Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

The course of history is affected by many things, including the political and social situations of large groups of people, their biological and physical abilities, and their geographical and environmental contexts. Sometimes, it would seem, history -- or corporations, or religions, or sports teams -- can be affected by the actions of just a few influential persons. In his new book, Profits, Prophets, Coaches, and Kings , Jared Diamond asks what effect leaders can have, and what it is that makes them successful (or not). Right now, Babbel is offering listeners who want to learn a new language up to 60% off. Go to https://babbel.com/MINDSCAPE . #ad Preserve your online privacy at Incogni and get 60% off an annual plan at https://incogni.com/MINDSCAPE . #ad Monthly pledges to FarmKind to help fight factory farming will be boosted by 50% at https://farmkind.giving/MINDSCAPE . #ad Blog post with transcript: https://preposterousuniverse.com/podcast/2026/09/07/367-jared-diamond-on-the-course-of-history-and-the-role-of-leaders/ Support Mindscape on Patreon . Jared Diamond received a Ph.D. in physiology from the University of Cambridge. He is currently a professor of geography at the University of California, Los Angeles. Among his awards are the U.S. National Medal of Science, the MacArthur Fellowship, and the Pulitzer Prize. His international bestseller Guns, Germs, and Steel has sold over seven million copies. Web site UCLA web page Amazon author page Wikipedia

Everyone lives through time, but we continue to struggle to fully understand it. We remain unsure whether time is fundamental or emergent, why it has an arrow pointing from past to future, and how that arrow connects to our experience of time's passage. Jim Al-Khalili's new book is On Time: The Physics that Makes the Universe Tick . We discuss what time is at the most basic level, and how it connects to open questions in biology, cosmology, and quantum mechanics. Mindscape listeners can try StatsKey Pro free for one month with code MINDSCAPE . After that, it's $4.99 per month unless canceled. #ad Blog post with transcript: https://preposterousuniverse.com/podcast/2026/08/31/366-jim-al-khalili-on-time-quantum-biology-and-cosmology/ Support Mindscape on Patreon . Jim Al-Khalili received his Ph.D. in physics from the University of Surrey. He is currently Distinguished Emeritus Professor of Physics at Surrey. He is a Fellow of the Royal Society, and has served as past president of the British Science Association. He has been awarded the Michael Faraday Prize by the Royal Society, and has been appointed an appointed Officer of the Order of the British Empire. Web site University of Surrey web page Google Scholar publications Amazon author page Wikipedia YouTube

Black holes, as Stephen Hawking discovered, do grow old: they emit radiation, lose mass, and eventually evaporate away. But our fascination with black holes never grows old. This is especially true today, as we are seeing a flood of new data and intriguing theoretical ideas, which both tests the limits of Einstein's general relativity and teach us new things about the astrophysical universe. At the Center of Gravity at the University of Copenhagen, they are currently celebrating Black Hole Week , which provides an excellent opportunity to talk with Center director Vitor Cardoso about what we've been learning about these singular cosmic objects. Use code MINDSCAPE at https://monarch.com/ to get your first year of Monarch Core half off at just $50. #ad Upgrade your everyday and get free shipping and 365-day returns at https://quince.com/MINDSCAPE . #ad See what ElevenAgents can do for your specific workflows at https://elevenlabs.io/MINDSCAPE . #ad Blog post with transcript: https://preposterousuniverse.com/podcast/2026/08/24/365-vitor-cardoso-on-why-black-holes-are-special/ Support Mindscape on Patreon . Vitor Cardoso received his Ph.D. in physics from the Instituto Superior Técnico in Portugal. He is currently a Villum Investigator and Director of the Center of Gravity at the Niels Bohr Institute in Copenhagen, and a Distinguished Professor at Técnico. Web site University of Copenhagen web page Simons Collaboration page Google Scholar publications

One of the paradoxes of science is that it seeks objectively true understanding of the world, but its methodology is driven by ignorance, failure, and uncertainty. Some phenomena we understand pretty well, but interesting research happens at the boundary of what we do and don't know. And there is no foolproof algorithm for moving in the right direction; we need to make conjectures and test them against the world. Biologist Stuart Firestein has been advocating for a better public understanding of the true methods of science, most recently in his new book It Could Be Otherwise: Science In the Age of Uncertainty . Stop piecing your software together. Go to Odoo.com/mindscape to learn more. #ad Mindscape listeners can try StatsKey Pro free for one month with code MINDSCAPE . After that, it's $4.99 per month unless canceled. #ad Blog post with transcript: https://preposterousuniverse.com/podcast/2026/08/17/364-stuart-firestein-on-how-science-relies-on-ignorance-and-failure/ Support Mindscape on Patreon (opens in new tab) . Stuart Firestein received his Ph.D. in neurobiology from the University of California, Berkeley. He is currently Professor of Neuroscience at in the Department of Biological Sciences at Columbia University, and Fractal Faculty at the Santa Fe Institute. He is a fellow of the American Association for the Advancement of Science, the Sloan Foundation, and the Guggenheim Foundation. His research studies cellular mechanisms of signal transduction and olfaction. His previous books include Ignorance: How It Drives Science and Failure: Why Science Is So Successful . Columbia web page Google Scholar publications Amazon author page Wikipedia

Large Language Models display an uncanny ability to construct human-sounding speech, and can synthesize concepts in novel ways. Is this because they are truly thinking like human beings in some way, or have they found a way to be human-like without reproducing the internal mechanisms of human thought? Chandra Sripada argues that LLM cognition is more human-like than we suppose, and offers evidence from the ways that cognitive scientists study actual humans. Blog post with transcript: https://preposterousuniverse.com/podcast/2026/08/10/363-chandra-sripada-on-how-llms-and-humans-are-cognitive-cousins/ Support Mindscape on Patreon . Chandra Sripada received an M.D. from the University of Texas and a Ph.D. in philosophy from Rutgers University. He is currently a professor of philosophy and psychiatry at the University of Michigan, where he holds the Theophile Raphael Research Professorship and directs the Weinberg Institute for Cognitive Science. He writes Cognition, Decoded , a Substack newsletter about AI, cognitive science, and philosophy. Web site Google Scholar publications PhilPeople profile Babbel is offering listeners up to 60% off. Go to https://babbel.com/MINDSCAPE . #ad Get 60% off an annual plan from Incogni using code MINDSCAPE at https://incogni.com/mindscape . #ad

Welcome to the August 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy! Blog post with questions and full transcript: https://preposterousuniverse.com/podcast/2026/08/03/ama-august-2026/ Support Mindscape on Patreon .

People who live in large cities produce more patents per person than those who live in small towns. They also walk faster down the street, and use less infrastructure per person. Indeed, the relationships between these quantities and city population obey power laws with apparently universal exponents, reminiscent of scaling laws is biological organisms? Luis Bettencourt argues that they can be explained in similar ways, using ideas from complex systems and network theory. Blog post with transcript: https://preposterousuniverse.com/podcast/2026/07/27/362-luis-bettencourt-on-the-universal-properties-of-self-organizing-cities/ Support Mindscape on Patreon . Luis Bettencourt received a Ph.D. in theoretical physics from Imperial College London. He is currently the Lorna Puttkammer Straus Professor Department of Ecology and Evolution & Data Sciences Institute, as well as Associate Faculty and Special Friend in the Department of Sociology, at the University of Chicago. He is the author of Introduction to Urban Science: Evidence and Theory of Cities as Complex Systems . Web site University of Chicago web page Google Scholar publications Wikipedia

One of the characteristics of life is that living organisms gather information and put it to use. Even one of the simplest lifeforms, bacteria, are able to sense features of their surroundings and alter their behavior accordingly. Most impressively, they are able to sense the presence of similar bacteria by a process called quorum sensing . Today's guest, Bonnie Bassler, is a leader in this field, and explains how quorum sensing allows groups of bacteria to do things (including in our bodies) that wouldn't be possible for individual bacteria. Blog post with transcript: https://preposterousuniverse.com/podcast/2026/07/20/361-bonnie-bassler-on-how-bacteria-talk-and-work-together/ Support Mindscape on Patreon . Bonnie Bassler received a Ph.D. in biochemistry from Johns Hopkins University. She is currently Andrew K. Golden University Professor of Molecular Biology at Princeton University and a Howard Hughes Medical Institute Investigator. She is a member of the National Academy of Sciences, National Academy of Medicine, and the American Academy of Arts and Sciences. Among her awards are a MacArthur Fellowship, the Gruber Prize in Genetics, and the National Medal of Science. Lab web site Princeton web page Google Scholar publications Wikipedia

Welcome to the July 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy! Blog post with transcript: https://preposterousuniverse.com/podcast/2026/07/13/ama-july-2026/ Support Mindscape on Patreon .

Modern life has, in many ways, removed us from the environments in which our ancestors lived and adapted. Not only do we spend time looking at screens, but we spend time indoors, or outdoors but in urban spaces. How does this affect how we think and feel? Psychologist Marc Berman is a pioneer of "environmental neuroscience." In his recent book, Nature and the Mind: The Science of How Nature Improves Cognitive, Physical, and Social Well-Being , he presents evidence that spending time in nature not only puts us in a better mood, it makes us better thinkers. Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/07/06/360-marc-berman-on-the-science-of-touching-grass/ Support Mindscape on Patreon . Marc Berman received his Ph.D. in psychology from the University of Michigan. He is currently Professor of Psychology and Faculty Co-Director of the Chicago Center for Computational Social Science at the University of Chicago. Among his awards is the American Psychological Association Distinguished Scientific Award for Early Career Contributions. Environmental Neuroscience Lab U. Chicago web page Google Scholar publications Amazon author page

The cosmological constant, as discussed last episode, provides a perfectly good (thus far) explanation for why we observe the universe to be accelerating. But it might not be the right explanation, and demonstrating that would be yet another foundational discovery. In this episode I discuss what is required to invent a plausible theory of dynamical dark energy , This includes considerations from particle physics, possible experimental tests, and the option that we should modify gravity rather than adding a new source of energy to the equations. Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/06/29/359-solo-theories-of-dark-energy/ Support Mindscape on Patreon .

The most surprising discovery in fundamental physics during my career as a scientist was undoubtedly the acceleration of the universe , announced in 1998. The most straightforward explanation for these observations is a positive cosmological constant, or vacuum energy. I talk about the origin of the idea with Einstein, how quantum physicists started to think about it and understand the "cosmological constant problem," as well as how its discovery also raised the "coincidence problem." This is the first of two connected solo episodes; the next will be on theories of dark energy that are not the cosmological constant. Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/06/22/358-solo-vacuum-energy-and-the-cosmological-constant/ Support Mindscape on Patreon .

Messenger RNA (mRNA) plays a literally central role in the functioning of life as we know it, shuttling information back and forth between the DNA where it is stored to the ribosome where it is used to produce proteins. RNA may even have been the first molecule to kick-start the origin of life. Today, scientists are learning how to manipulate mRNA to cure and prevent diseases, whether through vaccination or literally editing one's DNA. Jeff Coller explains how it all works and how mRNA is revolutionizing medicine as we know it. Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/06/15/357-jeff-coller-on-mrna-vaccines-and-bespoke-therapeutics/ Support Mindscape on Patreon . Jeff Coller received his Ph.D. in cell and molecular biology from the University of Wisconsin-Madison. He is currently Bloomberg Distinguished Professor of Biomedical Engineering and Director of the RNA Innovation Center at Johns Hopkins University. He is co-founder of Tevard Biosciences and the Alliance for mRNA Medicines, and leads the REPAIRx consortium. He is a fellow of the American Association for the Advancement of Science. Web site Johns Hopkins web page Google Scholar publications "This May Be the Most Important Medical Story of the Decade," New York Times, April 9, 2026

All ideas have a history, no matter how inevitable and well-entrenched they may seem to us today. The later Enlightenment was a heady time when people were exploring new conceptions of nature, humanity, and the self. Andrea Wulf is a writer of narrative histories, examining the origins of ideas through the lives of the people who explored them. In this episode we discuss three of her books: The Invention of Nature , about Alexander von Humboldt and environmentalism; Magnificent Rebels , about the Jena circle of Romantics including Goethe, Schiller, Schlegel, and others; and most recently The Traveller , about George Forster, an early naturalist, ethnographer, and champion of human equality. Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/06/08/356-andrea-wulf-on-enlightenment-nature-romanticism-and-modernity/ Support Mindscape on Patreon . Andrea Wulf was born in India, raised in Germany, and studied design history at the Royal College of Art, London. She is the author of seven books. She is a Miller Scholar at the Santa Fe Institute and a Fellow of the Royal Society of Literature. The Invention of Nature won multiple prizes, including the Royal Society science book prize and the LA Times book prize. Web site Amazon author page Wikipedia

Welcome to the June 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy! Blog post with AMA questions and transcript: https://www.preposterousuniverse.com/podcast/2026/06/01/ama-june-2026/ New paper I talk about in the beginning of the episode: S.M. Carroll, N. Diachenko, and S. Dulani, "Toward a Phenomenologically Acceptable Quantum Cyclic Universe."

One of the major obstacles to understanding quantum mechanics is the difficulty we have in simply accepting what the theory itself is telling us. The problem is that we know what the everyday world looks like -- stuff, arranged in space, evolving through time. So we can't resist the temptation to impose that picture on the quantum description, even if it's not actually there. In this solo episode I talk about what it means to take quantum mechanics at face value, and the difficult work involved in understanding how the everyday world of our experience fits into the picture. Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/05/25/355-solo-looking-quantum-mechanics-in-the-eyeball/ Support Mindscape on Patreon . Here is the survey on physicists' opinions about unsettled big-picture questions: Afshordi, Halper, Rini, and Schirber, " Big Mysteries Survey: Physicists' Views on Cosmology , Black Holes, Quantum Mechanics, and Quantum Gravity ." And here is a short technical overview on the ideas described in this episode: Carroll, " Reality as a Vector in Hilbert Space. " If you want further papers, look at the papers cited in this one.

Did I have any freedom in choosing this particular podcast guest? At the level of particles, fields, and the fundamental laws of physics; no. At the level of human agents navigating the world, yes. Today's guest, Christian List, is a philosopher and political scientist who has arguably done the most to articulate the "compatibilist" perspective on free will, according to which the freedom of rational agents is entirely compatible with underlying mechanistic laws. The reconciliation depends on thinking carefully about emergence and the relationship between levels of reality. Take your personal data back with Incogni! Use code MINDSCAPE at this link and get 60% off an annual plan: https://incogni.com/ mindscape #sponsored Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/05/18/354-christian-list-on-free-will-and-levels-of-reality/ Support Mindscape on Patreon . Christian List received his D.Phil in Politics from Oxford University. He is currently Professor of Philosophy and Decision Theory and Co-Director of the Munich Center for Mathematical Philosophy at LMU Munich. He is a Fellow of the British Academy and a member of Academia Europaea the Bavarian Academy of Sciences and Humanities. Among his honors are the Joseph Gittler Award from the American Philosophical Association. He is the author of Why Free Will Is Real and (with Philip Pettit) Group Agency . Web site LMU web page Google Scholar publications Amazon author page Wikipedia

Economic markets are efficient ways of deciding fair prices, at least in ideal circumstances of perfect competition, information, and choice. But there is more to life than fair prices. Two people might decide on a fair price to carry out a contract killing, but society generally frowns on the idea. Many examples of morally contestable markets feature less consensus than that one: sex work, drugs, selling organs, adopting children. In his new book Moral Economics , economist Alvin Roth investigates how we should reason through such tricky cases, and what we can learn from them. Get twenty percent off your first purchase at Fast Growing Trees when using the code MINDSCAPE at checkout. Mindscape listeners get free shipping and 365-day returns on clothing from Quince . Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/05/11/353-alvin-roth-on-the-economics-of-morally-contested-markets/ Support Mindscape on Patreon . Alvin Roth received his Ph.D. in operations research from Stanford University. He is currently the Craig and Susan McCaw Professor of Economics at Stanford University and the Gund Professor of Economics and Business Administration Emeritus at Harvard. He was President of the American Economic Association in 2017. He and Lloyd Shapley shared the 2012 Nobel Prize in Economics for "the theory of stable allocations and the practice of market design." Stanford web page Google Scholar publications Amazon author page Wikipedia

Welcome to the May 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy! Blog post with AMA questions and full transcript: https://www.preposterousuniverse.com/podcast/2026/05/04/ama-may-2026/ Henson Shaving is offering 100 blades free with the purchase of a razor — just head to hensonshaving.com/MINDSCAPE and or use code MINDSCAPE at checkout. #sponsored Take your personal data back with Incogni! Use code MINDSCAPE at this link and get 60% off an annual plan: https://incogni.com/ mindscape #sponsored

The connectome is the wiring diagram of a brain, a big matrix that tells us what neurons talk to what other neurons. Understanding it is an important step to understanding how brains work, but a long way from the final answer. A big next step is understanding how neuronal circuits connect to and guide bodily behavior. Very recent work on mapping the fruit-fly connectome has brought us closer to that goal. I talk with neuroscientist Bing Brunton about the connectome, how we can study it to understand bodily motion in flies and other creatures, and where it's all taking us. Chubbies is here to keep you comfy and looking good year-round. Get 20% off with code MINDSCAPE at chubbiesshorts.com/MINDSCAPE ! #chubbiespod Upgrade your denim game with Rag & Bone! Get 20% off sitewide with code MINDSCAPE at www.rag-bone.com . #ragandbonepod Support Mindscape on Patreon . Blog post with transcript: https://www.preposterousuniverse.com/podcast/2026/04/27/352-bing-brunton-on-connecting-the-connectome-to-the-body/ Bing Wen Brunton received her Ph.D. in neuroscience from Princeton University.. She is currently a Professor of Biology and the Richard & Joan Komen University Chair at the University of Washington, with affiliations at the eScience Institute for Data Science, the Paul G. Allen School of Computer Science & Engineering, and the Department of Applied Mathematics. Web site University of Washington web page Google Scholar publications YouTube channel Bluesky Artworks (Instagram)