorder and Association With Mortality: A Cohort Study. Am J Psychiatry. 2025 Nov 1;182(11):1016-1023. doi: 10.1176/appi.ajp.20250053. Epub 2025 Sep 10. PMID: 40926572. Winhusen TJ, Lofwall MR, Kropp F, Lewis D, Smid MC, Young JL, Hodgkins C, Krans EE, Hansen Z, Wachman EM, Schiff DM, Guille C, Rudolf V, Chowdhury T, Leeman L, Lewis M, Matthews AG, Cochran G, King J, Wilder C, Rosa C. Extended-Release vs Sublingual Buprenorphine in Pregnancy Through 12 Months Post Partum: A Randomized Clinical Trial. JAMA Intern Med. 2026 May 1;186(5):533-543. doi: 10.1001/jamainternmed.2026.0057. Hooker SA, Rossom RC, Haapala J, Crain AL, Miley K, Olson AW, Kane S, Christensen K, O'Connor PJ, Bart G, Wright EA. External Validation of Epic's Risk of Opioid Abuse and Overdose Model Among Primary Care Patients in Three Health Systems. J Gen Intern Med. 2026 Feb 17. doi: 10.1007/s11606-026-10257-1. Epub ahead of print. PMID: 41703383. Sundaresh R, Singh J, Meza J, Saab S, Shetty A. Medications for Alcohol Use Disorder Among Patients With Severe Alcohol-Related Liver Disease. JAMA Netw Open. 2026 Feb 2;9(2):e2559016. doi: 10.1001/jamanetworkopen.2025.59016. PMID: 41670995; PMCID: PMC12895287. Rosenwohl-Mack S, Heeney M, Samuel L, Anderson E, Herring AA, Sirey LR, Peterson D, Bazazi AR, Snyder H, Suen LW. Outpatient initiation of direct-to-inject buprenorphine. Drug Alcohol Depend. 2026 Jan 1;278:113011. doi: 10.1016/j.drugalcdep.2025.113011. Epub 2025 Dec 19. PMID: 41442975; PMCID: PMC13271074. Wolpaw BJ, Oren H, Quinnan-Hostein L, Bradley KA, Johnson NJ, Hallgren KA, Gupta A, Kim HN, Granich MA, Steel TL. Hospital-Wide Implementation, Clinical Outcomes, and Safety of Phenobarbital for Alcohol Withdrawal. JAMA Netw Open. 2025 Aug 1;8(8):e2528694. doi: 10.1001/jamanetworkopen.2025.28694. PMID: 40853658; PMCID: PMC12379078. --- This episode does not offer CME, but others do. You can get category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. Go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ --- Original theme music: composed and performed by Benjamin Kennedy Audio editing: Michael Bonanno Executive producer: Dr. Patrick Beeman A podcast from Ars Longa Media --- This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice. The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. --- Email: addictionmedicinejournalclub@gmail.com Facebook: @AddictionMedJC Facebook Group: Addiction Medicine Journal Club Instagram: @AddictionMedJC Threads: @AddictionMedJC YouTube: addictionmedicinejournalclub Twitter/X: @AddictionMedJC --- Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. Learn more about your ad choices. Visit megaphone.fm/adchoices
In episode 81 we discuss using mirtazapine to treat methamphetamine use disorder. McKetin R, Shoptaw S, Saunders L, et al. Mirtazapine for Methamphetamine Use Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2026;83(6):581–589. doi:10.1001/jamapsychiatry.2026.0159 We also discuss behavioral treatments added to buprenorphine, and how the FDA is promoting flavored nicotine products. JAMA Network Open: Adjunctive Psychosocial Interventions and Opioid Abstinence Among Patients Receiving Buprenorphine NBC News: Some ZYN nicotine pouches can be sold as safer than cigarettes, FDA says --- This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ --- Original theme music: composed and performed by Benjamin Kennedy Audio editing: Michael Bonanno Executive producer: Dr. Patrick Beeman A podcast from Ars Longa Media --- This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice. The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. --- Email: addictionmedicinejournalclub@gmail.com Facebook: @AddictionMedJC Facebook Group: Addiction Medicine Journal Club Instagram: @AddictionMedJC Threads: @AddictionMedJC YouTube: addictionmedicinejournalclub Twitter/X: @AddictionMedJC --- Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. Learn more about your ad choices. Visit megaphone.fm/adchoices
In episode 80 we discuss phenobarbital for alcohol withdrawal in the hospital. Wolpaw BJ, Oren H, Quinnan-Hostein L, Et al. Hospital-Wide Implementation, Clinical Outcomes, and Safety of Phenobarbital for Alcohol Withdrawal. JAMA Netw Open. 2025 Aug 1;8(8):e2528694. We also discuss DEA scheduling of 7-OH (from kratom) and the Trump administration’s pro-alcohol policies. The Hill: DEA moves to ban opioid-like kratom compound 7-OH Stat News: Even with MAHA, Trump administration has gone soft on alcohol --- This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ --- Original theme music: composed and performed by Benjamin Kennedy Audio editing: Michael Bonanno Executive producer: Dr. Patrick Beeman A podcast from Ars Longa Media --- This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice. The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. --- Email: addictionmedicinejournalclub@gmail.com Facebook: @AddictionMedJC Facebook Group: Addiction Medicine Journal Club Instagram: @AddictionMedJC Threads: @AddictionMedJC YouTube: addictionmedicinejournalclub Twitter/X: @AddictionMedJC --- Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. Learn more about your ad choices. Visit megaphone.fm/adchoices
In episode 79 we discuss an article about starting long-acting injectable buprenorphine without a sublingual test dose. Rosenwohl-Mack S, Heeney M, Samuel L, Anderson E, Herring AA, Sirey LR, Peterson D, Bazazi AR, Snyder H, Suen LW. “Outpatient initiation of direct-to-inject buprenorphine.” Drug and alcohol dependence vol. 278 (2026): 113011. doi:10.1016/j.drugalcdep.2025.113011 We also discuss keeping up with addiction medicine news from the current administration, and an articlre commendation from one of our listeners. KFF: The independent source for health policy research, polling, and news. KFF: View the Latest: Substance Use KFF: Tracking Key Mental Health and Substance Use Policy Actions Under the Trump Administration CBS News: New White House drug abuse strategy floats wastewater testing, AI, more treatment and faith-based options Psychological Medicine: Risk factors for the development of opioid use disorder after first opioid prescription: a Swedish national study --- This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ --- Original theme music: composed and performed by Benjamin Kennedy Audio editing: Michael Bonanno Executive producer: Dr. Patrick Beeman A podcast from Ars Longa Media --- This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice. The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. --- Email: addictionmedicinejournalclub@gmail.com Facebook: @AddictionMedJC Facebook Group: Addiction Medicine Journal Club Instagram: @AddictionMedJC Threads: @AddictionMedJC YouTube: addictionmedicinejournalclub Twitter/X: @AddictionMedJC --- Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. Learn more about your ad choices. Visit megaphone.fm/adchoices
In episode 78 we discuss treating alcohol use disorder in patients with severe liver disease. Sundaresh R, Singh J, Meza J, Saab S, Shetty A. Medications for Alcohol Use Disorder Among Patients With Severe Alcohol-Related Liver Disease. JAMA Netw Open. 2026;9(2):e2559016. doi:10.1001/jamanetworkopen.2025.59016 We also discuss the final dissolution of Perdue Pharma. The Guardian: Purdue Pharma to be dissolved as judge approves criminal sentence in opioid case --- This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ --- Original theme music: composed and performed by Benjamin Kennedy Audio editing: Michael Bonanno Executive producer: Dr. Patrick Beeman A podcast from Ars Longa Media --- This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice. The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. --- Email: addictionmedicinejournalclub@gmail.com Facebook: @AddictionMedJC Facebook Group: Addiction Medicine Journal Club Instagram: @AddictionMedJC Threads: @AddictionMedJC YouTube: addictionmedicinejournalclub Twitter/X: @AddictionMedJC --- Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. Learn more about your ad choices. Visit megaphone.fm/adchoices
We love a good poster session. This episode we are joined by Dr. Anthony Accurso to review some of our favorite posters from the American Society of Addiction Medicine’s 2026 Annual Meeting. All the Posters from ASAM 57 Posters profiled here: 12: Real-World Analysis of Buprenorphine-Precipitated Opioid Withdrawal: A Multicenter Study 38: Co-Located Bridge Clinic/Withdrawal Management Unit Reduces 30-Day Readmits Using LA-Bup Injections 55: Increased Naltrexone Prescribed for Alcohol Use After Changes to Obesity Treatment Protocol 62: Comorbidities and Mortality in Substance Use Disorder Patients With Nicotine Dependence 115: Higher Buprenorphine Doses Improve Treatment Engagement and Outcomes in Opioid Use Disorder 119: Closing the Gap: Inpatient Methadone and Telehealth OTP Enrollment 142: Naltrexone Treatment for AI Chatbot Addiction in Adolescent With ASD and ADHD --- Original theme music: composed and performed by Benjamin Kennedy Audio editing: Michael Bonanno Executive producer: Dr. Patrick Beeman A podcast from Ars Longa Media --- This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice. The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. --- Email: addictionmedicinejournalclub@gmail.com Facebook: @AddictionMedJC Facebook Group: Addiction Medicine Journal Club Instagram: @AddictionMedJC Threads: @AddictionMedJC YouTube: addictionmedicinejournalclub Twitter/X: @AddictionMedJC --- Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. Learn more about your ad choices. Visit megaphone.fm/adchoices
Finally, an external validation of Epic’s controversial risk of opioid abuse and overdose model. Hooker, S.A., Rossom, R.C., Haapala, J. et al. External Validation of Epic’s Risk of Opioid Abuse and Overdose Model Among Primary Care Patients in Three Health Systems. J GEN INTERN MED (2026). We also discuss financial consequences of online sports betting, and Trump’s initiative to encourage psychedelic therapy. The Financial Consequences of Legalized Sports Gambling BMJ: Online gambling requires greater government regulation Reuters: Trump signs order to accelerate access to psychedelic drug treatments --- This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ --- Original theme music: composed and performed by Benjamin Kennedy Audio editing: Michael Bonanno Executive producer: Dr. Patrick Beeman A podcast from Ars Longa Media --- This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice. The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. --- Email: addictionmedicinejournalclub@gmail.com Facebook: @AddictionMedJC Facebook Group: Addiction Medicine Journal Club Instagram: @AddictionMedJC Threads: @AddictionMedJC YouTube: addictionmedicinejournalclub Twitter/X: @AddictionMedJC --- Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. Learn more about your ad choices. Visit megaphone.fm/adchoices
A new randomized controlled trial of injectable buprenorphine in pregnancy. Winhusen TJ, Lofwall MR, Kropp F, et al. Extended-Release vs Sublingual Buprenorphine in Pregnancy Through 12 Months Post Partum: A Randomized Clinical Trial. JAMA Intern Med. Published online March 16, 2026. We also discuss the kindling effect in opioid withdrawal, and how insurance changes can destabilize patients in recovery. Psychopharmacology: Repeated fentanyl abstinence intensifies opioid withdrawal and induces a proinflammatory state in striatal microglia STAT: How the insurance system quietly undoes recovery from addiction --- This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ --- Original theme music: composed and performed by Benjamin Kennedy Audio editing: Michael Bonanno Executive producer: Dr. Patrick Beeman A podcast from Ars Longa Media --- This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice. The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. --- Email: addictionmedicinejournalclub@gmail.com Facebook: @AddictionMedJC Facebook Group: Addiction Medicine Journal Club Instagram: @AddictionMedJC Threads: @AddictionMedJC YouTube: addictionmedicinejournalclub Twitter/X: @AddictionMedJC --- Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. Learn more about your ad choices. Visit megaphone.fm/adchoices
In episode 75 we discuss the mortality benefit of contingency management for stimulant use disorder. Coughlin LN, Tomlinson DC, Zhang L, Kim HM, Frost MC, Khazanov G, McKay JR, DePhilippis D, Lin LA. Contingency Management for Stimulant Use Disorder and Association With Mortality: A Cohort Study. Am J Psychiatry. 2025 Nov 1;182(11):1016-1023. We also discuss telemedicine regulations. ASAM: DEA and HHS Extend COVID-Era Telemedicine Prescribing Flexibilities Through 2026 --- This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ --- Original theme music: composed and performed by Benjamin Kennedy Audio editing: Michael Bonanno Executive producer: Dr. Patrick Beeman A podcast from Ars Longa Media --- This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice. The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. --- Email: addictionmedicinejournalclub@gmail.com Facebook: @AddictionMedJC Facebook Group: Addiction Medicine Journal Club Instagram: @AddictionMedJC Threads: @AddictionMedJC YouTube: addictionmedicinejournalclub Twitter/X: @AddictionMedJC --- Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. Learn more about your ad choices. Visit megaphone.fm/adchoices
In episode 74 we discuss an article about starting injectable buprenorphine after just one sublingual dose. Shiwach R, Le Foll B, Alho H, et al. Rapid vs Standard Induction to Injectable Extended-Release Buprenorphine: A Randomized Clinical Trial. JAMA Netw Open. 2025;8(10):e2537319. We will be presenting high-yield articles that changed our practices at the Pennsylvania Society of Addiction Medicine annual Addiction Symposium (virtually) and Sonya will be doing a workshop on benzodiazepine tapering at the ASAM conference in April in San Diego. Stop by and say Hi! PSAM Addiction Symposium, Virtual, Saturday, March 7th, 2026 57th ASAM Annual Conference, San Diego, April 23rd-26th, 2006 --- This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ --- Original theme music: composed and performed by Benjamin Kennedy Audio editing: Michael Bonanno Executive producer: Dr. Patrick Beeman A podcast from Ars Longa Media --- This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice. The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. --- Email: addictionmedicinejournalclub@gmail.com Facebook: @AddictionMedJC Facebook Group: Addiction Medicine Journal Club Instagram: @AddictionMedJC Threads: @AddictionMedJC YouTube: addictionmedicinejournalclub Twitter/X: @AddictionMedJC --- Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. Learn more about your ad choices. Visit megaphone.fm/adchoices
In this episode we review 4 more practice changing articles with real-life case studies. Söderpalm B, Et al. Efficacy and safety of varenicline and bupropion, in combination and alone, for alcohol use disorder: a randomized, double-blind, placebo-controlled multicentre trial. Lancet Reg Health Eur. 2025 May 13;54:101310. Hendershot CS, Et al. Once-Weekly Semaglutide in Adults With Alcohol Use Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2025 Feb 12:e244789. Rigotti NA, et al. Cytisinicline for Smoking Cessation: The ORCA Phase 3 Replication Randomized Clinical Trial. JAMA Intern Med. 2025 Jun 1;185(6):648-655. Parks MJ, et al. Cigarette Smoking During Recovery From Substance Use Disorders. JAMA Psychiatry. Published online August 13, 2025. Thank you to the Pennsylvania Society of Addiction Medicine! --- This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ --- Original theme music: composed and performed by Benjamin Kennedy Audio editing: Michael Bonanno Executive producer: Dr. Patrick Beeman A podcast from Ars Longa Media --- This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice. The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. --- Email: addictionmedicinejournalclub@gmail.com Facebook: @AddictionMedJC Facebook Group: Addiction Medicine Journal Club Instagram: @AddictionMedJC Threads: @AddictionMedJC YouTube: addictionmedicinejournalclub Twitter/X: @AddictionMedJC --- Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. Learn more about your ad choices. Visit megaphone.fm/adchoices
In this episode we review 4 practice changing articles with real-life case studies. Coughlin LN, Et al. Contingency Management for Stimulant Use Disorder and Association With Mortality: A Cohort Study. Am J Psychiatry. 2025 Nov 1;182(11):1016-1023. Shiwach R, Et al. Rapid vs Standard Induction to Injectable Extended-Release Buprenorphine: A Randomized Clinical Trial. JAMA Netw Open. 2025;8(10):e2537319. Nosyk B, Et al. Buprenorphine/Naloxone vs Methadone for the Treatment of Opioid Use Disorder. JAMA. 2024 Oct 17. McHugh RK, et al. Behavioral Therapy as an Adjunct to Buprenorphine Treatment for Opioid Use Disorder: A Secondary Analysis of 4 Randomized Clinical Trials. JAMA Netw Open. 2025 Aug 1;8(8):e2528529. Thank you to the Pennsylvania Society of Addiction Medicine! --- This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ --- Original theme music: composed and performed by Benjamin Kennedy Audio editing: Michael Bonanno Executive producer: Dr. Patrick Beeman A podcast from Ars Longa Media --- This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice. The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. --- Email: addictionmedicinejournalclub@gmail.com Facebook: @AddictionMedJC Facebook Group: Addiction Medicine Journal Club Instagram: @AddictionMedJC Threads: @AddictionMedJC YouTube: addictionmedicinejournalclub Twitter/X: @AddictionMedJC --- Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. Learn more about your ad choices. Visit megaphone.fm/adchoices
In episode 73 we discuss the risk of long-term opioid use after an initial opioid prescription. Smith AM, Shah A, Martin BC. An updated view on the influence of initial opioid prescription characteristics on long-term opioid use among opioid naïve patients. Drug Alcohol Depend. 2024 Dec 1;265:112463. We also discuss alcohol’s place in the new dietary guidelines, and Canada’s drug decriminalization project. The White House: Press briefing on the new dietary guidelines (Dr. Oz’s remarks start at 30:54) FDA: Dietary Guidelines (old and new) CityNews: B.C. to end drug decriminalization project, after ‘challenging’ three-year-experiment --- This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ --- Original theme music: composed and performed by Benjamin Kennedy Audio editing: Michael Bonanno Executive producer: Dr. Patrick Beeman A podcast from Ars Longa Media --- This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice. The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. --- Email: addictionmedicinejournalclub@gmail.com Facebook: @AddictionMedJC Facebook Group: Addiction Medicine Journal Club Instagram: @AddictionMedJC Threads: @AddictionMedJC YouTube: addictionmedicinejournalclub Twitter/X: @AddictionMedJC --- Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. Learn more about your ad choices. Visit megaphone.fm/adchoices
In episode 72 we discuss a telemedicine protocol for outpatient symptom-triggered alcohol withdrawal management. Sloan ME, Ngoy A, Xiao KB, Barker B, Buckley L, Fodor M, Hardy K, Hendershot CS, Kahan M, La Fleur S, Le Foll B, Manicone M, Sanches M, Simpkin E, Quilty LC, Wyman J, Tang VM, Bozinoff N. Symptom-Triggered Alcohol Withdrawal Management Delivered Over Telemedicine. J Addict Med. 2025 Nov-Dec 01;19(6):708-715. We also discuss Trump Administration actions that facilitate addiction, including the cancellation of SAMHSA grants, loosening restrictions and regulations on alcohol, cannabis and psychedelics, and the pardoning of drug kingpins. ASAM: ASAM Statement on Marijuana Rescheduling Executive Order Complex: Here's The Drug Dealers Donald Trump Has Pardoned NPR: Trump administration sends letter wiping out addiction, mental health grants NPR: Trump administration rolls back $2 billion mental health, addiction grant cuts --- This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ --- Original theme music: composed and performed by Benjamin Kennedy Audio editing: Michael Bonanno Executive producer: Dr. Patrick Beeman A podcast from Ars Longa Media --- This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice. The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. --- Email: addictionmedicinejournalclub@gmail.com Facebook: @AddictionMedJC Facebook Group: Addiction Medicine Journal Club Instagram: @AddictionMedJC Threads: @AddictionMedJC YouTube: addictionmedicinejournalclub Twitter/X: @AddictionMedJC --- Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. Learn more about your ad choices. Visit megaphone.fm/adchoices
In episode 71 we discuss dental problems caused by buprenorphine. Tuan WJ, Clebak KT, Jawadi E, Snyder J, Zgierska AE. Risk of Oral Health Problems in Adults With Opioid Use Disorder Treated With Transmucosal Buprenorphine. J Addict Med. 2025 Sep-Oct 01;19(5):529-535. We also discuss over-the-counter naltrexone and what RFK said at his senate confirmation hearing about substance use disorder. JAMA Psychiatry: Over-the-Counter Naltrexone to Address Unhealthy Alcohol Use NPR: RFK Jr. says he'll fix the overdose crisis. Critics say his plan is risky --- This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ --- Original theme music: composed and performed by Benjamin Kennedy Audio editing: Michael Bonanno Executive producer: Dr. Patrick Beeman A podcast from Ars Longa Media --- This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice. The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. --- Email: addictionmedicinejournalclub@gmail.com Facebook: @AddictionMedJC Facebook Group: Addiction Medicine Journal Club Instagram: @AddictionMedJC Threads: @AddictionMedJC YouTube: addictionmedicinejournalclub Twitter/X: @AddictionMedJC --- Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. Learn more about your ad choices. Visit megaphone.fm/adchoices
Quick summaries of our last 10 articles, perfect for busy people! 61. Safety of Buprenorphine/Naloxone vs. Buprenorphine in Pregnancy Straub L, et al. Comparative Safety of In Utero Exposure to Buprenorphine Combined With Naloxone vs Buprenorphine Alone. JAMA. 2024 Sep 10;332(10):805-816. 62. Naltrexone Pills vs Injections for Alcohol Use Disorder Magane KM, et al. Oral vs Extended-Release Injectable Naltrexone for Hospitalized Patients With Alcohol Use Disorder: A Randomized Clinical Trial. JAMA Intern Med. 2025 Jun 1;185(6):635-645. 63. Buprenorphine Dose and Neonatal Opioid Withdrawal Marc B, et al. Is buprenorphine maternal dose associated with neonatal opioid withdrawal syndrome severity? Am J Addict. 2025 Jan;34(1):15-20. 64. Screen Addiction and Suicide Xiao Y, et al. Addictive Screen Use Trajectories and Suicidal Behaviors, Suicidal Ideation, and Mental Health in US Youths. JAMA. 2025;334(3):219–228. 65. Varenicline and Bupropion for Alcohol Use Disorder Söderpalm B, et al. Efficacy and safety of varenicline and bupropion, in combination and alone, for alcohol use disorder: a randomized, double-blind, placebo-controlled multicentre trial. Lancet Reg Health Eur. 2025 May 13;54:101310. 66. Smoking in Recovery Parks MJ, , et al. Cigarette Smoking During Recovery From Substance Use Disorders. JAMA Psychiatry. Published online August 13, 2025. 67. Rapid-Start Injectable Buprenorphine Waters RC, et al. Injectable-Only Overlapping Buprenorphine Starting Protocol in a Low-Threshold Setting. JAMA Netw Open. 2025;8(8):e2527016. 68. Behavioral Treatments as an Adjunct to Buprenorphine McHugh RK, et al. Behavioral Therapy as an Adjunct to Buprenorphine Treatment for Opioid Use Disorder: A Secondary Analysis of 4 Randomized Clinical Trials. JAMA Netw Open. 2025 Aug 1;8(8):e2528529. 69. Cytisinicline for Smoking Cessation Rigotti NA, et al. Cytisinicline for Smoking Cessation: The ORCA Phase 3 Replication Randomized Clinical Trial. JAMA Intern Med. 2025 Jun 1;185(6):648-655. 70. Prescription Stimulant Misuse Han B, Jones CM, Volkow ND, et al. Prescription Stimulant Use, Misuse, and Use Disorder Among US Adults Aged 18 to 64 Years. JAMA Psychiatry. 2025;82(6):572–581. --- No CME for this episode, but other episodes offer category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To learn more about opportunities in addiction medicine, visit MI CARES. CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ --- Original theme music: composed and performed by Benjamin Kennedy Audio editing: Michael Bonanno Executive producer: Dr. Patrick Beeman A podcast from Ars Longa Media --- This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice. The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. --- Email: addictionmedicinejournalclub@gmail.com Facebook: @AddictionMedJC Facebook Group: Addiction Medicine Journal Club Instagram: @AddictionMedJC Threads: @AddictionMedJC YouTube: addictionmedicinejournalclub Twitter/X: @AddictionMedJC --- Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. Learn more about your ad choices. Visit megaphone.fm/adchoices
In episode 70 we discuss an article about prescription stimulant misuse. Han B, Jones CM, Volkow ND, et al.Prescription Stimulant Use, Misuse, and Use Disorder Among US Adults Aged 18 to 64 Years. JAMA Psychiatry. 2025;82(6):572–581. We also discuss the ASAM toolkit for addressing problems at the pharmacy with buprenorphine, and results of the 2024 NSDUH study. ASAM:Addressing Issues at the Pharmacy with Buprenorphine Prescriptions Link to report pharmacy issues STATNews:Tobacco use, binge drinking decrease as Americans consume more marijuana, survey finds --- This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go tothis link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visitMI CARES. CME:https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ --- Original theme music:composed and performed by Benjamin Kennedy Audio editing: Michael Bonanno Executive producer:Dr. Patrick Beeman A podcast fromArs Longa Media --- This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice. The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. --- Email: addictionmedicinejournalclub@gmail.com Facebook:@AddictionMedJC Facebook Group:Addiction Medicine Journal Club Instagram:@AddictionMedJC Threads:@AddictionMedJC YouTube:addictionmedicinejournalclub Twitter/X:@AddictionMedJC --- Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. Learn more about your ad choices. Visit megaphone.fm/adchoices
In episode 69 we discuss cytisinicline for smoking cessation. Rigotti NA, et al. Cytisinicline for Smoking Cessation: The ORCA Phase 3 Replication Randomized Clinical Trial. JAMA Intern Med. 2025 Jun 1;185(6):648-655. We also discuss treating opioid use disorder in nursing homes and compulsive TikTok scrolling. Carolina Public Press: NC nursing home lawsuit settlement could expand access for people with drug issues MedicalXpress: Adults 65 years and older not immune to the opioid epidemic, study finds Washington Post: How TikTok keeps its users scrolling for hours a day Note: Sonya mispronounces "cytisinicline" throughout this episode. Our apologies! --- This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ --- Original theme music: composed and performed by Benjamin Kennedy Audio editing: Michael Bonanno Executive producer: Dr. Patrick Beeman A podcast from Ars Longa Media --- This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice. The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. --- Email: addictionmedicinejournalclub@gmail.com Facebook: @AddictionMedJC Facebook Group: Addiction Medicine Journal Club Instagram: @AddictionMedJC Threads: @AddictionMedJC YouTube: addictionmedicinejournalclub Twitter/X: @AddictionMedJC --- Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. Learn more about your ad choices. Visit megaphone.fm/adchoices
In episode 68 we discuss an article about adding behavioral treatments to buprenorphine for opioid use disorder. McHugh RK, et al. Behavioral Therapy as an Adjunct to Buprenorphine Treatment for Opioid Use Disorder: A Secondary Analysis of 4 Randomized Clinical Trials. JAMA Netw Open. 2025 Aug 1;8(8):e2528529. We also discuss online gambling addiction, and neuroanatomy that predisposes adolescents to addiction. Stat News: Head of addiction medicine society warns of treatment cuts and rising threat of gambling Miller AP, et al. Neuroanatomical Variability and Substance Use Initiation in Late Childhood and Early Adolescence. JAMA Netw Open. 2024;7(12):e2452027. --- This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ --- Original theme music: composed and performed by Benjamin Kennedy Audio editing: Michael Bonanno Executive producer: Dr. Patrick Beeman A podcast from Ars Longa Media --- This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice. The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. --- Email: addictionmedicinejournalclub@gmail.com Facebook: @AddictionMedJC Facebook Group: Addiction Medicine Journal Club Instagram: @AddictionMedJC Threads: @AddictionMedJC YouTube: addictionmedicinejournalclub Twitter/X: @AddictionMedJC --- Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. Learn more about your ad choices. Visit megaphone.fm/adchoices
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